Laboratory of Molecular Ecology of Vectors and Pathogens

Mission Statement: Vector-borne diseases particularly those caused by tick-transmitted pathogens including spirochetes are damaging for animal and human health. The laboratory is primarily focused on two research prerogatives, an understanding of the biological drivers associated with vector competence of the tick and pathogen variation at the species and strain level. Our goal is at adapting and harnessing molecular, biochemical and bioinformatic tools that will help us understand such differences in aspects associated with tick physiology, pathogen phenotypes and host susceptibility.  We want to collaborate with important stakeholders in the public/private sector and to utilize our data for diagnostics, treatment or prediction of the future spread of ticks/diseases. 

Selected publications:
Strnad M., Oh Y.J., Vancová M., Hain L., Salo J., Grubhoffer L., Nebesářová J., Hytönen J., Hinterdorfer P., Rego R. O. M. (2021) Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix Communications Biology 4: 268 .
DOI: 10.1038/s42003-021-01783-1
Genné D., Rossel M., Sarr A., Battilotti F., Rais O., Rego R. O. M., Voordouw M.J. (2021) Competition between strains of Borrelia afzelii in the host tissues and consequences for transmission to ticks The ISME Journal 2021: 2021.
DOI: 10.1038/s41396-021-00939-5
Černý J., Lynn G., Hrnková J., Golovchenko M., Rudenko N., Grubhoffer L. (2020) Management Options forIxodes ricinus-AssociatedPathogens: A Review of Prevention Strategies International Journal of Environmental Researchand Public Health 17: 1830.
DOI: 10.3390/ijerph17061830
Strnad M., Rego R. O. M. (2020) The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe Microbiology 166: 428–435.
DOI: 10.1099/mic.0.000899
Rego R. O. M., Trentelman J.J., Anguita J., Nijhof A., Sprong H., Klempa B., Hajdušek O., Tomás-Corázar J., Azagi T., Strnad M., Knorr S. , Šíma R., Jalovecká M., Havlíková S., Ličková M., Sláviková M., Kopáček P., Grubhoffer L., Hovius J. (2019) Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission Parasites & Vectors 12: 229.
DOI: 10.1186/s13071-019-3468-x

All publications (210)

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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