RNDr. Alena Panicucci Zíková, Ph.D.

Funkce: Vedoucí laboratoře - Laboratoř funkční biologie protist

Kontaktní údaje

Telefon: +420 387775482
E-mail: azikova@paru.cas.cz
Místnost: PARU II, 2.06

Popis

Research interests

  • unique properties of the mitochondrial respiratory complexes in Trypanosoma brucei andLeishmania spp.
  • screening chemical compounds that inhibit enzymes of the purine salvage pathway, thus validating this pathway as a drug target
Odborný životopis

Informace v anglické verzi.

Výuka Biochemie a molekulární biologie parazitů / Biochemistry and molecular biology of parasites
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Pokročilé metody molekulární biologie / Advanced Methods in Molecular Biology
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Molekulární biologie / Molecular Biology of Cell
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Publikace
Celkem nalezeno: 30 záznamů
Doleželová E., Terán D., Gahura O., Kotrbová Z., Procházková M., Keough D., Špaček P., Hocková D., Guddat L., Zíková A. (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery PLOS Neglected Tropical Disesases 12 : e0006301.
DOI: 10.1371/journal.pntd.0006301
Gahura O., Šubrtová K., Váchová Hana, Panicucci B., Fearnley Ian M., Harbour Michael E., Walker John E., Zíková A. (2018) The F1 -ATPase from Trypanosoma brucei is elaborated by three copies of an additional p18-subunit FEBS Journal 285 : 614-628.
DOI: 10.1111/febs.14364
Montgomery M.G., Gahura O., Leslie A.G., Zíková A., Walker J.E. (2018) ATP synthase from Trypanosoma brucei has an elaborated canonical F1-domain and conventional catalytic sites. Proceedings of the National Academy of Sciences of the United States of America 115 : 2102-2107.
DOI: 10.1073/pnas.1720940115
Procházková M., Panicucci B., Panicucci Zíková A. (2018) Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1 Scientific Reports 8 : 5135.
DOI: 10.1038/s41598-018-23472-6
Panicucci B., Gahura O., Zíková A. (2017) Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite PloS Neglected Tropical Diseases 11 : e0005552.
DOI: 10.1371/journal.pntd.0005552
Zíková A., Verner Z., Nenarokova A., Michels P.A.M., Lukeš J. (2017) A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex PLOS Pathogens 13 : e1006679.
DOI: 10.1371/journal.ppat.1006679

Dokumenty ke stažení:
Zikova et al. 2017 PLOS Pathogens (pdf)
Alkhaldi A., Martinek J., Panicucci B., Dardonville C., Zíková A., de Koning H. (2016) Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei International Journal for Parasitology: Drugs and Drug Resistance 6 : 23-34.
DOI: 10.1016/j.ijpddr.2015.12.002
Hashimi H., Kaltenbrunner S., Zíková A., Lukeš J. (2016) Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet PLoS Pathogens 12 : e1005492.
DOI: 10.1371/journal.ppat.1005492

Dokumenty ke stažení:
Hashimi et al. 2016 PLoS Pathog (pdf)
Terán D., Hocková D., Česnek M., Zíková A., Naesens L., Keough D., Guddat L. (2016) Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase Scientific Reports 6 : 35894.
DOI: 10.1038/srep35894
Zíková A., Hampl V., Paris Z., Týč J., Lukeš J. (2016) Aerobic mitochondria of parasitic protists: diverse genomes and complex functions. Molecular and Biochemical Parasitology 209 : 46-57.
DOI: 10.1016/j.molbiopara.2016.02.007

Dokumenty ke stažení:
Zikova et al. 2016 MBP (pdf)
Gnipová A., Šubrtová K., Panicucci B., Horváth A., Lukeš J., Zíková A. (2015) The ADP/ATP carrier and its relationship to OXPHOS in an ancestral protist, Trypanosoma brucei. Eukaryotic Cells 14 : 297-310.
DOI: 10.1128/EC.00238-14

Dokumenty ke stažení:
Gnipova et al. 2015 ECell (pdf)
Šubrtová K., Panicucci B., Zíková A. (2015) ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes Plos Pathogens 10 : e1004660.
DOI: 10.1371/journal.ppat.1004660
Verner Z., Basu S., Benz C., Dixit S., Dobáková E., Faktorová D., Hashimi H., Horáková E., Huang Z., Paris Z., Pena P., Ridlon L., Týč J., Wildridge D., Zíková A., Lukeš J. (2015) The malleable mitochondrion of Trypanosoma brucei Internation Review of Cell and Molecular Biology 315 : 73-151.
DOI: 10.1016/bs.ircmb.2014.11.001

Dokumenty ke stažení:
Verner-IRCMB-2015 (pdf)
Zíková A., Oborník M., Lukeš J. (2015) Fancy a gene? A surprisingly complex evolutionary history of peroxiredoxins. Microbial Cell 2 : 5-13.
DOI: 10.15698/mic2015.02.189

Dokumenty ke stažení:
Zikova et al. 2015 (pdf)
Gnipová A., Panicucci B., Paris Z., Verner Z., Horváth A., Lukeš J., Zíková A. (2012) Disparate phenotypic effects from the knockdown of various Trypanosoma brucei cytochrome c oxidase subunits. Molecular and Biochemical Parasitology 184 : 90-98.
DOI: 10.1016/j.molbiopara.2012.04.013

Dokumenty ke stažení:
2012_Gnipova_MBP_90 (pdf)
Acestor N., Zíková A., Dalley R., Anupama A., Panigrahi A., Stuart K. (2011) Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form. Molecular & Cellular Proteomics 10 : 9.
DOI: 10.1074/mcp.M110.006908
Paris Z., Changmai P., Rubio M., Zíková A., Stuart K., Alfonzo J., Lukeš J. (2010) The Fe/S Cluster assembly protein Isd11 is essential for tRNA thiolation in Trypanosoma brucei. Journal of Biological Chemistry 285 : 22394–22402.
DOI: 10.1074/jbc.M109.083774

Dokumenty ke stažení:
Paris et al. 2010 JBCh (pdf)
Poliak P., Van Hoewyk D., Oborník M., Zíková A., Stuart K., Tachezy J., Pilon M., Lukeš J. (2010) Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei. FEBS Journal 277 : 383–393.
DOI: 10.1111/j.1742-4658.2009.07489.x

Dokumenty ke stažení:
Poliak et al. 2010 FEBS (pdf)
Acestor N., Panigrahi A., Carnes J., Zíková A., Stuart K. (2009) The MRB1 complex functions in kinetoplastid RNA. RNA 15 : 277-286.
Panigrahi A., Ogata Y., Zíková A., Anupama A., Dalley R., Acestor N., Myler P., Stuart K. (2009) a comprehensive analysis of Trypanosoma brucei mitochondrial proteome. Proteomics 9 : 434-450.
DOI: 10.1002/pmic.200800477

Více publikací

KONTAKT

Biologické centrum AV ČR, v.v.i.
Parazitologický ústav
Branišovská 1160/31
370 05 České Budějovice

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