Mgr. Václav Hönig, Ph.D.

Funkce: Vědecký pracovník - Laboratoř arbovirologie

Kontaktní údaje

Telefon: +420 387775145
E-mail: honig@paru.cas.cz
Web: gisak.vsb.cz/klistata/
Místnost: 324

Popis

Eko-epidemiologie zejména vektory přenášených zoonotických nákaz (virus klíšťové encefalitidy, hantaviry, spirochéty Lymeské boreliozy...), ekologie vektorů infekčních onemocnění, interakce patogen-vektor-hostitel na buněčné, organizmální, populační úrovni.

Odborný životopis

Education

2015: University of South Bohemia, Faculty of Science, and Academy of Sciences of the Czech Republic, Institute of Parasitology, Ph.D. (Parasitology)

2007: Masaryk University, Brno, Faculty of Biological Science, M.Sc. (General Biology – Microbiology)

2005: University of South Bohemia, Faculty of Biological Sciences, B.Sc. (Biology & Biomedical Laboratory Techniques)

Other education, courses, trainings, qualifications

- certificate of professional competence to design experiments and experimental projects under the Section 15d (3) of Act No 246/1992 Coll., on the Protection of Animals against Cruelty – experimental animal handling

- PREFEKT – Systemic complex education of R&D scientists in management and administration

Professional Experience

2016 - present Postdoctoral Scientist, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences,České Budějovice, Czech Republic & Veterinary Research Institute, Brno, Czech Republic

2011-2016 Head of R & D department, project manager, GEN-TREND, s. r. o., Czech Republic

2008-2012 Research Assistant, Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic

2009-2011 Research Assistant, University of South Bohemia, Faculty Science

Stays Abroad

2009 Laboratory of Eco-Epidemiology of Parasites, Institute of Biology, University of Neuchâtel, Switzerland

2009 Institute of Applied Statistic, Johannes Kepler University, Linz, Austria; AKTION scholarship

2009, 2010 several shorter visits, Institute of Comparative Tropical Medicine and Parasitology, Ludwig-Maximilian University, Munich

Teaching Activities

Medical Virology Course, Faculty of Science, University of South Bohemia (since 2018)
Teaching assistant in practical courses: Biochemistry, Medical virology and workshops POSTICK Spring school 2011
Consultant or supervisor of 4 bachelor (2 active), 6 master (1 active) thesis

Reviewer for scientific journals

Ticks and tick-borne Diseases Journal, International Journal of Environmental Research and Public Health, Folia Parasitologica, Epidemiology and Infection, Viruses, Eurosurveillance, Antibiotics

Research focus

ecology, eco-epidemiology and molecular epidemiology of zoonotic vector-borne and rodent-borne diseases caused by viral and bacterial agents; ecology of ticks; detection and identification of pathogens using molecular biology methods; pathogen-vector-host interactions

Specific skills and methods

molecular biology-based detection and typisation methods (PCR, qPCR, RT-PCR, SSCP, RLB, sequencing), Luminex - MagPix technology work with laboratory and wild rodents, birds, work with infectious agents – BSL2, BSL3, basic method in statistics, experience with GIS and spatial modeling, bioinformatics and web design

Participation in recent relevant research projects

Team member:

Ticks and tick borne infectious diseases in the conditions of South Bohemia and Bavaria; Ziel 3; European Development Fund of the European Union; University of South Bohemia, Faculty of Science

AKTION 53p19; Spatial mapping of ticks and tick-borne infectious diseases of the region of South Bohemia and Upper Austria; Ministry of Education, Youth, and Sports of the Czech Republic; University of South Bohemia, Faculty of Science

Innovation of a diagnostic product – enhancement of the method of detection of periodontal pathogens; The Enterprises and Innovations Operational Programme – Innovations; Ministry of Industry and Trade of the Czech Republic; GEN-TREND s. r. o.

Czech-Austrian Center for Supracellular Medical Research; INTERREG – Austria – Czech Republic; European research and development fund; Biology Centre AS CR, Institute of Parasitology

Role of urban wildlife in circulation of vector-borne zoonotic pathogens with emphasis on Anaplasma phagocytophilum; Czech Science Foundation; Biology Centre AS CR, Institute of Parasitology

Neurovascular unit cells interactions leading to the blood-brain barrier breakdown during tickborne encephalitis; Czech Science Foundation; Biology Centre AS CR, Institute of Parasitology

Molecular mechanisms of tick-borne encephalitis pathogenesis; Czech Science Foundation; Biology Centre AS CR, Institute of Parasitology

PI or Co-PI:

Development, extension and support of collections of biological material and support of their use in applied research and technology, ROZE – Strategy AV21, Biology Centre AS CR, Institute of Parasitology

Selected Publications in journals with impact factor

Total of 14 publications with IF, h-index 6, 189 citations (in Scopus).

Zubrikova D, Wittmann M, Hönig V, Svec P, Vichova B, Essbauer S, Dobler G, Grubhoffer L, Pfister K. Prevalence of tick-borne encephalitis virus and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks in Lower Bavaria and Upper Palatinate, Germany. Ticks Tick Borne Dis. 2020 Jan 15:101375.

Hönig V, Palus M, Kaspar T, Zemanova M, Majerova K, Hofmannova L, Papezik P,Sikutova S, Rettich F, Hubalek Z, Rudolf I, Votypka J, Modry D, Ruzek D. Multiple lineages of Usutu virus (Flaviviridae, Flavivirus) in blackbirds (Turdus merula) and mosquitoes (Culex pipiens, Cx. modestus) in the Czech Republic (2016-2019). Microorganisms. 2019 Nov 16;7(11). pii: E568.

Hönig V, Svec P, Marek L, Mrkvicka T, Zubrikova D, Wittmann (Vögerl) M, Masar O, Szturcova D, Ruzek D, Pfister K, Grubhoffer L. Model of risk of exposure to Lyme borreliosis and tick-borne encephalitis virus infected ticks in the border area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate). Int J Environ Res Public Health. 2019 Apr 2; 16(7): pii: E1173.

Hönig V, Carolan HE, Vavruskova Z, Massire C, Mosel MR, Crowder CD, Rounds MA, Ecker DJ, Ruzek D, Grubhoffer L, Luft BJ, Eshoo MW. Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic. FEMS Microbiol Ecol. 2017 Nov 1; 93(11).

Strnad M, Hönig V, Ruzek D, Grubhoffer L, Rego ROM. Europe-wide meta-analysis of Borrelia burgdorferi sensu lato prevalence in questing Ixodes ricinus ticks. Appl Environ Microbiol. 2017 Jul 17; 83(15): pii: e00609-17.
Hönig V, Svec P, Halas P, Vavruskova Z, Tykalova H, Kilian P, Vetiskova V, Dornakova V, Sterbova J, Simonova Z, Erhart J, Sterba J, Golovchenko M, Rudenko N, Grubhoffer L. Ticks and tick-borne pathogens in South Bohemia (Czech Republic) - Spatial variability in Ixodes ricinus abundance, Borrelia burgdorferi and tick-borne encephalitis virus prevalence. Ticks Tick-Borne Dis. 2015 Jul; 6: 559-567.
Crowder CD, Carolan HE, Rounds MA, Hönig V, Mothes B, Haag H, Nolte O, Luft BJ, Grubhoffer L, Ecker DJ, Schutzer SE, Eshoo MW. Prevalence of Borrelia miyamotoi in Ixodes ticks in Europe and the United States. Emerg Infect Dis. 2014 Oct; 20: 1678-1682.

Publikace

Celkem nalezeno: 19 záznamů
Agudelo M., Palus M., Keeffe J., Bianchini F., Svoboda P., Salát J., Peace A., Gazumyan A., Cipolla M., Kapoor T., Guidetti F., Yao K.H., Elsterová J., Teislerová D., Chrdle A., Hönig V., Oliveira T., West A.P., Lee Y.E., Rice C.M., MacDonald M.R., Bjorkman P.J., Růžek D., Robbiani D.F., Nussenzweig M.C. (2021) Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Journal of Experimental Medicine 218 : e20210236. DOI: 10.1084/jem.20210236
Beliavskaia A., Hönig V., Erhart J., Vyhlídalová T., Palus M., Černý J., Kozlova I., Růžek D., Palomar A.M., Bell-Sakyi L. (2021) Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks. Frontiers in Veterinary Science 8 : 659786. DOI: 10.3389/fvets.2021.659786
Helmová R., Hönig V., Tykalová H., Palus M., Bell-Sakyi L., Grubhoffer L. (2020) Tick-borne encephalitis virus adaptation in different host environments and existence of quasispecies Viruses 12 : 902. DOI: 10.3390/v12080902
Majerová K., Hönig V., Houda P., Papežík P. , Fonville M., Sprong H., Rudenko N., Golovchenko M., Černá Bolfíková B., Hulva P., Růžek D., Hofmannová L., Votýpka J., Modrý D. (2020) Hedgehogs, Squirrels, and Blackbirds as Sentinel Hosts for Active Surveillance of Borrelia miyamotoi and Borrelia burgdorferi Complex in Urban and Rural Environments Microorganisms 8 : 1908. DOI: 10.3390/microorganisms8121908
Zubriková D. , Wittmann M., Hönig V., Švec P., Víchová B., Essbauer S., Dobler G., Grubhoffer L., Pfister K. (2020) Prevalence of tick-borne encephalitis virus and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks in Lower Bavaria and Upper Palatinate, Germany Ticks and Tick-borne Diseases 11 : 101375. DOI: 10.1016/j.ttbdis.2020.101375
Dufková P., Širmarová J., Salát J., Hönig V., Palus M., Růžek D., Fooks A., Mansfield K.L., Tordo N., Jochmans D., Neyts J., Byron M., Koraka P., Osterhaus A.D.M.E., Asklepios consortium (2019) Mannitol treatment is not effective in therapy of rabies virus infection in mice Vaccine 37 : 4710–4714. DOI: 10.1016/j.vaccine.2017.12.028
Hönig V., Palus M., Kašpar T., Majerová K., Zemanová M., Hofmannová L., Papežík P. , Šikutová S., Rettich F., Hubálek Z., Rudolf I., Votýpka J., Modrý D., Růžek D. (2019) Multiple Lineages of Usutu Virus (Flaviviridae, Flavivirus) in Blackbirds (Turdus merula) and Mosquitoes (Culex pipiens, Cx. modestus) in the Czech Republic (2016–2019) Microorganisms 7 : 568. DOI: 10.3390/microorganisms7110568
Hönig V., Švec P., Marek L., Mrkvička T., Zubrikova D., Wittmann M., Masař O., Szturcová D., Růžek D., Pfister K., Grubhoffer L. (2019) Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate) International Journal of Environmental Research and Public Health 16 : 1173. DOI: 10.3390/ijerph16071173
Marosi A., Dufkova L., Forró B., Felde O., Erdélyi K., Širmarová J., Palus M., Hönig V., Salát J., Tikos R., Gyuranecz M., Růžek D., Byron M., Koraka P., Osterhaus A.D.M.E., Bakonyi T. (2019) Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin Vaccine 37 : 4724–4735. DOI: 10.1016/j.vaccine.2018.05.066
Pokorná Formanová P., Palus M., Salát J., Hönig V., Štefánik M., Svoboda P., Růžek D. (2019) Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection Journal of neuroinflammation 16 : 205. DOI: 10.1186/s12974-019-1596-z
Švec P., Hönig V., Zubrikova D., Wittmann M., Pfister K., Grubhoffer L. (2019) The use of multi-criteria evaluation for the selection of study plots for monitoring of I. ricinus ticks - Example from Central Europe Ticks and Tick-borne Diseases 10 : 905–910. DOI: 10.1016/j.ttbdis.2019.04.014
Širmarová J., Salát J., Palus M., Hönig V., Langhansová H., Holbrook M., Růžek D. (2018) Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells Emerging Microbes & Infections 7 : 175. DOI: 10.1038/s41426-018-0177-z
Hönig V., Carolan H., Vavrušková Z., Massire C., Mosel M.R., Crowder C., Rounds M., Ecker D., Růžek D., Grubhoffer L., Luft B., Eshoo M. (2017) Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic FEMS Microbiology Ecology 93 : fix129. DOI: 10.1093/femsec/fix129
Strnad M., Hönig V., Růžek D., Grubhoffer L., Rego R. O. M. (2017) Europe-wide meta-analysis of Borrelia burgdorferi sensu lato prevalence in questing Ixodes ricinus ticks Applied and Environmental Microbiology 83 : e00609-17. DOI: 10.1128/AEM.00609-17
Hönig V., Švec P., Halas P., Vavrušková Z., Šťastná H., Kilian P., Vrtišková V., Dorňáková V., Dupejová J., Simonová Z., Mondeková H., Erhart J., Štěrba J., Golovchenko M., Grubhoffer L., Rudenko N. (2015) Ticks and tick-borne pathogens in South Bohemia (Czech Republic) - spatial variability in Ixodes ricinus abundance, Borrelia burgdorferi and tick-borne encephalitis virus prevalence Ticks and Tick-borne diseases 6 : 559-567. DOI: 10.1016/j.ttbdis.2015.04.010
Crowder Chris D., Carolan Heather E., Rounds Megan A., Hönig V., Mothes B., Haag H., Nolte O., Luft Ben J., Grubhoffer L., Ecker David J., Schutzer Steven E., Eshoo Mark W. (2014) Prevalence of Borrelia miyamotoi in Ixodes ticks in Europe and the United States. Emerging Infectious Diseases 20 : 1678-1682. DOI: 10.3201/eid2010.131583
Rudenko N., Golovchenko M., Hönig V., Mallátová N., Krbková L., Mikulášek P., Fedorova N., Belfiore N., Grubhoffer L., Lane R., Oliver J. (2013) Detection of Borrelia burgdorferi Sensu Stricto ospC Alleles Associated with Human Lyme Borreliosis Worldwide in Non-Human-Biting Tick Ixodes affinis and Rodent Hosts in Southeastern United States Applied and Enviromental Microbiology 79 : 1444-1453. DOI: 10.1128/AEM.02749-12
Schwarz A., Hönig V., Vavrušková Z., Grubhoffer L., Balczun C., Albring A., Schaub G. (2012) Abundance of Ixodes ricinus and prevalence of Borrelia burgdorferi s.l. in the nature reserve Siebengebirge, Germany, in comparison to three ormer studies from 1978 onwards. Parasites & vectors 5 : 268. DOI: 10.1186/1756-3305-5-268
Daniel M., Materna J., Hönig V., Metelka L., Danielová V., Harčarik J., Kliegrová S., Grubhoffer L. (2009) Vertical distribution of the tick Ixodes ricinus and tick-borne pathogens in the northern Moravian mountains correlated with climate warming (Jeseníky Mts., Czech Republic). Cent Eur J Public Health 17 : 139-145.

Mgr. Václav Hönig, Ph.D.

KONTAKT

NAJÍT PRACOVNÍKA