Mgr. Pavel Flegontov, Ph.D.

Job Position: Research Scientist - Laboratory of Molecular Biology of Protists , Research Scientist - Laboratory of Molecular Biology of Protists

Contact details

Phone: +420 387775439
E-mail: pavel@paru.cas.cz

Description

Mitoproteome of Trypanosoma brucei is now catalogued. But a lot of mitochondrial proteins have completely unknown or poorly defined functions. Some of those obscure proteins appear to be conserved in eukaryotes. We focus on a group of about a dozen conserved proteins, and by making RNAi knockdowns in T. brucei try to get an idea of their functions.

Publications
Total found: 21 records
Ishemgulova A., Butenko A., Kortišová L., Boucinha C., Grybchuk-Ieremenko A., Morelli K., Tesařová M., Kraeva N., Grybchuk D., Pánek T., Flegontov P., Lukeš J., Votýpka J., Pavan M.G., Opperdoes F., Spodareva V., D'avila-Levy C., Kostygov A., Yurchenko V. (2017) Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila PLoS ONE 12 : e0174165.
DOI: 10.1371/journal.pone.0174165

Documents to download:
Ishemgulova et al. 2017 PLoS ONE (pdf)
Tanifuji G., Cenci U., Moog D., Dean S., Nakayama T., David V., Fiala I., Curtis B., Sibbald S.J., Onodera N., Colp M., Flegontov P., Johnson-MacKinnon J., McPhee M., Inagaki Y., Hashimoto T., Kelly S., Gull K., Lukeš J., Archibald J. (2017) Genome sequencing reveals metabolic and cellular interdependence in an amoebakinetoplastid symbiosis Scientific Reports 7 : 11688.
DOI: 10.1038/s41598-017-11866-x

Documents to download:
Tanifuji et al. 2017 SR (pdf)
Flegontov P., Butenko A., Firsov S., Kraeva N., Eliáš M., Field M., Filatov D., Flegontova O., Gerasimov E., Hlaváčová J., Jackson A., Ishemgulova A., Kelly S., Kostygov A., Logacheva M., Maslov D., Opperdoes F., O’Reilly A., Sádlová J., Ševčíková T., Venkatesh D., Vlček Č., Volf P., Votýpka J., Záhonová K., Yurchenko V., Lukeš J. (2016) Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania Scientific Reports 6 : 23704.
DOI: 10.1038/srep23704

Documents to download:
Flegontov et al. 2016 SR6:23704 (pdf)
Flegontov P., Changmai P., Zidkova A., Logacheva M., Logacheva M., Flegontova O., Nikolsky Y., Starostin G., Stepanova V., Travinsky I., Tříska M., Tříska P., Tatarinova T. (2016) Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry Scientific Reports 6 : 20768.
DOI: 10.1038/srep20768

Documents to download:
Flegontov et al. 2016 Scientific Reports (pdf)
Flegontov P., Kassian A., Thomas M., Fedchenko V., Changmai P., Starostin G. (2016) Pitfalls of the Geographic Population Structure (GPS) Approach Applied to Human Genetic History: A Case Study of Ashkenazi Jews Genome Biology and Evolution 8 : 2259-2265.
DOI: 10.1093/gbe/evw162

Documents to download:
Flegontov et al. 2016 GBE (pdf)
Flegontova O., Flegontov P., Malviya S., Audic S., Wincker P., de Vargas C., Bowler C., Lukeš J., Horák A. (2016) Extreme diversity of diplonemid eukaryotes in the ocean Current Biology 26 : 3060-3065.
DOI: 10.1016/j.cub.2016.09.031

Documents to download:
Flegontova et al. 2016 CB (pdf)
Opperdoes F., Butenko A., Flegontov P., Yurchenko V., Lukeš J. (2016) Comparative metabolism of free-living Bodo saltans and parasitic trypanosomatids Journal of eukaryotic microbiology 63 : 657-678.
DOI: 10.1111/jeu.12315

Documents to download:
Opperdoes et al. 2016 JEM (pdf)
David V., Flegontov P., Gerasimov E., Tanifuji G., Hashimi H., Logacheva M., Maruyama S., Onodera N., Gray M., Archibald J., Lukeš J. (2015) Gene loss and error-prone RNA editing in the mitochondrion of Perkinsela, an endosymbiotic kinetoplastid mBio 6 : e01498-15.
DOI: 10.1128/mBio.01498-15

Documents to download:
David et al 2015 mBio (pdf)
Dobáková E., Flegontov P., Skalický T., Lukeš J. (2015) Unexpectedly streamlined mitochondrial genome of the euglenozoan Genome Biology and Evolution 7 : 3358-3367.
DOI: 10.1093/gbe/evv229

Documents to download:
Dobakova et al. 2015 GBE (pdf)
Flegontov P., Michálek J., Janouškovec J., Lai H., Jirků M., Hajdušková E., Tomčala A., Otto T., Keeling P., Pain A., Oborník M., Lukeš J. (2015) Divergent Mitochondrial Respiratory Chains in Phototrophic Relatives of Apicomplexan Parasites. Molecular Biology and Evolution 32 : 1115-1131.
DOI: 10.1093/molbev/msv021

Documents to download:
Flegontov et al. 2015 MBE (pdf)
Kraeva N., Butenko A., Hlaváčová J., Kostygov A., Myšková J., Grybchuk D., Leštinová T., Votýpka J., Volf P., Opperdoes F., Flegontov P., Lukeš J., Yurchenko V. (2015) Leptomonas seymouri: Adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani PLoS Pathogens 11 : e1005127.
DOI: 10.1371/journal.ppat.1005127

Documents to download:
Kraeva_et_al_PLOSPathogens_2015 (pdf)
Woo Y., Ansari H., Otto T., Klinger C., Kolísko M., Michálek J., Saxena A., Shanmugam D., Tayyrov A., Veluchamy A., Ali S., Bernal A., Del C., Cihlář J., Flegontov P., Gornik S., Hajdušková E., Horák A., Janouškovec J., Katris N., Mast F., Miranda-Saavedra D., Mourier T., Naeem R., Nair M., Panigrahi A., Rawlings N., Regelado E., Ramaprasad A., Samad N., Tomčala A., Wilkes J., Neafsey D., Doerig C., Bowler C., Keeling P., Roos D., Dacks J., Templeton T., Waller R., Lukeš J., Oborník M., Pain A. (2015) "Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites " eLife 4 : e06974.
DOI: 10.7554/eLife.06974

Documents to download:
Woo_et_al_eLife_2015 (pdf)
Porcel B., Denoeud F., Opperdoes F., Noel B., Madoui M., Hammarton T., Field M., Da Silva C., Couloux A., Poulain J., Katinka M., Jabbari K., Aury J., Campbell D., Cintron R., Dickens N., Docampo R., Sturm N., Koumandou V., Fabre S., Flegontov P., Lukeš J., Michaeli S., Mottram J., Szoor B., Zilberstein D., Bringaud F., Wincker P., Dollet M. (2014) The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants PLOS Genetics 10 : e1004007.
DOI: 10.1371/journal.pgen.1004007

Documents to download:
Porcel-PG-2014 (pdf)
Flegontov P., Votýpka J., Skalický T., Logacheva M., Penin A., Tanifuji G., Onodera N., Kondrashov A., Archibald J., Volf P., Lukeš J. (2013) Paratrypanosoma – SUPPLEMENTARY FIGURES Current Biology
Flegontov P., Votýpka J., Skalický T., Logacheva M., Penin A., Tanifuji G., Onodera N., Kondrashov A., Volf P., Archibald J., Lukeš J. (2013) Paratrypanosoma is a novel early-branching trypanosomatid Current Biology 23 : 1787-1793.
DOI: 10.1016/j.cub.2013.07.045

Documents to download:
2013_Flegontov_CurrBiol (pdf)
Janouškovec J., Sobotka R., Lai D., Flegontov P., Koník P., Komenda J., Ali S., Prášil O., Pain A., Oborník M., Lukeš J., Keeling P. (2013) Split photosystem protein, linear-mapping topology and growth of structural complexity in the plastid genome of Chromera velia Molecular Biology and Evolution 30 : 2447-2462.
DOI: 10.1093/molbev/mst144

Documents to download:
Janouskovec-MBE-2013 (pdf)
Burki F., Flegontov P., Oborník M., Cihlář J., Pain A., Lukeš J., Keeling P. (2012) Re-evaluating the Green versus Red Signal in Eukaryotes with Secondary Plastid of Red Algal Origin Genome Biol. Evol. 6 : 626-635.
DOI: 10.1093/gbe/evs049

Documents to download:
2012_Burki_Genome Biol Evol_6 (pdf)
Flegontov P., Lukeš J. (2012) Mitochondrial Genomes of Photosynthetic Euglenids and Alveolates Advances in Botanical Research 63 : 127-153.


Documents to download:
2012_Flegontov_Adv_Bot_Res_127 (pdf)
Flegontova O., Lukeš J., Flegontov P. (2012) Lack of evidence for integration of Trypanosoma cruzi minicircle DNA in South American human genomes. International Journal for Parasitology 42 : 437–441.
DOI: 10.1016/j.ijpara.2012.04.001

Documents to download:
2012_Flegontova-IJP-437 (pdf)
Kořený L., Sobotka R., Kovářová J., Gnipová A., Flegontov P., Horváth A., Oborník M., Ayala F., Lukeš J. (2012) Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability. PNAS 109 : 3808-3813.
DOI: 10.1073/pnas.1201089109

Documents to download:
2012 Koreny PNAS 3808 (pdf)

More publications

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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