RNDr. Petr Kopáček, CSc.

Job Position: Head of Laboratory - Laboratory of Vector Immunology

Contact details

Phone: +420 387772207, +420 387775476
E-mail: kopajz@paru.cas.cz
Room: 336

Curriculum vitae

Born

14th April, 1958, České Budějovice, Czechoslovakia

Education

1982: RNDr. (equivalent to M.Sc.) - graduated in physical chemistry at Faculty of Sciences, Charles University, Prague
1988: Postgradual course of analytical chemistry at Faculty of Sciences, Komenius University, Bratislava, Slovakia
1993: CSc. (equivalent to PhD.) in Biochemistry at Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic

Former and current positions

1982 - 1983: Institute of Parasitology, Czechoslovak Academy of Sciences, České Budějovice; assistentship on human protozoan isoenzymes
1983 - 1985: Institute of Entomology, Czech. Acad. Sci., České Budějovice, research assistant on insect olfaction physiology
1985 - 1993: Laboratory of Analytical Chemistry, Biol. Center Czech. Acad. Sci., České Budějovice, research assistant on protein analysis, electrophoresis and related techniques
1993 - 1995: Laboratory of Analytical Chemistry; Institute of Entomology, Czech Acad. Sci., České Budějovice, research worker on proteins involved in immune system of insects
1995 - 1996: Galena (IVAX), Research Unit, České Budějovice, research specialist on drug binding proteins
1996- : Institute of Parasitology, Biology Centre, Acad. Sci. Czech Rep. and Faculty of Sciences, University of South Bohemia, České Budějovice, senior scientist on immune proteins in ticks

Scientific stays, fellowships and courses

October - November 1989: Stay at Technical University Munich, Germany by Prof. B. Radola, study of isoelectric focusing and two-dimensional electrophoresis
October 1991 - March 1992: Stay at University of Uppsala, Sweden, Institute of Physiological Botany by Prof. K. Söderhäll; study on crayfish plasma proteins
May 1994 - June 1995: Fellowship from Alexander von Humboldt Foundation, Institute of Zoologie, Free University Berlin by Prof. P. Götz and Prof. M. Schweiger, study on insect prophenoloxidase system
April 1997 - June 1997: Stay at University of Arizona, Tucson, Center of Insect Science by Prof. John H. Law, within the BRAVO! program, work on tick ferritins
June 2000 - Course - Biology of Disease Vectors, Colorado State University, Fort Collins, Co
July 2000 – August 2000: Summer laboratory at Woods Hole, Ma. Co-operation with Prof. Peter B. Armstrong (University of California), on alpha-2-macroglobulin receptor from Limulus
September 2002: HHMI/NRC sponsored course: "Genome-wide Approaches to Understanding Bacterial Pathogenesis”, Institute of Microbiology, Prague, Czech Rep.
October-November 2003: EMBO practical course: "Integrated Molecular Diagnostics for Tick-borne Pathogens Using RLB Hybridization and Microarray Based Biochips", University of Pretoria, South Africa
November 2006: Scientific visit at Departamento de Parasitologia, Universidade de Sao Paulo, Instituto de Ciencias Biomedicas (Prof. Dr. Sirlei Daffre) and Departmento de Biochuimica Medica, ICB, Universidade Federal do Rio de Janeiro (Prof. Dr. Pedro L. Oliveira)

Projects solved as principal investigator:

1997-1999: Immune system of a tick: Identification and characterization of proteins involved in clotting and melanization of tick hemolymph (A6022701, Grant Agency, Academy Sciences CR)
2000-2002: Humoral factors and cellular events involved in pathogen transmisson by ticks (206/00/266 Grant Agency CR)
2003-2005: Immune reactions within the gut of the soft tick Ornithodoros moubata (A6022307 Grant Agency, Academy Sciences CR)
2005-2008: The role of ?2-macroglobulin in pathogen transmission by the tick Ixodes ricinus (IAA600220603, Grant Agency, Academy Sciences CR)
2005-2008: Peptidases in the gut of the hard tick Ixodes ricinus: characterization and potential for vector-control (206/060/865, Grant Agency CR)
2009-2011: The digestive system of ticks – the target for rational development of vaccine against tick and tick-borne pathogens (IAA600960910 Grant Agency, Academy Sciences CR)
2010-2012: Functional genomics of the complement-like molecules in the tick Ixodes ricinus (P506/10/2136 Grant Agency CR)

Publications
Total found: 57 records
Urbanová V., Hajdušek O., Hönig Mondeková H., Šíma R., Kopáček P. (2017) Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus Frontiers in Cellular and Infection Microbiology 7 : 73.
DOI: 10.3389/fcimb.2017.00073
Zavašnik-Bergant T., Vidmar R., Sekirnik A., Fonović M., Salát J., Grunclová L., Kopáček P., Turk B. (2017) Salivary tick cystatin OmC2 targets lysosomal cathepsins S and C in human dendritic cells Frontiers in Cellular and Infection Microbiology 7 : 288.
DOI: 10.3389/fcimb.2017.00288
Chmelař J., Kotál J., Karim S., Kopáček P., Francischetti I., Pedra J., Kotsyfakis M. (2016) Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions Trends in Parasitology 32 : 242-254.
DOI: 10.1016/j.pt.2015.10.002
Hajdušek O., Šíma R., Perner J., Loosová G., Harcubová A., Kopáček P. (2016) Tick iron and heme metabolism - New target for an anti-tick intervention Ticks and tick-borne diseases 7 : 565-572.
DOI: 10.1016/j.ttbdis.2016.01.006
Jalovecká M., Bonsergent C., Hajdušek O., Kopáček P., Malandrin L. (2016) Stimulation and quantification of Babesia divergens gametocytogenesis Parasites & Vectors 9 : 439.
DOI: 10.1186/s13071-016-1731-y
de la , Kopáček P., Lew-Tabor A., Maritz-Olivier C. (2016) Strategies for new and improved vaccines against ticks and tick-borne diseases Parasite Immunology 38 : 754-769.
DOI: 10.1111/pim.12339
Kopáček P., Perner J. (2016) Vector Biology: Tyrosine Degradation Protects Blood Feeders from Death via La Grande Bouffe Current Biology 26 : R763-R765.
DOI: 10.1016/j.cub.2016.06.068
Perner J., Provazník J., Schrenková J., Urbanová V., Ribeiro J., Kopáček P. (2016) RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks. Scientific Reports 6 : 36695.
DOI: 10.1038/srep36695
Perner J., Sobotka R., Šíma R., Konvičková J., Sojka D., Lagerblad de Oliveira P., Hajdušek O., Kopáček P. (2016) Acquisition of exogenous haem is essential for tick reproduction eLife 5 : e12318.
DOI: 10.7554/eLife.12318
Schetters T., Bishop R., Crampton M., Kopáček P., Lew-Tabor A., Maritz-Olivier C., Miller R., Mosqueda J., Patarroyo J., Rodriguez-Valle M., Scoles G., de la (2016) Cattle tick vaccine researchers join forces in CATVAC Parasites & Vectors 9 : 105.
DOI: 10.1186/s13071-016-1386-8
Sojka D., Pytelková J., Perner J., Horn M., Konvičková J., Schrenková J., Mareš M., Kopáček P. (2016) Multienzyme degradation of host serum albumin in ticks Ticks and Tick-borne Diseases 7 : 603-613.
DOI: 10.1016/j.ttbdis.2015.12.014
Ayllón N., Naranjo V., Hajdušek O., Villar M., Galindo R., Kocan K., Alberdi P., Šíma R., Cabezas-Cruz A., Rückert C., Bell-Sakyi L., Kazimírová M., Havlíková S., Klempa B., Kopáček P., de la Fuente J. (2015) Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding but Not in Defense against Flaviviral or Anaplasma phagocytophilum Rickettsial Infection PLoS One 10 : e0133038.
DOI: 10.1371/journal.pone.0133038
Ayllón N., Villar M., Galindo R., Kocan K., Šíma R., López J., Vázquez J., Alberdi P., Cabezas-Cruz A., Kopáček P., de la Fuente J. (2015) Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis PLoS Genetics 11 : e1005120.
DOI: 10.1371/journal.pgen.1005120
Kotsyfakis M., Kopáček P., Franta Z., Pedra J., Ribeiro J. (2015) Deep Sequencing Analysis of the Ixodes ricinus Haemocytome PLOS Neglected Tropical Diseases 9 : e0003754.
DOI: 10.1371/journal.pntd.0003754
Urbanová V., Šíma R., Šauman I., Hajdušek O., Kopáček P. (2015) Thioester-containing proteins of the tick Ixodes ricinus: Gene expression, response to microbial challenge and their role in phagocytosis of the yeast Candida albicans Developmental and comparative immunology 48 : 55-64.
DOI: 10.1016/j.dci.2014.09.004
Sprong H., Trentelman J., Seemann I., Grubhoffer L., Rego R. O. M., Hajdušek O., Kopáček P., Nijhof A., Šíma R., Anguita J., Winter P., Rotter B., Havlíková S., Klempa B., Schetters T., Hovius J. (2014) ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe Parasites & Vectors 7 : 77.
DOI: 10.1186/1756-3305-7-77
Urbanová V., Hartmann D., Grunclová L., Šíma R., Flemming T., Hajdušek O., Kopáček P. (2014) IrFC - An Ixodes ricinus injury-responsive molecule related to Limulus Factor C. Developmental and comparative immunology 46 : 439-447.
DOI: 10.1016/j.dci.2014.05.016
Hajdušek O., Šíma R., Ayllón N., Jalovecká M., Perner J., de la Fuente J., Kopáček P. (2013) Interaction of the tick immune system with transmitted pathogens Frontiers in Cellular and Infection Microbiology 3 : 26.
DOI: 10.3389/fcimb.2013.00026
Sojka D., Franta Z., Horn M., Caffrey C., Mareš M., Kopáček P. (2013) New insights into the machinery of blood digestion by ticks Trends in parasitology 29 : 276-285.
DOI: 10.1016/j.pt.2013.04.002
Kopáček P., Hajdušek O., Burešová V. (2012) Tick as a model for the study of a primitive complement system. Advances in Experimental Medicine and Biology 710 : 83–93.
DOI: 10.1007/978-1-4419-5638-5_9

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CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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