Interspecies variation in hominid gut microbiota controls host gene regulation
Highlights • Gut microbiota from humans, chimpanzees, gorillas, and orangutans regulate host genes • Most host genes respond to all hominid microbiomes in the same way • Some host genes respond only to microbiomes from a specific hominid species • Genes with such species-specific response are linked to human intestinal diseases
The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific host species. Such genes are associated with intestinal diseases in humans, including inflammatory bowel disease and Crohn’s disease. Last, we find that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids.
Muehlbauer A.L., Richards A.L., Alazizi A., Burns M.B., Gomez A., Clayton J.B., Petrželková K., Cascardo C., Resztak J., Wen X., Pique-Regi R., Luca F., Blekhman R. 2021: Interspecies variation in hominid gut microbiota controls host gene regulation. Cell Reports 37: 110057. [IF=9.423] DOI: 10.1016/j.celrep.2021.110057