RNDr. Ondřej Hajdušek, Ph.D.

Job Position: Head of Laboratory - Laboratory of Tick transmitted diseases

Contact details

Phone: +420 387775496
E-mail: hajdus@paru.cas.cz
Room: 308

Description

Research interests

  • Vaccines against ticks and tick-transmitted diseases
  • Tick innate immunity

Key words: tick, Ixodes, Borrelia, Babesia, Anaplasma, iron, ferritin, innate immunity

Curriculum vitae

Education:    

  • Bachelor program - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic (Biology; Biomedicine laboratory technique)
  • Masters program  - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic (Parasitology)
  • Ph.D. program (graduated 2009) - University of South Bohemia in České Budějovice, Faculty of Science, Czech Republic (Parasitology)
  • Postdoctoral research - Institut de Biologie Moléculaire et Cellulaire (IBMC), CNRS UPR 9022 (Réponse immunitaire et développement chez les Insectes), Strasbourg, France (3 years)

Science visits:

  • 1998 -    PHLS London (UK) - science visit  (1 week)
  • 2001 -    University of Glasgow (UK) - Socrates Erasmus program (4 months)
  • 2005 -    National Research Council of Canada, Ottawa (CAN) - science visit (3 months)
  • 2006 -    Centre National de la Recherche Scientifique, Strasbourg (FRA) - science visit (2 months)

Awards:

  • 2009 -    Dean´s award - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic
  • 2009 -    Rector´s award - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic
  • 2009 -    Scopus Young Researcher Award, Czech Republic

Grants:

  • 2010-2012 -   EMBO Long Term Fellowship
  • 2013-2015 -   Grant agency of the Czech republic (GACR) - 13-27630P
  • 2013-2015 -   MODBIOLIN, 7FP, GA No. 316304
  • 2014-2018 -    ANTIDotE, 7FP EU
  •  

Publications
Total found: 22 records
Urbanová V., Hajdušek O., Šíma R., Franta Z., Grunclová L., Hönig Mondeková H., Bartošová-Sojková P., Jalovecká M., Kopáček P. (2018) IrC2/Bf e A yeast and Borrelia responsive component of the complement system from the hard tick Ixodes ricinus Developmental and Comparative Immunology 79 : 86-94.
DOI: 10.1016/j.dci.2017.10.012
Urbanová V., Hajdušek O., Hönig Mondeková H., Šíma R., Kopáček P. (2017) Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus Frontiers in Cellular and Infection Microbiology 7 : 73.
DOI: 10.3389/fcimb.2017.00073
Aase A., Hajdušek O., Øines Ø., Quarsten H., Wilhelmsson P., Herstad T., Kjelland V., Šíma R., Jalovecká M., Lindgren P., Aaberg I. (2016) Validate or falsify: Lessons learned from a microscopy method claimed to be useful for detecting Borrelia and Babesia organisms in human blood Infectious Diseases 48 : 411-419.
DOI: 10.3109/23744235.2016.1144931
Hajdušek O., Šíma R., Perner J., Loosová G., Harcubová A., Kopáček P. (2016) Tick iron and heme metabolism - New target for an anti-tick intervention Ticks and tick-borne diseases 7 : 565-572.
DOI: 10.1016/j.ttbdis.2016.01.006
Jalovecká M., Bonsergent C., Hajdušek O., Kopáček P., Malandrin L. (2016) Stimulation and quantification of Babesia divergens gametocytogenesis Parasites & Vectors 9 : 439.
DOI: 10.1186/s13071-016-1731-y
Perner J., Sobotka R., Šíma R., Konvičková J., Sojka D., Lagerblad de Oliveira P., Hajdušek O., Kopáček P. (2016) Acquisition of exogenous haem is essential for tick reproduction eLife 5 : e12318.
DOI: 10.7554/eLife.12318
Ayllón N., Naranjo V., Hajdušek O., Villar M., Galindo R., Kocan K., Alberdi P., Šíma R., Cabezas-Cruz A., Rückert C., Bell-Sakyi L., Kazimírová M., Havlíková S., Klempa B., Kopáček P., de la Fuente J. (2015) Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding but Not in Defense against Flaviviral or Anaplasma phagocytophilum Rickettsial Infection PLoS One 10 : e0133038.
DOI: 10.1371/journal.pone.0133038
Urbanová V., Šíma R., Šauman I., Hajdušek O., Kopáček P. (2015) Thioester-containing proteins of the tick Ixodes ricinus: Gene expression, response to microbial challenge and their role in phagocytosis of the yeast Candida albicans Developmental and comparative immunology 48 : 55-64.
DOI: 10.1016/j.dci.2014.09.004
Golovchenko M., Šíma R., Hajdušek O., Grubhoffer L., Oliver J., Rudenko N. (2014) Invasive potential of Borrelia burgdorferi sensu stricto ospC type L strains increases the possible disease risk to humans in the regions of their distribution. Parasites & Vectors 7 : 538.
DOI: 10.1186/s13071-014-0538-y
Sprong H., Trentelman J., Seemann I., Grubhoffer L., Rego R. O. M., Hajdušek O., Kopáček P., Nijhof A., Šíma R., Anguita J., Winter P., Rotter B., Havlíková S., Klempa B., Schetters T., Hovius J. (2014) ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe Parasites & Vectors 7 : 77.
DOI: 10.1186/1756-3305-7-77
Urbanová V., Hartmann D., Grunclová L., Šíma R., Flemming T., Hajdušek O., Kopáček P. (2014) IrFC - An Ixodes ricinus injury-responsive molecule related to Limulus Factor C. Developmental and comparative immunology 46 : 439-447.
DOI: 10.1016/j.dci.2014.05.016
Hajdušek O., Šíma R., Ayllón N., Jalovecká M., Perner J., de la Fuente J., Kopáček P. (2013) Interaction of the tick immune system with transmitted pathogens Frontiers in Cellular and Infection Microbiology 3 : 26.
DOI: 10.3389/fcimb.2013.00026
Kopáček P., Hajdušek O., Burešová V. (2012) Tick as a model for the study of a primitive complement system. Advances in Experimental Medicine and Biology 710 : 83–93.
DOI: 10.1007/978-1-4419-5638-5_9
Burešová V., Hajdušek O., Franta Z., Loosová G., Grunclová L., Levashina E., Kopáček P. (2011) Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system. Journal of Innate Immunity 3 : 623–630.
DOI: 10.1159/000328851
Hajdušek O., Almazán C., Loosová G., Villar M., Canales M., Grubhoffer L., Kopáček P., de la Fuente J. (2010) Characterization of ferritin 2 for the control of tick infestations. Vaccine 28 : 2993–2998.
DOI: 10.1016/j.vaccine.2010.02.008
Burešová V., Hajdušek O., Franta Z., Sojka D., Kopáček P. (2009) IrAM-An alpha2-macroglobulin from the hard tick Ixodes ricinus: characterization and function in phagocytosis of a potential patogen Chryseobacterium indologenes Developmental and Comparative Immunology 33 : 489-498.
DOI: 10.1016/j.dci.2008.09.011
Hajdušek O., Sojka D., Kopáček P., Burešová V., Franta Z., Šauman I., Winzerling J., Grubhoffer L. (2009) Knockdown of proteins involved in iron metabolism limits tick reproduction and development. PNAS USA 106 : 1033-1038.
DOI: 10.1073/pnas.0807961106

Documents to download:
2009-PNAS (pdf)
Sojka D., Franta Z., Horn M., Hajdušek O., Caffrey C., Mareš M., Kopáček P. (2008) Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasites & Vectors 0-0.
DOI: 10.1186/1756-3305-1-7
Sojka D., Hajdušek O., Dvořák J., Sajid M., Franta Z., Schneider E., Craik C., Vancová M., Burešová V., Bogyo M., Sexton K., Mc Kerrow J., Caffrey C., Kopáček P. (2007) IrAE – An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. International Journal for Parasitology 37 : 713-724.
DOI: 10.1016/j.ijpara.2006.12.020
Rego R. O. M., Hajdušek O., Kovář V., Kopáček P., Grubhoffer L., Hypša V. (2005) Molecular cloning and comparative analysis of fibrinogen-related proteins from the soft tick Ornithodoros moubata and the hard tick Ixodes ricinus. Insect Biochemistry and Molecular Biology 35 : 991-1004.
DOI: 10.1016/j.ibmb.2005.04.001

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CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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