Date: 21.05.2019

The trickster microbes that are shaking up the tree of life

Mysterious groups of archaea — named after Loki and other Norse myths — are stirring debate about the origin of complex creatures, including humans.

Every mythology needs a good trickster, and there are few better than the Norse god Loki. He stirs trouble and insults other gods. He is elusive, anarchic and ambiguous. He is, in other words, the perfect namesake for a group of microbes — the Lokiarchaeota — that is rewriting a fundamental story about life’s early roots.

These unruly microbes belong to a category of single-celled organisms called archaea, which resemble bacteria under a microscope but are as distinct from them in some respects as humans are. The Lokis, as they are sometimes known, were discovered by sequencing DNA from sea-floor muck collected near Greenland1. Together with some related microbes, they are prodding biologists to reconsider one of the greatest events in the history of life on Earth — the appearance of the eukaryotes, the group of organisms that includes all plants, animals, fungi and more.

The discovery of archaea in the late 1970s led scientists to propose that the tree of life diverged long ago into three main trunks, or ‘domains’. One trunk gave rise to modern bacteria; one to archaea. And the third produced eukaryotes. But debates soon erupted over the structure of these trunks. A leading ‘three-domain’ model held that archaea and eukaryotes diverged from a common ancestor. But a two-domain scenario suggested that eukaryotes diverged directly from a subgroup of archaea.

The arguments, although heated at times, eventually stagnated, says microbiologist Phil Hugenholtz at the University of Queensland in Brisbane, Australia. Then the Lokis and their relatives blew in like “a breath of fresh air”, he says, and revived the case for a two-domain tree.

These newly discovered archaea have genes that are considered hallmarks of eukaryotes. And deep analysis of the organisms’ DNA suggests that modern eukaryotes belong to the same archaeal group. If that’s the case, essentially all complex life — everything from green algae to blue whales — originally came from archaea.

But many scientists remain unconvinced. Evolutionary tree building is messy, contentious work. And no one has yet published evidence to show that these organisms can be grown in the lab, which makes them difficult to study. The debate is still rancorous. Stalwarts on both sides are “very hostile to each other, and 100% believe there’s nothing correct in the other camp”, Hugenholtz says. Some decline to voice an opinion, for fear of offending senior colleagues.

What’s at stake is a deeper understanding of the biological leap that produced eukaryotes: “The biggest thing that happened since the origin of life,” according to evolutionary biologist Patrick Keeling at the University of British Columbia in Vancouver, Canada. Where they came from “is one of the most fundamental questions in understanding the nature of biological complexity”, he says. To answer that question, “we need to resolve who’s related to who”.

The rest of the article is here. 

Watson T. 2019: The trickster microbes that are shaking up the tree of life. Nature 569: 322–324. 




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