Trends in Parasitology: Bensaoud et al. 2019
Systems biology approaches, especially in the big data era, have revolutionized modern parasitology. Of the many different molecules participating in parasite–host interactions, noncoding RNAs (ncRNAs) are now known to be (i) transmitted by the vector to possibly modulate vertebrate host responses and favor vector survival and (ii) regulated in the host by parasites to favor parasite survival. Here we provide an overview of the involvement of ncRNAs in the parasite–vector–host triad and their effect on host homeostasis based on recent advances and accumulating knowledge about the role of endogenous vertebrate noncoding RNAs in vertebrate host physiology.
Highlights:
- ncRNAs participate at every stage of the parasite–vector–host interaction, subverting vertebrate host responses to vectors and host responses to parasites.
- Extracellular vesicles are important ncRNA transporters that contain several ncRNA species, including some with unknown functions, such as transfer RNAs.
- Parasite and vector ncRNAs subvert fundamental cellular processes involved in other disease, such as cancer, so may provide important leads for future therapeutic development.
Bensaoud C., Hackenberg M., Kotsyfakis M. 2019: Noncoding RNAs in Parasite-Vector-Host Interactions. Trends in Parasitology 35: 715–724. [IF=8.020]
https://www.sciencedirect.com/science/article/pii/S1471492219301631#!
