Laboratoř molekulární ekologie a evoluce

Our research is mainly focused on molecular analysis of the host-parasite co-evolution. It involves investigation of the population structure, diversity, biogeography and adaptations of the hosts and their parasites using population genetic and genomic type of data. On a deeper evolutionary scale we are also interested in the origin, evolution and relationships of parasitic and symbiotic organisms.

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Vybrané publikace:
Drábková  M., Jachníková N., Tyml T., Sehadová H., Ditrich O., Myšková E., Hypša V., Štefka J. (2019) Population co-divergence in common cuttlefish (Sepia officinalis) and its dicyemid parasite in the Mediterranean Sea. Scientific Reports 9: 14300.
DOI: 10.1038/s41598-019-50555-9
Roumbedakis K. , Drábková  M., Tyml T., di Cristo C. (2019) A Perspective Around Cephalopods and Their Parasites, and Suggestions on How to Increase Knowledge in the Field. Frontiers in Physiology 9: 1573.
DOI: 10.3389/fphys.2018.01573
Martinů J., Hypša V., Štefka J. (2018) Host specificity driving genetic structure and diversity in ectoparasite populations: co-evolutionary patterns in Apodemus mice and their lice Ecology and Evolution 8: 10008–10022.
DOI: 10.1002/ece3.4424
Vlček J., Hoeck P., Keller L., Wayhart J., Dolinová J., Štefka J. (2016) Balancing selection and genetic drift create unusual patterns of MHCIIβ variation in Galápagos mockingbirds Molecular Ecology 25: 4757-4772.
DOI: 10.1111/mec.13807
Husník F., Mccutcheon J. (2016) Repeated replacement of an intrabacterial symbiont in the tripartite nested mealybug symbiosis Proceedings of the National Academy of Sciences 113: E5416-E5424.
DOI: 10.1073/pnas.1603910113

Všechny publikace (89)

Řešené výzkumné projekty

Coevolution between Galápagos mockingbirds and their ectoparasites

Galapagos mockingbirds comprise four species of recently radiated passerines endemic to the Galapagos archipelago. Co-analysing mitochondrial and nuclear markers of mockingbirds and their ectoparasites the most likely scenario of colonisation of particular islands within the archipelago was reconstructed. Link between population size, geographical range and parasite load is being analysed using high-throughput sequencing of MHC genes and neutral multilocus markers. Obtaining knowledge of MHC gene diversity is also of conservation interest, since several species of mockingbirds are threatened or even extinct in their original area of distribution (e.g. Floreana mockingbird). 

Population genetics, demography and molecular evolution in rodents and their parasites

Adaptive and co-speciation components of host-parasite coevolution are studied in rodents and their parasites. Two rodent groups (voles and wood-mice) and their ectoparasites (lice, mites) as well as endoparasites (Eimeria) were selected as the model groups. Population structure was analysed using mitochondrial genes and selected nuclear markers. Despite observing lineages with relatively strict degree of host specificity, only limited amount of co-speciation was seen in both parasitic groups. Hence, the adaptive component of evolution seems to be the major driver defining genetic differentiation. Obtained patterns will be validated and explored in further detail using sequences of genes putatively under selection in the hosts (MHC II) and using multilocus and genomic data obtained from both counterparts.


Evolution of symbiotic bacteria associated with arthropods

We are broadly interested in intracellular symbiotic bacteria and their arthropod hosts. The main goal of our research is complex characterization of symbiotic systems in several model insect groups using microscopy, genomic, transcriptomic, and phylogenomic methods. Our main questions involve genome evolution of both the host and its symbionts, their phylogeny and populational structure, and host-symbiont-pathogen interactions. 


Biologické centrum AV ČR, v.v.i.
Parazitologický ústav
Branišovská 1160/31
370 05 České Budějovice