RNDr. Luděk Eyer, Ph.D.

Funkce: Vědecký pracovník - Laboratoř arbovirologie

Kontaktní údaje

Telefon: +420 533331911
E-mail: eyer@vri.cz
Místnost: 316

Publikace
Celkem nalezeno: 26 záznamů
Dejmek M., Konkolová E., Eyer L., Straková P., Svoboda P., Šála M., Krejčová K., Růžek D., Boura E., Nencka R. (2021) Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication Viruses-Basel 8 : 1585.
DOI: 10.3390/v13081585
Eyer L., Svoboda P., Balvan J., Vičar T., Raudenská M., Štefánik M., Haviernik J., Huvarová I., Straková P., Rudolf I., Hubálek Z., Seley-Radtke K., De Clercq E., Růžek D. (2021) Broad-spectrum antiviral activity of 3′-Deoxy-3′-fluoroadenosine against emerging flaviviruses Antimicrobial Agents and Chemotherapy 65 : e01522-20.
DOI: 10.1128/AAC.01522-20
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185 : 104968.
DOI: 10.1016/j.antiviral.2020.104968
Milisavljevic N., Konkolová E., Kozák J., Hodek J., Veselovská L., Čížek K., Pohl R., Eyer L., Svoboda P., Růžek D., Weber J., Nencka R., Boura E., Hocek M. (2021) Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS Infectious Diseases 76 : 471–478.
DOI: 10.1021/acsinfecdis.0c00829
Štefánik M., Straková P., Haviernik J., Miller A., Růžek D., Eyer L. (2021) Antiviral activity of vacuolar atpase blocker diphyllin against sars-cov-2 Microorganisms 9 : 471.
DOI: 10.3390/microorganisms9030471
Gejji V. , Svoboda P., Štefánik M., Wang H., Salát J., Eyer L., Růžek D., Fernando S. (2020) An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus(Article) Virology 546 : 13–19.
DOI: 10.1016/j.virol.2020.03.006
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2020) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: a new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185 : 104968.
DOI: 10.1016/j.antiviral.2020.104968
Procházková E. , Hřebabecký H., Dejmek M., Šála M., Šmídková M., Tloušťová E., Zborníková E., Eyer L., Růžek D., Nencka R. (2020) Could 5 '-N and S ProTide analogues work as prodrugs of antiviral agents? Bioorganic&MedicinalChemistryLetters 30 : 126897.
DOI: 10.1016/j.bmcl.2019.126897
Salát J., Mikulášek K., Larralde O., Pokorná Formanová P., Chrdle A., Haviernik J., Elsterová J., Teislerová D., Palus M., Eyer L., Zdráhal Z., Petrik J., Růžek D. (2020) Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and may Elicit NS1-Specific Antibody Responses in Vaccinated Individuals. Vaccines 8 : 81.
DOI: 10.3390/vaccines8010081
Štefánik M., Valdés J. J., Ezebuo F.C., Haviernik J., Uzochukwu I.C., Fojtikova M., Salát J., Eyer L., Růžek D. (2020) FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells Microorganisms 8 : 599.
DOI: 10.3390/microorganisms8040599
Eyer L., Fojtikova M., Nencka R., Rudolf I., Hubálek Z., Růžek D. (2019) Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection Antimicrobial Agents and Chemotherapy 63 : e02093-18.
DOI: 10.1128/AAC.02093-18
Eyer L., Nougairède A., Uhlířová M., Driouich J.S., Zouharova D., Valdés J. J., Haviernik J., Gould E., De Clercq E., de Lamballerie X., Růžek D. (2019) An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. Journal of Virology 93 : pii: e00367-19.
DOI: 10.1128/JVI.00367-19
Krol E., Wandzik I., Brzuska G., Eyer L., Růžek D., Szewczyk B. (2019) Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus Molecules 24 : 1129.
DOI: 10.3390/molecules24061129
Růžek D., Avšič Županc T., Borde J., Chrdle A., Eyer L., Karganova G. , Kholodilov I., Knap N., Kozlovskya L., Matveev A., Miller A., Osoldkin D.I., Överby A.K., Titukonova N. , Tkachev S., Zajkowska J. (2019) Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines Antiviral Research 164 : 23–51.
DOI: 10.1016/j.antiviral.2019.01.014
Eyer L., Nencka R., De Clercq E., Seley-Radtke K., Růžek D. (2018) Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses. vAntiviral Chemistry and Chemotherapy 26 : 1-28.
DOI: 10.1177/2040206618761299
Haviernik J., Štefánik M., Fojtikova M., Kali S., Noël T., Rudolf I., Hubálek Z., Růžek D., Eyer L. (2018) Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses. Viruses 10 : 184.
DOI: 10.3390/v10040184
Salát J., Formanová P., Huňady M., Eyer L., Palus M., Růžek D. (2018) Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use Vaccine 36 : 7257–7261.
DOI: 10.1016/j.vaccine.2018.10.034
Štefánik M., Formanová P., Bílý T., Vancová M., Eyer L., Palus M., Salát J., Braconi C. T. , Zanotto De A. P., Gould E., Růžek D. (2018) Characterisation of Zika virus infection in primary human astrocytes. BMC Neuroscience BMC Neuroscience 18 : 1136.
DOI: 10.1186/s12868-018-0407-2
Eyer L., Kondo H., Zouharova D., Hirano M., Valdés J. J., Muto M., Kasti T., Kobayashi S., Haviernik J., Igarashi M., Kariwa H., Vaculovicova M., Černý J., Kizek R., Kröger A., Lienenklaus S., Dejmek M., Nencka R., Palus M., Salát J., De Clercq E., Yoshii K., Růžek D. (2017) Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness Journal of Virology 91 : e01028-17.
DOI: 10.1128/JVI.01028-17
Eyer L., Zouharova D., Širmarová J., Fojtikova M., Štefánik M., Haviernik J., Nencka R., De Clercq E., Růžek D. (2017) Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses Antiviral Research 142 : 63-67.
DOI: 10.1016/j.antiviral.2017.03.012

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