Mgr. Pavel Flegontov, Ph.D.

Job Position: Research Scientist - Laboratory of Molecular Biology of Protists , Research Scientist - Laboratory of Molecular Biology of Protists

Contact details

Phone: +420 387775439


Mitoproteome of Trypanosoma brucei is now catalogued. But a lot of mitochondrial proteins have completely unknown or poorly defined functions. Some of those obscure proteins appear to be conserved in eukaryotes. We focus on a group of about a dozen conserved proteins, and by making RNAi knockdowns in T. brucei try to get an idea of their functions.

Total found: 28 records
Flegontova O., Flegontov P., Malviya S., Poulain J., de Vargas C., Bowler C., Lukeš J., Horák A. (2018) Neobodonids are dominant kinetoplastids in the global ocean Environmental Microbiology 20 : 878-889.
DOI: 10.1111/1462-2920.14034

Documents to download:
Flegontova_et.al_2018 (pdf)
Gerasimov E.S., Gasparyan A.A., Kaurov I., Tichý B., Logacheva M., Kolesnikov A., Lukeš J., Yurchenko V., Zimmer S., Flegontov P. (2018) Trypanosomatid mitochondrial RNA editing: dramatically complex transcript repertoires revealed with a dedicated mapping tool Nucleic Acids Research 46 : 765-781.
DOI: 10.1093/nar/gkx1202

Documents to download:
Gerasimov et al. 2018 (pdf)
Kutanan W., Kampuansai J., Changmai P., Flegontov P., Schröder R., Macholdt E., Hübner A. , Kangwanpong D., Stoneking M. (2018) Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand Scientific Reports 8 : 1536.
DOI: 10.1038/s41598-018-20020-0
Lipson M., Cheronet O., Mallick S., Rohland N., Oxengam M., Pietrusewsky M., Pryce T.O., Willis A., Matsumura H., Buckey H., Domett K., Nguyen G.H., Trinh H.H., Kyaw A.A., Win T.T., Pradier B., Broomandkhoshbacht N., Candilio F., Changmai P., Fernandes D., Ferry M., Gamarra B., Harney E., Kampuansai J., Kutanan W., Michel M., Novak M., Oppenheimer J., Sirak K., Stewardson K., Zhang Z., Flegontov P., Pinhasi R., Reich D. (2018) Ancient genomes document multiple waves of migration in Southeast Asian prehistory Science 361 : 92–95.
DOI: 10.1126/science.aat3188
Ishemgulova A., Butenko A., Kortišová L., Boucinha C., Grybchuk-Ieremenko A., Morelli K., Tesařová M., Kraeva N., Grybchuk D., Pánek T., Flegontov P., Lukeš J., Votýpka J., Pavan M.G., Opperdoes F., Spodareva V., D'avila-Levy C., Kostygov A., Yurchenko V. (2017) Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila PLoS ONE 12 : e0174165.
DOI: 10.1371/journal.pone.0174165

Documents to download:
Ishemgulova et al. 2017 PLoS ONE (pdf)
Kılınç G.M., Koptekin D., Atakuman Ç., Sümer A.P., Dönertaş H.M., Yaka R., Bilgin C.C., Büyükkarakaya A.M., Baird D., Altınışık E., Flegontov P., Götherström A., Togan I., Somel M. (2017) Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean Proceedings Of The Royal Society B-Biological Sciences 284 : 20172064.
DOI: 10.1098/rspb.2017.2064
Kostygov A. , Butenko A., Nenarokova A., Tashyreva D., Flegontov P., Lukeš J., Yurchenko V. (2017) Genome of Ca. Pandoraea novymonadis, an Endosymbiotic Bacterium of the Trypanosomatid Novymonas esmeraldas Frontiers in Microbiology 8 : 1940.
DOI: 10.3389/fmicb.2017.01940

Documents to download:
Kostygov et al. 2017 FiM (pdf)
Skalický T., Dobáková E., Wheeler R.J., Tesařová M., Flegontov P., Jirsová D., Votýpka J., Yurchenko V., Ayala F., Lukeš J. (2017) Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid Proceedings of the National Academy of Sciences of the United States of America 114 : 11757-11762.
DOI: 10.1073/pnas.1712311114

Documents to download:
Skalicky et al. 2017 PNAS (pdf)
Tanifuji G., Cenci U., Moog D., Dean S., Nakayama T., David V., Fiala I., Curtis B., Sibbald S.J., Onodera N., Colp M., Flegontov P., Johnson-MacKinnon J., McPhee M., Inagaki Y., Hashimoto T., Kelly S., Gull K., Lukeš J., Archibald J. (2017) Genome sequencing reveals metabolic and cellular interdependence in an amoebakinetoplastid symbiosis Scientific Reports 7 : 11688.
DOI: 10.1038/s41598-017-11866-x

Documents to download:
Tanifuji et al. 2017 SR (pdf)
Flegontov P., Butenko A., Firsov S., Kraeva N., Eliáš M., Field M., Filatov D., Flegontova O., Gerasimov E.S., Hlaváčová J., Jackson A., Ishemgulova A., Kelly S., Kostygov A., Logacheva M., Maslov D., Opperdoes F., O’Reilly A., Sádlová J., Ševčíková T., Venkatesh D., Vlček Č., Volf P., Votýpka J., Záhonová K., Yurchenko V., Lukeš J. (2016) Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania Scientific Reports 6 : 23704.
DOI: 10.1038/srep23704

Documents to download:
Flegontov et al. 2016 SR6:23704 (pdf)
Flegontov P., Changmai P., Zidkova A., Logacheva M., Logacheva M., Flegontova O., Nikolsky Y., Starostin G., Stepanova V., Travinsky I., Tříska M., Tříska P., Tatarinova T. (2016) Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry Scientific Reports 6 : 20768.
DOI: 10.1038/srep20768

Documents to download:
Flegontov et al. 2016 Scientific Reports (pdf)
Flegontov P., Kassian A., Thomas M., Fedchenko V., Changmai P., Starostin G. (2016) Pitfalls of the Geographic Population Structure (GPS) Approach Applied to Human Genetic History: A Case Study of Ashkenazi Jews Genome Biology and Evolution 8 : 2259-2265.
DOI: 10.1093/gbe/evw162

Documents to download:
Flegontov et al. 2016 GBE (pdf)
Flegontova O., Flegontov P., Malviya S., Audic S., Wincker P., de Vargas C., Bowler C., Lukeš J., Horák A. (2016) Extreme diversity of diplonemid eukaryotes in the ocean Current Biology 26 : 3060-3065.
DOI: 10.1016/j.cub.2016.09.031

Documents to download:
Flegontova et al. 2016 CB (pdf)
Opperdoes F., Butenko A., Flegontov P., Yurchenko V., Lukeš J. (2016) Comparative metabolism of free-living Bodo saltans and parasitic trypanosomatids Journal of eukaryotic microbiology 63 : 657-678.
DOI: 10.1111/jeu.12315

Documents to download:
Opperdoes et al. 2016 JEM (pdf)
David V., Flegontov P., Gerasimov E.S., Tanifuji G., Hashimi H., Logacheva M., Maruyama S., Onodera N., Gray M., Archibald J., Lukeš J. (2015) Gene loss and error-prone RNA editing in the mitochondrion of Perkinsela, an endosymbiotic kinetoplastid mBio 6 : e01498-15.
DOI: 10.1128/mBio.01498-15

Documents to download:
David et al 2015 mBio (pdf)
Dobáková E., Flegontov P., Skalický T., Lukeš J. (2015) Unexpectedly streamlined mitochondrial genome of the euglenozoan Genome Biology and Evolution 7 : 3358-3367.
DOI: 10.1093/gbe/evv229

Documents to download:
Dobakova et al. 2015 GBE (pdf)
Flegontov P., Janouškovec J., Lai H., Jirků M., Hajdušková E., Tomčala A., Otto T.D., Keeling P., Pain A., Oborník M., Lukeš J. (2015) Divergent Mitochondrial Respiratory Chains in Phototrophic Relatives of Apicomplexan Parasites. Molecular Biology and Evolution 32 : 1115-1131.
DOI: 10.1093/molbev/msv021

Documents to download:
Flegontov et al. 2015 MBE (pdf)
Kraeva N., Butenko A., Hlaváčová J., Kostygov A., Myšková J., Grybchuk D., Leštinová T., Votýpka J., Volf P., Opperdoes F., Flegontov P., Lukeš J., Yurchenko V. (2015) Leptomonas seymouri: Adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani PLoS Pathogens 11 : e1005127.
DOI: 10.1371/journal.ppat.1005127

Documents to download:
Kraeva_et_al_PLOSPathogens_2015 (pdf)
Woo Y., Ansari H., Otto T.D., Klinger C., Kolísko M., Saxena A., Shanmugam D., Tayyrov A., Veluchamy A., Ali S., Bernal A., Del C., Cihlář J., Flegontov P., Gornik S., Hajdušková E., Horák A., Janouškovec J., Katris N., Mast F., Miranda-Saavedra D., Mourier T., Naeem R., Nair M., Panigrahi A., Rawlings N., Regelado E., Ramaprasad A., Samad N., Tomčala A., Wilkes J., Neafsey D., Doerig C., Bowler C., Keeling P., Roos D., Dacks J., Templeton T., Waller R., Lukeš J., Oborník M., Pain A. (2015) "Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites " eLife 4 : e06974.
DOI: 10.7554/eLife.06974

Documents to download:
Woo_et_al_eLife_2015 (pdf)
Porcel B., Denoeud F., Opperdoes F., Noel B., Madoui M., Hammarton T., Field M., Da Silva C., Couloux A., Poulain J., Katinka M., Jabbari K., Aury J., Campbell D., Cintron R., Dickens N., Docampo R., Sturm N., Koumandou V., Fabre S., Flegontov P., Lukeš J., Michaeli S., Mottram J., Szoor B., Zilberstein D., Bringaud F., Wincker P., Dollet M. (2014) The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants PLOS Genetics 10 : e1004007.
DOI: 10.1371/journal.pgen.1004007

Documents to download:
Porcel-PG-2014 (pdf)

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Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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