Mgr. Jiří Holoubek

Job Position: PhD student - Laboratory of Arbovirology

Contact details

Phone: +420 38 777 5463
E-mail: jiri.holoubek@paru.cas.cz
Room: 324

Publications
Total found: 12 records
Beránková M., Holoubek J., Hönig V., Matúšová Z., Palus M., Salát J., Krayem I., Vojtíšková J. , Svoboda P., Prančlová V., Valihrach L., Demant P., Lipoldová M., Růžek D. (2025) Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain Journal of Neuroinflammation 22 : 22.
DOI: 10.1186/s12974-025-03354-1
Beránková M., Leoni S., Holoubek J., Haviernik J., Salát J., Grandgirard D., Leib S.L., Růžek D. (2025) Three-dimensional mapping of tick-borne encephalitis virus distribution in the mouse brain using a newly engineered TurboGFP reporter virus. Emerging Microbes & Infections 14 : 2542246.
DOI: 10.1080/22221751.2025.2542246
Dvorak M., Arbon D., Salát J., Fořtová A., Pajuelo Reguera D., Frčková T., Holoubek J., Balounová J., Procházka J., Sedláček R., Růžek D. (2025) Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice. Journal of General Virology 106 : 2161.
DOI: 10.1099/jgv.0.002161
Holoubek J., Salát J., Matkovic M., Bednar P., Novotný P., Hradilek M., Majerová T., Rosendal E., Eyer L., Fořtová A., Beránková M., Bell-Sakyi L., Överby A.K., Cavalli A., Bonomi M., Rey F.A., Růžek D. (2025) Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious. Nature Communications 16 : 7491.
DOI: 10.1038/s41467-025-62750-6
Maryewski X.A., Krasilnikov M.S., Straková P., Holoubek J., Frčková T., Panina I.S., Krylov N.A., Gvozdev D.A., Denisov V.S., Semenov A. N., Lotosh N.Y., Selishcheva A.A., Gulyak E.L., Kozhemyakin G.L., Korshun V.A., Efremov R.G., Ustinov A.V., Růžek D., Eyer L., Alferova V.A. (2025) Membranea-active singlet oxygen photogenerators as a paradigm for broad-spectrum antivirals: the case of halogenated (BOron)-DIPYrromethenes ACC Applied Materials and Interfaces 17 : 4502–4528.
DOI: 10.1021/acsami.4c17482
Rosendal E., Bisikalo K., Willekens S.M.A., Lindgren M., Holoubek J., Svoboda P., Lappalainen A., Könighofer E., Mirgorodskaya E., Nordén R., Morini F., Rosenbaum W., Růžek D., Anastasina M., Merits A., Butcher S.J., Nilsson E., Överby A.K. (2025) The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virus. Journal of Virology 99 : e00870-25.
DOI: 10.1128/jvi.00870-25
Holoubek J., Salát J., Kotouček J., Kastl T., Vancová M., Huvarová I., Bednář P., Bednářová K., Růžek D., Renčiuk D., Eyer L. (2024) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Antiviral Research 221 : 105767.
DOI: 10.1016/j.antiviral.2023.105767
Holoubek J., Salát J., Kotouček J., Kastl T., Vancová M., Huvarová I., Bednář P., Bednářová K., Růžek D., Renčiuk D., Eyer L. (2023) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Antiviral Research 221 : 105767.
DOI: 10.1016/j.antiviral.2023.105767
Kakuk B., Dörmő Á., Csabai Z., Kemenesi G., Holoubek J., Růžek D., Dani V.É., Dénes B., Torma G., Jakab F., Tóth G.E., Földes F.V., Zana B., Lanszki Z., Harangozó Á., Fülöp Á., Gulyás G., Mizik M., Kiss A.A., Tombácz D., Boldogkői Z. (2023) In-depth temporal transcriptome profiling of monkeypox and host cells using Nanopore sequencing Scientific Data 10 : 262.
DOI: 10.1038/s41597-023-02149-4
Mikhnovets I.E., Holoubek J., Panina I.S., Kotouček J., Gvozdev D.A., Chumakov D.A., Krasilnikov M.S., Zhitlov M.Y., Gulyak E.L., Chistov A.A., Nikitin T.D., Korshun V.A., Efremov R.G., Alferova V.A., Růžek D., Eyer L., Ustinov A.V. (2023) Alkyl derivatives of perylene photosensitizing antivirals: towards understanding the influence of lipophilicity International Journal of Molecular Sciences 24 : 16483.
DOI: 10.3390/ijms242216483
Straková P., Bednar P., Kotouček J., Holoubek J., Fořtová A., Svoboda P., Štefánik M., Huvarová I., Simeckova P., Korshun V.A., Růžek D., Eyer L. (2023) Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion inactivation Virus Research 334 : 199158.
DOI: 10.1016/j.virusres.2023.199158
Holoubek J., Bednářová K., Haviernik J., Huvarová I., Dvořáková Z., Černý J., Outlá M., Salát J., Konkol'ová E., Boura E., Růžek D. (2022) Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology Nucleic Acids Research 50 : 4574–4600.
DOI: 10.1093/nar/gkac225

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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