RNDr. Lenka Grunclová, Ph.D.

Job Position: Professional staff - Laboratory of Vector Immunology

Contact details

Phone: +420 387775489, +420 387775476
E-mail: ferda@paru.cas.cz
Room: 338

Description

Immune-related molecules of the tick Ixodes ricinus.

Curriculum vitae

Date of birth:   18.6.1977, Karlovy Vary

Education and professional experience:

 

  • 2002-2007: PhD program Molecular and cell biology and genetics, Faculty of Biological Science University of South Bohemia, České Budějovice, Czech Republic
  • 1999-2001: Master program Genetic a genetic engineering, Faculty of Biological Science University of South Bohemia, České Budějovice, Czech Republic
  • 1995-1999: Bachelor program Plant biotechnology, Faculty of Biological Science University of South Bohemia, České Budějovice, Czech Republic
  • 2001- presence: Laboratory of vector immunology, Instituteof   Parasitology, Biology centre of the Academy of Science of the Czech Republic, v. v. i., České Budějovice
  • September 2006: 1 month stay in the lab of Kozo Fujisaki, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro,  Japan

Publications:

  • Burešová V., Hajdušek O., Franta Z., Loosová G., Grunclová L., Levashina E.A., Kopáček P. (2011) Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system. Journal of Innate Immunity 3: 623–630.
  • Salát J., Paesen G.C., Řezáčová P., Kotsyfakis M., Kovářová Z., Šanda M., Majtán J., Grunclová L., Horká H., Andersen J.F., Brynda J., Horn M., Nunn M.A., Kopáček P., Kopecký J., Mareš M. (2010) Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata. Biochemical Journal 429: 103–112.
  • Grunclová, L., Horn, M., Vancová, M., Sojka, D., Franta, Z., Mareš, M., Kopáček, P. (2006). Two secreted cystatins of the soft tick Ornithodoros moubata: differential expression pattern and inhibitory specificity. Biol. Chem. 387: 1635-1644.
  • Grunclová, L., Fouquier, H., Hypša, V., Kopáček, P.  (2003). Lysozyme from the gut of the soft tick Ornithodoros moubata: the sequence, phylogeny and post-feeding regulation. Dev. Comp. Immunol. 27: 651-660.
  • Presentations and meetings:

Oral presentations:

  • The 15th Japanese-German Symposium on Protozoan Diseases, Obihiro, Japan (September 2006). Grunclová L., Horn M., Vancová M., Sojka D., Franta Z., Mareš M., Kopáček P.: Inhibitors of cysteine peptidases in the gut and salivary glands of the soft tick Ornithodoros moubata.
  • Czech Society of Protozoologists, 35th annual meeting-Nové Hrady, Czech Republic (May 2005). Grunclová L., Vancová M., Mareš M., Sojka D., Kopáček P.: Cysteine proteases inhibitors in the gut of the soft tick Ornithodoros moubata.

Poster presentations:

  • 5th International Symposium on Molecular Insect Science, Tucson, Arizona, USA (May 2006). Grunclová L., Horn M., Vancová M., Franta Z., Mareš .M., Kopáček P.: Inhibitors of cysteine peptidases in the soft tick Ornithodoros moubata.
  • 5th International conference on cysteine proteinases and their Inhibitors: from structure to regulation and biology, Portorož, Slovenia (September 2006). Horn M., Franta Z., Grunclová L., Vancová M., Sojka D., Mareš M., Kopáček P.: Tick cysteine peptidases and their endogenous inhibitors.
  • 5th International Conference on Ticks and Tick-Borne Pathogens, Neuchatel, Switzerland, (September 2005). Grunclová L., Vancová M., Mareš M., Sojka D., Kopáček P.:  Cysteine protease inhibitors in the midgut of the soft tick Ornithodoros moubata
  • XXII Congress of Entomology, Brisbane, Queensland, Australia August (2004). Kopáček P., Kovář V., Grunclová L., Saravanan T., Šauman I., Weise C., Grubhoffer L.: Immune proteins in the soft tick Ornithodoros moubata.

Publications
Total found: 7 records
Urbanová V., Hajdušek O., Šíma R., Franta Z., Grunclová L., Hönig Mondeková H., Bartošová-Sojková P., Jalovecká M., Kopáček P. (2018) IrC2/Bf e A yeast and Borrelia responsive component of the complement system from the hard tick Ixodes ricinus Developmental and Comparative Immunology 79 : 86-94.
DOI: 10.1016/j.dci.2017.10.012
Zavašnik-Bergant T., Vidmar R., Sekirnik A., Fonović M., Salát J., Grunclová L., Kopáček P., Turk B. (2017) Salivary tick cystatin OmC2 targets lysosomal cathepsins S and C in human dendritic cells Frontiers in Cellular and Infection Microbiology 7 : 288.
DOI: 10.3389/fcimb.2017.00288
Urbanová V., Hartmann D., Grunclová L., Šíma R., Flemming T., Hajdušek O., Kopáček P. (2014) IrFC - An Ixodes ricinus injury-responsive molecule related to Limulus Factor C. Developmental and comparative immunology 46 : 439-447.
DOI: 10.1016/j.dci.2014.05.016
Burešová V., Hajdušek O., Franta Z., Loosová G., Grunclová L., Levashina E., Kopáček P. (2011) Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system. Journal of Innate Immunity 3 : 623–630.
DOI: 10.1159/000328851
Salát J., Paesen G., Řezáčová P., Kotsyfakis M., Kovářová Z., Šanda M., Majtán J., Grunclová L., Horká H., Andersen J., Brynda J., Horn M., Nunn M., Kopáček P., Kopecký J., Mareš M. (2010) Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata. Biochemical Journal 429 : 103–112.
DOI: 10.1042/BJ20100280
Grunclová L., Horn M., Vancová M., Sojka D., Franta Z., Mareš M., Kopáček P. (2006) Two secreted cystatins of the soft tick Ornithodoros moubata: differential expression pattern and inhibitory specificity. Biological Chemistry 387 : 1635-1644.
DOI: 10.1515/BC.2006.204
Grunclová L., Fouquier H., Hypša V., Kopáček P. (2003) Lysozyme from the gut of the soft tick Ornithodoros moubata: the sequence, phylogeny and post-feeding regulation. Developmental and Comparative Immunology 27 : 651-660.
DOI: 10.1016/S0145-305X(03)00052-1

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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