Michalis Kotsyfakis, PhD.

Kotsyfakis

Vedoucí , Laboratoř genomiky a proteomiky vektorů

Kontakt

telefon: +420 387 775 492

e-mail: kotsyfakis@paru.cas.cz

místnost: 618

Výuka

The Human Plasma Proteome

Přírodovědecká fakulta Jihočeské univerzity

Současné publikace

více publikací

Odborný životopis

09/2009 – dodnes: Vedoucí laboratoře, Laboratoř genomiky a proteomiky vektorů Parazitologický ústav, Biologické centrum AV ČR, Česká republika.
03/2005 – 08/2009: Postgraduální student, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA.
Mentor: Professor J. M. C. Ribeiro
12/2004 – 02/2005: Postgraduální student, Laboratory of Insect Molecular Genetics, Institute of Molecular Biology and Biotechnology, FORTH, Řecko.
Mentor: Professor C. Louis

Vybrané prezentace na mezinárodních konferencích (za poslední 4 roky)

  • German Society for Parasitology Annual Meeting, 16.–20. březen 2010, Düsseldorf, Německo (biochemická session).
  • Vědecké semináře a) the Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, USA, b) Technische Universität Dresden, Drážďany, Německo, listopad 2009 (zvaná přednáška).
  • Vědecké semináře a) Parazitologický ústav, Akademie věd ČR, České Budějovice, Česká republika, b) the Department of Molecular Biology and Genetics, Alexandroupolis, Řecko, c) the Institute of Biology, National Center for Scientific Research “DEMOKRITOS”, Athens, Řecko, březen 2009 (zvaná přednáška).
  • VI International Conference on Ticks and Tick-borne Pathogens, 21.–26. září 2008, Buenos Aires, Argentina.
  • Vědecké semináře a) the Biology Department of the University of Crete, Heraklion, Řecko, b) the Biology department of the University of Cyprus, Nicosia, Kypr, c) the Medical School of the University of Thessaly, Larissa, Řecko, květen 2008 (zvaná přednáška).
  • 3rd International Meeting on Molecular and Population Biology of Mosquitoes and Other Disease Vectors, 13.–20. červen 2007, Kolymbari, Řecko.
  • 10th International Union of Biochemistry and Molecular Biology/SBBq meeting, 21.–25. května 2007, Salvador, Brazílie (zvaná přednáška).

Publikace v mezinárodních časopisech

  1. Spanos L, Koutroumbas G, Kotsyfakis M, Louis C (2000). The mitochondrial genome of the Mediterranean fruit fly, Ceratitis capitata. Insect Mol Biol. 9(4), 139-144.
  2. Kotsyfakis M, Ehret-Sabatier L, Siden-Kiamos I, Mendoza J, Sinden RE, Louis C (2005). Plasmodium berghei ookinetes bind to Anopheles gambiae and Drosophila melanogaster annexins. Mol Microbiol. 57(1), 171-9.
  3. Kotsyfakis M, Vontas J, Siden-Kiamos I, Louis C (2005). The annexin gene family in the malaria mosquito Anopheles gambiae. Insect Mol Biol. 14(5), 555-562.
  4. Kotsyfakis M, Sá-Nunes A, Francischetti IMB, Mather TN, Andersen JF and Ribeiro JMC (2006). Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis. J Biol Chem. 281(36), 26298-26307.
  5. Kotsyfakis M, Karim S, Andersen JF, Mather TN and Ribeiro JMC (2007). Selective cysteine protease inhibition contributes to blood feeding success of the tick Ixodes scapularis J Biol Chem. 282(5), 29256-29263.
  6. Francischetti IMB, Meng Z, Mans BJ, Gudderra N, Hall M, Veenstra TD, Pham VM, Kotsyfakis M, Ribeiro JMC (2008). An insight into the salivary transcriptome and proteome of the soft tick and vector of epizootic bovine abortion, Ornithodoros coriaceus. J Proteomics. 71(5):493-512.
  7. Kotsyfakis M*, Anderson JM, Andersen JF, Calvo E, Francischetti IMB, Mather TN, Valenzuela JG, and Ribeiro JMC (2008). Immunity against a "Silent" Salivary Antigen of the Lyme Vector Ixodes scapularis Impairs Its Ability to Feed, Cutting Edge Article J Immunol. 181(8): 5209-5212.
  8. Sá-Nunes ?, Bafica ?, Antonelli LRV, Choi EY, Francischetti ???, Andersen JF, Shi GP, Chavakis T, Ribeiro JMC, Kotsyfakis M* (2009). The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity J Immunol. 182(12): 7422-7429.
  9. Francischetti IMB, Kotsyfakis M, Andersen JF, Lukszo J (2010). Cyr61/CCN1 Displays High-Affinity Binding to the Somatomedin B 1–44 Domain of Vitronectin PLoS ONE 5(2): e9356.
  10. Calvo E, Sanchez-Vargas I, Kotsyfakis M, Favreau AJ, Barbian KD, Pham VM, Olson KE, Ribeiro JM (2010). The salivary gland transcriptome of the eastern tree hole mosquito, Ochlerotatus triseriatus. J Med Entomol. 47(3):376-386.
  11. Salat J, Paesen GC, Rezacova P, Kotsyfakis M, Kovarova Z, Sanda M, Majtan J, Grunclova L, Horka H, Andersen JF, Brynda J, Horn M, Nunn MA, Kopacek P, Kopecky J, Mares M. (2010). Crystal structure and functional characterisation of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata. Biochem J. 429(1):103-112.
  12. Kotsyfakis M, Horka H, Salat J, Andersen JF. (2010). The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model. Mol Microbiol. 77(2):456-470
  13. Chmelar J, Francischetti IMB. and Kotsyfakis M, 2010: Salivary Protease Inhibitors with Non Anti-Hemostatic Functions, in Toxins and Hemostasis: From Bench to Bedside. Kini R.M. et al editors, (Springer Science Media B.V), 13pp
  14. Calvo E, Mizurini DM, Sá-Nunes A, Ribeiro JMC, Andersen JF, Mans BJ, Monteiro RQ, Kotsyfakis M, Francischetti IMB (2011). Alboserpin, a Factor Xa inhibitor from the mosquito vector of Yellow Fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity. J Biol Chem. 2011 Jun 14. [Epub ahead of print] [I.F. = 5.3]
  15. Tsujimoto H, Kotsyfakis M, Francischetti IM, Eum JH, Strand MR, Champagne DE (2011). Functional characterization of a salivary anti-coagulant Kunitz protein from the black fly, Simulium vittatum PLoS One In Press. [I.F. = 4.4]
  16. Horka H, Staudt V, Klein M, Taube C, Reuter S, Dehzad N, Andersen JF, Kopecky J, Schild H, Kotsyfakis M, Stassen M, Bopp T, Schmitt E. The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine interleukin-9 and is effective in the prevention of experimental asthma Submitted revision in J Immunol.
  17. Chen G, Severo MS, Sohail M, Sakhon OS,  Ulland TK, Andersen JF, Herron MJ, Felshein RF, Wikel SK, Munderloh UG, Sutterwala FS, Kotsyfakis M, Pedra JHF. Anaplasma phagocytophilum-mediated inflammation is inhibited by both microbial and vector-derived molecules Submitted in Cell Microbiol.
  18. Francischetti IMB, Oliveira CJ, Ostera G, Yager SB, Debierre-Grokiego F, Carregaro V, Jaramillo-Gutierrez G, Humme J, Jiang L, Moretz S, Nardone G, Ribeiro JM, Long CA, Pierce S, Schwarz RT, Seydel KB, Iacobelli M, Ackerman HC, Gomes R, Wang X, Monteiro RQ, Kotsyfakis M, Sá-Nunes A, Waisberg M. Defibrotide interferes with several steps of the coagulation inflammation cycle and exhibits therapeutic potential to treat severe malaria Submitted in Arterioscler Thromb Vasc Biol.
     

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