RNDr. Alena Panicucci Zíková, Ph.D.

Funkce: Zástupce ředitele , Vedoucí laboratoře - Laboratoř funkční biologie protist

Kontaktní údaje

Telefon: +420 387775482
E-mail: azikova@paru.cas.cz
Místnost: PARU II, 2.06

Odborný životopis

Více informací v anglické verzi.

Výuka Biochemie a molekulární biologie parazitů / Biochemistry and molecular biology of parasites
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Pokročilé metody molekulární biologie / Advanced Methods in Molecular Biology
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Molekulární biologie / Molecular Biology of Cell
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Publikace
Celkem nalezeno: 55 záznamů
Gahura O., Chauhan P., Panicucci Zíková A. (2022) Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids Trends in Parasitology 38 : 1053-1067.
DOI: 10.1016/j.pt.2022.08.010
Gahura O., Mühleip A., Hierro-Yap C., Panicucci B., Jain M., Hollaus D., Slapničková M., Panicucci Zíková A., Amunts A. (2022) An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Nature Communications 13 : 5989.
DOI: 10.1038/s41467-022-33588-z
Klejch T., Keough D., King G., Doleželová E., Česnek M., Buděšínský M., Panicucci Zíková A., Janeba Z., Guddat L., Hocková D. (2022) Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases Journal of Medicinal Chemistry 65 : 4030–4057.
DOI: 10.1021/acs.jmedchem.1c01881
Lemke C., Jílková A., Ferber D., Braune A., On A., Johe P., Panicucci Zíková A., Schirmeister T., Mareš M., Horn M., Gütschow M. (2022) Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain Chemistry-A European Journal 28 : e202201636.
DOI: 10.1002/chem.202201636
Panicucci Zíková A. (2022) Mitochondrial adaptations throughout the Trypanosoma brucei life cycle Journal of Eukaryotic Microbiology 69 : e12911.
DOI: 10.1111/jeu.12911
Štěpánek O., Čmoková A., Procházková E. , Grobárová V., Černý J., Slapničková M., Panicucci Zíková A., Kolařík M., Baszczyňski O. (2022) Piperazine-Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens ChemMedChem 17 : e202200385.
DOI: 10.1002/cmdc.202200385
Vaňková K., Doleželová E., Tloušťová E., Hocková D., Panicucci Zíková A., Janeba Z. (2022) Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase European Journal of Medicinal Chemistry 239 : 114559.
DOI: 10.1016/j.ejmech.2022.114559
Cadena L., Gahura O., Panicucci B., Panicucci Zíková A., Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere 16 : e0032721.
DOI: 10.1128/mSphere.00327-21

Dokumenty ke stažení:
Cadena_2021_mSphere (pdf)
Doleželová E., Klejch T., Špaček P., Slapničková M., Guddat L., Hocková D., Zíková A. (2021) Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro Scientific Reports 11 : 13317.
DOI: 10.1038/s41598-021-91747-6
Gahura O., Hierro-Yap C., Zíková A. (2021) Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase Parasitology 148 : 1151–1160.
DOI: 10.1017/S0031182021000202
Hierro-Yap C., Šubrtová , Gahura O., Panicucci B., Dewar C., Chinopoulos C., Schnaufer A., Zíková A. (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Journal of Biological Chemistry 296 : 100357.
DOI: 10.1016/j.jbc.2021.100357
Kalčic F., Frydrych J., Doleželová E., Slapničková M., Pachl P., Slavětínská L.P., Hocková D., Zíková A., Janeba Z. (2021) C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase European Journal of Medicinal Chemistry 225 : 113798.
DOI: 10.1016/j.ejmech.2021.113798
Nguyen V.H., Tichý M., Rožánková S., Pohl R., Doleželová E., Tloušťová E., Slapničková M., Zíková A., Hocek M. (2021) Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides Bioorganic & Medicinal Chemistry Letters 40 : 127957.
DOI: 10.1016/j.bmcl.2021.127957
Perlíková P., Krajczyk A., Doleželová E., Slapničková M., Milisavljevic N., Slavětínská L.P., Tloušt'ová E., Gurská S., Džubák P., Hajdúch M., Panicucci Zíková A., Hocek M. (2021) Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides ACS Infectious Diseases 7 : 917–926.
DOI: 10.1021/acsinfecdis.1c00062
Serricchio M., Hierro-Yap C., Schädeli D., Hamidane H.B., Hemphill A., Graumann J., Panicucci Zíková A., Bütikofer P. (2021) Depletion of cardiolipin induces major changes in energy metabolism in Trypanosoma brucei bloodstream forms Faseb Journal 35 : e21176.
DOI: 10.1096/fj.202001579RR
Tobiasson V., Gahura O., Aibara S., Baradaran R., Panicucci Zíková A., Amunts A. (2021) Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit Embo Journal e106292.
DOI: 10.1101/2020.06.28.176446
Villafraz O., Biran M., Pineda E., Plazolles N., Cahoreau E., Ornitz Oliveira Souza R., Thonnus M., Allmann S., Tetaud E., Rivière L., Silber A.M., Barrett M.P., Zíková A., Boshart M., Portais J.C., Bringaud F. (2021) Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline PLoS Pathogens 17 : 1009204.
DOI: 10.1371/journal.ppat.1009204
Aphasizheva I., Alfonzo J., Carnes J., Cruz-Reyes J., Göringer H.U., Hajduk S., Lukeš J., Madison-Antenucci S., Maslov D., Mcdermott S., Ochsenreiter T., Read L., Salavati R., Schnaufer A., Schneider A., Simpson L., Stuart K., Yurchenko V., Zhou Z.H., Panicucci Zíková A., Zhang L., Zimmer S., Aphasizhev R. (2020) Lexis and Grammar of Mitochondrial RNAProcessing in Trypanosomes Trends in Parasitology 36 : 4.
DOI: 10.1016/j.pt.2020.01.006

Dokumenty ke stažení:
Aphasizheva_2020_TrendsinParasitology (pdf)
Doleželová E., Kunzová M., Dejung M., Levin M., Panicucci B., Regnault C., Janzen C., Barrett M.P., Butter F., Panicucci Zíková A. (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei Plos Biology 18 : e3000741.
DOI: 10.1371/journal.pbio.3000741
Smith J.T., Doleželová E., Tylec B., Bard J.E., Chen R., Sun Y., Panicucci Zíková A., Read L. (2020) Developmental regulation of edited CYb and COIII mitochondrial mRNAs is achieved by distinct mechanisms in Trypanosoma brucei Nucleic Acids Research 48 : 8704–8723.
DOI: 10.1093/nar/gkaa641

Více publikací

KONTAKT

Biologické centrum AV ČR, v.v.i.
Parazitologický ústav
Branišovská 1160/31
370 05 České Budějovice

NAJÍT PRACOVNÍKA