Laboratory of Enzymology of Ticks and Tick-borne Pathogens (Daniel Sojka)
Welcome to the Laboratory of Enzymology of Ticks and Tick-borne Pathogens (LETTP).
Our research seeks to uncover the molecular mechanisms that shape the biology of ticks and tick-borne pathogens and to translate these discoveries into innovative approaches for preventing and controlling tick-borne diseases.
We investigate interactions among ticks, pathogens, and vertebrate hosts through an interdisciplinary approach combining vector biology, molecular parasitology, biochemistry, functional genomics, proteomics, structural biology, and translational research. Particular attention is given to enzymes and regulatory pathways that govern tick physiology, pathogen survival and transmission, and host–vector–pathogen interactions.
By examining biological processes across the entire host–vector–pathogen interface, we aim to reveal fundamental principles of disease transmission and identify new targets for therapeutics, diagnostics, vaccines, and vector-control strategies within a One Health framework.
Our Research Areas
Tick-Borne Pathogens
We investigate the biology of tick-borne pathogens, including Babesia parasites and Borrelia bacteria, which cause babesiosis and Lyme disease, respectively. Our work focuses on host-cell invasion, nutrient acquisition, intracellular survival, and transmission by tick vectors.
Tick Biology and Vector Competence
We investigate the molecular and physiological mechanisms that enable ticks to feed, digest blood, reproduce, withstand prolonged starvation, and transmit pathogens. This knowledge supports the development of new approaches to reduce vector competence.
Enzymes and Molecular Regulation
We study how enzymes and signaling pathways, particularly proteases, kinases, and other regulatory proteins, control development and host–vector–pathogen interactions. These molecular systems represent promising targets for therapeutic and vector-control interventions.
Translational Research and Innovation
We connect fundamental research with applied approaches to identify new targets for therapeutics, vaccines, diagnostics, and vector control. Through collaborations with academic and industrial partners, we work to translate laboratory discoveries into practical solutions.
