Date: 31.01.2018

PhD student opening in Molecular Parasitology

Evolutionary Cell Biology of Mitochondrial Cristae Biogenesis

Evolutionary Cell Biology of Mitochondrial Cristae Biogenesis

Czech Academy of Sciences & University of South Bohemia

Ceske Budejovice, Czechia

The Project:

Our team is engaged in the biogenesis of mitochondrial cristae, the folds within the organelle that give it its characteristic appearance, by evolutionary cell biology. This multidisciplinary approach utilizes reverse genetics, biochemistry, bioinformatics plus molecular and cell biology techniques. We are focused on the MICOS complex, a set of proteins needed for proper cristae morphology. While well-studied in classical models such as yeast and human cells, they represent only one clade in terms of eukaryotic diversity. To gain more insight into core functions and potential novelties of MICOS, we exploit an established model system in the highly diverged and fascinating Excavata clade called Trypanosoma brucei. As a result of being intensely researched due to its status as a human and veterinarian parasite, T. brucei has a well-developed genetic toolkit. Furthermore, its life cycle which involves profound reshaping of the mitochondrion makes it an excellent model for studying cristae biogenesis. This work is supported by funding from the Czech Science Foundation, allowing augmentation of a student stipend for a comfortable life in a low cost country.

The lab:

The MICOS team is a working group led by doc. Hassan Hashimi within the internationally-recognized Laboratory of Molecular Biology of Protists headed by Prof. Julius Lukeš. Furthermore, we cooperate closely with two other laboratories studying trypanosomes, thus creating a stimulating and fun environment for scientific pursuit. The laboratories are an international collective, with students and post-doctoral fellows from all over the world.

The laboratory is based at the Institute of Parasitology at the Biology Centre, Czech Academy of Sciences, which is dedicated to performing research on human and animal parasites at the organismal, cellular and molecular levels. It is located on a campus shared with the University of South Bohemia in the historic town České Budějovice, which offers many cultural and recreational activities in addition to its close proximity to the Czech capital Prague (2hrs), wonderful local scenery and the Austrian Alps.

More info at: http://www.paru.cas.cz/en/sections/molecular-parasitology/laboratory-of-molecular-biology-of-protists/

How to apply:

Good English, independent thinking, strong interest in basic research and experimental work are required. Interested candidates with M.Sc. degree (or equivalent) in biochemistry or molecular/cellular biology should apply by submitting the following documents:

• Curriculum Vitae (CV)

• List of 1-2 referees that can testify about the professional qualities of the candidate

• Letter of intent that explains the reasons for your interest in our laboratory and identifies your most relevant skills or experiences.

Contact and Deadline:

doc. Hassan Hashimi

hassan@paru.cas.cz

DEADLINE: 31 January 2018

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CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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