Mgr. Ondřej Gahura, Ph.D.

Funkce: PostDok - Laboratoř funkční biologie protist

Kontaktní údaje

Telefon: +420 387755429
E-mail: gahura@paru.cas.cz
Místnost: PARU II, 2.05

Popis

Ondrej Gahura on ResearchGate

V rámci projektu se zabýváme funkční  a strukturní analýzou mitochondriálního komplexu FoF1 ATPázy u parazitického bičíkovce Trypanosoma brucei, původce spavé nemoci.  Jelikož funkce, kompozice a aktivita tohoto komplexu je rozdílná od komplexu savčího,  je FoF1 ATPáza studována za účelem vývoje inhibitorů a potenciálních chemoterapeutik.

Odborný životopis

2013 - present           Postdoctoral associate, Institute of Parasitology, Biology Centre CAS, Ceske Budejovice (Dr. A. Zikova)

2013-2017                 Visiting scientist, Mitochondrial Biology Unit, MRC, Cambridge, UK (Sir John Walker, 18 months in total)

2012                           Research associate, Faculty of Science, University of Geneva, Switzerland (Prof. F. Stutz, 3 months)

2006-2012                  Research assistant, Faculty of Science, Charles University in Prague, Czech Republic (Dr. P. Folk)

2012                           Ph.D. in Molecular and Cell Biology, Genetics and Virology, Charles University in Prague, Czech Republic (Dr. P. Folk)

2006                           M.Sc. in Biological Sciences, Faculty of Science, Charles University in Prague, Czech Republic (Dr. P. Folk)

 

Výuka Epigenetika a regulace genové exprese
Přírodovědecká fakulta JČU, České Budějovice

Publikace
Celkem nalezeno: 9 záznamů
Doleželová E., Terán D., Gahura O., Kotrbová Z., Procházková M., Keough D., Špaček P., Hocková D., Guddat L., Zíková A. (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery PLOS Neglected Tropical Disesases 12 : e0006301.
DOI: 10.1371/journal.pntd.0006301
Gahura O., Šubrtová K., Váchová Hana, Panicucci B., Fearnley Ian M., Harbour Michael E., Walker John E., Zíková A. (2018) The F1 -ATPase from Trypanosoma brucei is elaborated by three copies of an additional p18-subunit FEBS Journal 285 : 614-628.
DOI: 10.1111/febs.14364
Montgomery M.G., Gahura O., Leslie A.G., Zíková A., Walker J.E. (2018) ATP synthase from Trypanosoma brucei has an elaborated canonical F1-domain and conventional catalytic sites. Proceedings of the National Academy of Sciences of the United States of America 115 : 2102-2107.
DOI: 10.1073/pnas.1720940115
Halova Martina, Gahura O., Převorovský Martin, Cit Zdeněk, Novotný Marian, Valentova Anna, Abrhamova Katerina, Půta František, Folk Petr (2017) Nineteen complex-related factor Prp45 is required for the early stages of cotranscriptional spliceosome assembly RNA DOI: 10.1261/rna.061986.117
Panicucci B., Gahura O., Zíková A. (2017) Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite PloS Neglected Tropical Diseases 11 : e0005552.
DOI: 10.1371/journal.pntd.0005552
Musilova Z., Rican O., Ricanova S., Jansta P., Gahura O., Novak J. (2015) Phylogeny and historical biogeography of trans-Andean cichlid fishes (Teleostei: Cichlidae) Vertebrate Zoology
Wang X., Wu F., Xie Q., Wang H., Yue Y., Gahura O., Ma S., Liu L., Cao Y., Jiao Y., Puta F., McClung CR, Xu X., Ma Ligeng (2012) SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis Plant Cell DOI: 10.1105/tpc.112.100081
Gahura O., Hammann Christian, Valentova Anna, Puta Frantisek, Folk Petr (2011) Secondary structure is required for 3' splice site recognition in yeast Nucleic Acids Research DOI: 10.1093/nar/gkr662
Gahura O., Abrhamova Katerina, Skurzny Michal, Valentova Anna, Valentova Anna, Munzarova Vanda, Folk Petr, Puta Frantisek (2009) Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates Journal of Cellular Biochemistry DOI: 10.1002/jcb.21989

KONTAKT

Biologické centrum AV ČR, v.v.i.
Parazitologický ústav
Branišovská 1160/31
370 05 České Budějovice

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