Alexandra Schwarz, Ph.D.

Funkce: Vědecký pracovník - Laboratoř genomiky a proteomiky vektorů

Kontaktní údaje

Telefon: 420387775491
E-mail: schwarz@paru.cas.cz
Místnost: 614

Odborný životopis

Vzdělání

  • 2009 PhD titul z parazitologie, University of Aberdeen, UK a Ruhr-University of Bochum, Německo
  • 2004 Mgr. titul z biologie se zaměřením na lékařskou parazitologii, zoologii, mikrobiologii, ekologii a lékařskou geografii, University of Bonn, Německo

Pracovní zkušenosti

  • Od roku 2010 Postgraduální vědecký pracovník, Laboratoř genomiky a proteomiky vektorů, Parazitologický ústav, BC AV ČR
  • 12/2009 Postgraduální vědecký pracovník, Laboratory of Eco-Epidemiology, Universidad de Buenos Aires, Buenos Aires, Argentina: Analysis of antibody responses of dogs from endemic Chagas disease areas to salivary proteins of T. infestans
  • 11/2009 Postgraduální vědecký pracovník, Unidad de Enfermedades Infecciosas, Laboratorio de Immunologia, Universidad Peruana Cayetano Heredia, Lima, Peru: Analysis of antibody responses of guinea pigs to saliva of T. infestans for the evaluation of an impregnated netting trial
  • 01 – 04/2008 Hostující vědecký pracovník, LMVR, NIH, Rockville, USA: Heterologous synthesis of recombinant salivary proteins of T. infestans
  • 09 – 11/2007 Hostující vědecký pracovník, Laboratory of Chagas disease and Immunoparasitology, Universidad Mayor de San Simón, Cochabamba, Bolívie: Epidemiological field study of T. infestans infestation in urban households of Bolivia
  • 05 – 07/2006 Hostující vědecký pracovník, Laboratory of Malaria and Vector Research (LMVR), National Institutes of Health (NIH), Rockville, USA: Heterologous synthesis of recombinant salivary proteins of T. infestans

Publikace

  • Schwarz, A, Medrano-Mercado, N, Billingsley, PF, Schaub, GA, Sternberg, JM (2010). IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines. Int. J. Parasitol. 40: 1295-1302.
  • Schwarz, A, Helling, S, Collin, N, Teixeira, CR, Medrano-Mercado, N, Hume, JCC, Assumpçao, TC, Marcus, K, Stephan, C, Meyer, HE, Ribeiro, JM, Billingsley, PF, Valenzuela, JG, Sternberg, JM, Schaub, GA. (2009). Immunogenic salivary proteins of Triatoma infestans: Development of a recombinant antigen for the detection of low-level infestation of triatomines. PLoS Negl. Trop. Dis. 3: e532. doi:10.1371/journal.pntd.0000532.
  • Schwarz, A, Sternberg, JM, Johnston, V, Medrano-Mercado, N, Anderson, JM, Hume, JCC, Valenzuela, JG, Schaub, GA, Billingsley, PF (2009) Antibody responses of domestic animals to salivary antigens of Triatoma infestans as biomarkers for low-level infestation of triatomines. Int. J. Parasitol. Int. J. Parasitol. 39:1021-1029.
  • Schwarz, A, Maier, WA, Kistemann, T, Kampen, H (2009) Analysis of the distribution of the tick Ixodes ricinus L. (Acari: Ixodidae) in a nature reserve of western Germany using Geographic Information Systems. Int. J. Hyg. Environ. Health. 212:87-96.
  • Assumpcao,TCF, Francischetti, IMB, Andersen,JF, Schwarz,A, Santana,JM, Ribeiro,JMC (2008) An insight into the sialome of the blood sucking bug, Triatoma infestans. Insect. Biochem. Mol. Biol. 38:213-232.
  • Schwarz, A, Maier, WA, Kampen, H (2004) A GIS-based study on the population dynamics of Ixodes ricinus in the Siebengebirge near Bonn. Int. J. Med. Microbiol. Suppl. 293 (Suppl. 38): 56

Publikace
Celkem nalezeno: 14 záznamů
Hackenberg M., Langenberger D., Schwarz A., Erhart J., Kotsyfakis M. (2017) In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology RNA 23 : 1259-1269.
DOI: 10.1261/rna.061168
Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J. (2015) Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host Scientific reports 5 : 9103.
DOI: 10.1038/srep09103
Ribeiro J., Schwarz A., Francischetti I. (2015) A Deep Insight Into the Sialotranscriptome of the Chagas Disease Vector, Panstrongylus megistus (Hemiptera: Heteroptera). Journal of medical entomology 52 : 351-358.
DOI: 10.1093/jme/tjv023
Dorňáková V., Salazar-Sanchez R., Borrini-Mayori K., Carrion-Navarro O., Levy M., Schaub G., Schwarz A. (2014) Characterization of Guinea Pig Antibody Responses to Salivary Proteins of Triatoma infestans for the Development of a Triatomine Exposure Marker. PLoS Neglected Tropical Diseases 8 : e2783.
DOI: 10.1371/journal.pntd.0002783
Schwarz A., Cabezas-Cruz A., Kopecký J., Valdés J. J. (2014) Understanding the evolutionary structural variability and target specificity of tick salivary peptides using next generation transcriptome data. BMC Evolutionary Biology 14 : DOI: 10.1186/1471-2148-14-4
Schwarz A., Medrano-Mercado N., Schaub G., Struchiner C., Bargues M., Levy M., Ribeiro J. (2014) An Updated Insight into the Sialotranscriptome of Triatoma infestans: Developmental Stage and Geographic Variations PLoS neglected tropical diseases 8 : e3372.
DOI: 10.1371/journal.pntd.0003372
Schwarz A., Tenzer S., Hackenberg M., Erhart J., Gerhold-Ay A., Mazur J., Kuharev J., Ribeiro J., Kotsyfakis M. (2014) A systems level analysis reveals transcriptomic and proteomic complexity in Ixodes ricinus midgut and salivary glands during early attachment and feeding MOLECULAR & CELLULAR PROTEOMICS 13 : 2725-2735.
DOI: 10.1074/mcp.M114.039289
Assumpçao T., Ma D., Schwarz A., Reiter K., Santana J., Andersen J., Ribeiro J., Nardone G., Yu L., Francischetti I. (2013) Salivary Antigen-5/CAP Family Members Are Cu2+-dependent Antioxidant Enzymes That Scavenge OFormula and Inhibit Collagen-induced Platelet Aggregation and Neutrophil Oxidative Burst. Journal of biological chemistry 288 : 14341-14361.
DOI: 10.1074/jbc.M113.466995
Schwarz A., Von Reumont B., Erhart J., Chagas A., Ribeiro J., Kotsyfakis M. (2013) De novo Ixodes ricinus salivary gland transcriptome analysis using two next-generation sequencing methodologies FASEB JOURNAL 27 : 4745-4756.
DOI: 10.1096/fj.13-232140
Valdés J. J., Schwarz A., Cabeza De Vaca I., Calvo E., Pedra J., Guallar V., Kotsyfakis M. (2013) Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder PloS ONE 8 : e62562.
DOI: 10.1371/journal.pone.0062562
Schwarz A., Hönig V., Vavrušková Z., Grubhoffer L., Balczun C., Albring A., Schaub G. (2012) Abundance of Ixodes ricinus and prevalence of Borrelia burgdorferi s.l. in the nature reserve Siebengebirge, Germany, in comparison to three ormer studies from 1978 onwards. Parasites & vectors 5 : 268.
DOI: 10.1186/1756-3305-5-268
Schwarz A., Valdés J. J., Kotsyfakis M. (2012) The role of cystatins in tick physiology and blood feeding. Ticks and Tick-borne Diseases 3 : 117-127.
DOI: 10.1016/j.ttbdis.2012.03.004
Schwarz A., Juarez J., Richards J., Rath B., Machaca V., Castro Y., Málaga E., Levy K., Gilman R., Bern C., Verastegui M., Levy M. (2011) Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission. International Journal for Parasitology 41 : 591–594.
DOI: 10.1016/j.ijpara.2011.02.001
Schwarz A., Medrano-Mercado N., Billingsley P., Schaub G., Sternberg J. (2010) IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines. International Journal for Parasitology 40 : 1295–1302.
DOI: 10.1016/j.ijpara.2010.03.013

KONTAKT

Biologické centrum AV ČR, v.v.i.
Parazitologický ústav
Branišovská 1160/31
370 05 České Budějovice

NAJÍT PRACOVNÍKA