RNDr. Martin Palus, Ph.D.

Job Position: PostDoc - Laboratory of Arbovirology

Contact details

Phone: +420 387775463
E-mail: palus@paru.cas.cz
Room: 324

Description

Research interests

In flavivirus encephalitis, the outcome and clinical manifestation is associated with the damage of the brain. Three possible mechanisms of brain tissue destruction have been postulated. Firstly, the virus itself causes direct neuronal damage; secondly, the neuronal death is caused by virus-induced inflammatory response (immunopathology); and finally, a combination of both plays a role.

The topic of my PhD thesis is immunopatology and immunopathogenesis of TBE. For this study we use recombinant congenic strains of mice. In vitro models of the blood-brain barrier are used  as well with the purpose to simulate a breakdown during the infection.

Curriculum vitae

Education

Faculty of Science, University of South Bohemia

  • 2012-now: Ph.D.(Molecular and Cellular Biology and Genetics); PhD thesis: Molecular aspects of immunopathogenesis of tick-borne diseases
  • 2009-2012: MSc. (Clinical Biology); Master thesis: The role of genetic background of the host on the pathogenesis of tick-borne encephalitis
  • 2007-2009: BSc. (Biology-Biomedical Laboratory Techniques); Bachelor thesis: Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background
  • 2006-2009: BSc. (Biology); Bachelor thesis: Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background

Employment

  • 2011-now: Assistant Biology Centre, Academy of the Sciences of the Czech Republic, Institute of Parasitology, Dept. of Parasite Immunology (part-time job)
  • 2011-2012: Assistant, The National Institute for Nuclear, Chemical and Biological Protection (part-time job)
  • 2009: Assistant Biology Centre, Academy of the Sciences of the Czech Republic, Institute of Parasitology, Dept. of Parasite Immunology (part-time job)

Research internships

  • 2011 (Erasmus Programme) The Univetsity of Edinburgh; The Roslin Institute and Royal (Dick) School of Veterinary Studies

Conferences

  • Hönig V., Švec P., Masař O., Kilian P., Dorňáková V., Dupejová J., Palus M., Vavrušková Z., Grubhoffer L. (2011): Ticks and tick-borne disease research in South Bohemia with the use of GIS. XI  International Jena Symposium on Tick-Borne Diseases 2011, Weimar, Germany, p. 96, Poster P28.
  • Hönig V., Švec P., Masař O., Kilian P., Dorňáková V., Dupejová J., Palus M., Vavrušková Z, Grubhoffer L. (2010): Ticks and tick-borne diseases in conditions of South Bohemia (Czech Republic), 12th ICLB, Ljubljana, Slovenia,  p. 64-65, Poster P49.
  • Sterba J., Dupejova J., Vancova M., Palus M., Bell-Sakyi L., Grubhoffer L (2011): Ornithodoros moubata cell culture producing the tick lectin, Dorin M. Ticks and Tick-borne Pathogens Conference 7 (TTP7), Zaragoza.

Publications
Total found: 13 records
Elsterová J., Palus M., Širmarová J., Kopecký J., Niller H., Růžek D. (2017) Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin Ticks and Tick-borne Diseases 8 : 253-258.
DOI: 10.1016/j.ttbdis.2016.11.007
Eyer L., Kondo H., Zouharova D., Hirano M., Valdés J. J., Muto M., Kasti T., Kobayashi S., Haviernik J., Igarashi M., Kariwa H., Vaculovicova M., Černý J., Kizek R., Kröger A., Lienenklaus S., Dejmek M., Nencka R., Palus M., Salát J., De Clercq E., Yoshii K., Růžek D. (2017) Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness Journal of Virology 91 : e01028-17.
DOI: 10.1128/JVI.01028-17
Palus M., Vancová M., Širmarová J., Elsterová J., Perner J., Růžek D. (2017) Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity. Virology 507 : 110-122.
DOI: 10.1016/j.virol.2017.04.012
Černý J., Selinger M., Palus M., Vavrušková Z., Tykalová H., Bell-Sakyi L., Štěrba J., Grubhoffer L., Růžek D. (2016) Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells Virus Genes 52 : 309-316.
DOI: 10.1007/s11262-015-1273-y
Eyer L., Nencka R., Huvarová I., Palus M., Alves M., Gould E., De Clercq E., Růžek D. (2016) Nucleoside inhibitors of Zika virus Journal of Infectious Diseases 214 : 707-711.
DOI: 10.1093/infdis/jiw226
Eyer L., Šmídková M., Nencka R., Neča J., Kastl T., Palus M., De Clercq E., Růžek D. (2016) Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus Antiviral Research 133 : 119-129.
DOI: 10.1016/j.antiviral.2016.07.018
Bílý T., Palus M., Eyer L., Elsterová J., Vancová M., Růžek D. (2015) Electron tomography analysis of tick-borne encephalitis virus infection in human neurons Scientific Reports 5 : 10745.
DOI: 10.1038/srep10745
Eyer L., Valdés J. J., Gil V., Nencka R., Hřebabecký H., Šála M., Salát J., Černý J., Palus M., De Clercq E., Růžek D. (2015) Nucleoside inhibitors of tick-borne encephalitis virus Antimicrobial Agents and Chemotherapy 59 : 5483-5493.
DOI: 10.1128/AAC.00807-15
Palus M., Formanová P., Salát J., Žampachová E., Elsterová J., Růžek D. (2015) Analysis of serum levels of cytokines, chemokines, growth factors, and monoamine neurotransmitters in patients with tick-borne encephalitis: Identification of novel inflammatory markers with implications for pathogenesis Journal of Medical Virology 87 : 885-892.
DOI: 10.1002/jmv.24140
Palus M., Bílý T., Elsterová J., Langhansová H., Salát J., Vancová M., Růžek D. (2014) Infection and injury of human astrocytes by tick-borne encephalitis virus JOURNAL OF GENERAL VIROLOGY 95 : 2411-2426.
DOI: 10.1099/vir.0.068411-0
Palus M., Žampachová E., Elsterová J., Růžek D. (2014) Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in patients with tick-borne encephalitis Journal of Infection 68 : 165-169.
DOI: 10.1016/j.jinf.2013.09.028
Palus M., Vojtíšková M., Salat J., Kopecký J., Grubhoffer L., Lipoldová M., Demant P., Růžek D. (2013) Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system Jornal of neuroinflammation 10 : 77.
Růžek D., Salát J., Palus M., Gritsun T., Gould E., Dyková I., Skallová A., Jelínek J., Kopecký J., Grubhoffer L. (2009) CD8+ T-cells mediate immunopathology in tick-borne encephalitis. Virology 384 : 1-6.
DOI: 10.1016/j.virol.2008.11.023

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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