RNDr. Martin Palus, Ph.D.

Job Position: Head of Laboratory - Laboratory of Arbovirology

Contact details

Phone: +420 387775145
E-mail: palus@paru.cas.cz
Room: 313c/324

Description

Research interests

My research activity is the study of human viral infections, disease development and its treatment options.

Interest is focused on tick-borne encephalitis virus and related viruses transmitted by ticks and mosquitoes, as well as other viruses that require attention, such as SARS-CoV2.

Curriculum vitae

Education

Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic

2012-2016

Ph.D. (hons.)

Infectious Biology

Tick-borne encephalitis – from pathogenesis to therapy

2015

RNDr.

Clinical Biology

Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system

2009-2012

MSc.

Clinical Biology

The role of the host genetic background on the pathogenesis of tick-borne encephalitis

2007-2009

2006-2009

BSc. (hons.)

Biology

Biology-Biomedical Laboratory Techniques

Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background

Employment

2014-present:

Researcher

Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic

2011-present:

Head of Lab

Laboratory of Arbovirology Institute of  Parasitology, Biology Centre, Czech Academy of the Sciences

2011-2012:

Assistant

Laboratory of Biological Monitoring and Protection, The National Institute for Nuclear, Chemical and Biological Protection, Czech Republic

2009:

Assistant

Dept. of Parasite Immunology , Institute of Parasitology, Biology Centre,  Czech Academy of the Sciences

Research Funding (PI)

2023

Neuropathogenesis linked to NS1 protein of tick-borne encephalitis virus; The Czech Science Foundation (GACR); (2023 - 2025)

2022

Verification of the possibility of using a mouse antibody against the protein of the tick-borne encephalitis virus for the purposes of diagnosis of tick-borne encephalitis by the ELISA method; Technology Agency of the Czech Republic GAMA2;

2020:

Neurovascular unit cells interactions leading to the blood-brain barrier breakdown during tick-borne encephalitis; The Czech Science Foundation (GACR);  (2020 - 2022)

2020:

Identification and characterization of TBEV-neutralizing and cross-reactive antibodies from individuals that are convalescent from flaviviral infection; Programme for research and mobility support of starting researchers from Czech Academy of Sciences (2020-2021)

2017:

Programme of Support of Postdoctoral Fellowships from Czech Academy of Sciences (2017-2018)

2015:

Role of the human brain microvascular endothelial cells during tick-borne encephalitis virus infection in the central nervous system; Grant Agency of the University of South Bohemia

2014:

Role of the human non-neural cells in the neuronal injury during tick-borne encephalitis; Grant Agency of the University of South Bohemia in Ceske Budejovice

Postgraduate Courses and Internships

2020-2021:

Internship: Immunology and Infectious Disease (Davide Robbiani), Institute for Research in Biomedicine, Switzerland

2014:

PREDEMICS, National Institute for Infectious Diseases “L. Spallanzani” – Rome: Workshop on zoonotic features of viral infections from the animal reservoir to pandemic emergence

2012:

Institute of Postgraduate Education in Medicine in Prague: Methods in Laboratory Medicine (accredited qualification course)

2011:

Erasmus Programme:  Arbovirus Pathogenesis Group, The Roslin Institute and Royal (Dick)School of Veterinary Studies, The University of Edinburgh (4 mos.)

Honors

2021:

Prize by the President of Czech Academy of Sciences for young scientists for outstanding results

2018:

Otto Wichterle's Award for selected, exceptionally high-quality and promising scientists from the Czech Academy of Sciences

2017:

Dean’s Award for excellent scientific results during Ph.D. studies. Faculty of Science, University of South Bohemia

2015:

Award for the best Czech and Slovak young microbiologist of the year (Czechoslovak Society for Microbiology; XXIV. Tomasek Days of young microbiologists, Brno)

2013:

Best poster award (Moscow, “Chumakov IPVE” RAMS, Up-to-date problems of TBE)

Publications

     

ORCID ID: 0000-0002-4279-7092

WoS RID: N-1263-2017

Scopus Author ID=25825507600

 

       

Selected conferences contribution (talk/poster)

2023

15th International Symposium on Ticks and Tick-borne Diseases; Germany, Weimar (invited)

2022

10th Tick and Tick-Borne Pathogen Conference, Murighiol, Romania

2022

Konference: Národní institut virologie a bakteriologie, Czech Republic, Kutná Hora

2022

XXIV. Hradecké virologické dny, Czech Republic, Hradec Králové

2022

24th International Symposium on Signal Transduction at the Blood-Brain Barriers, Bari, Italy

2019:

22nd International Symposium on Signal Transduction at The Blood-Brain Barriers, Germany, Würzburg

2019:

The 67th Annual Meeting of the Japanese Society for Virology, Japan, Tokyo

2019:

Joint CzechoSlovak Virology Conference 2019 and 1st SK-AT Structural Virology Meeting, Bratislava

2018:

21nd International Symposium on Signal Transduction at the Blood Brain Barriers, Romania, Arad

2018:

28. Pečenkovy epidemiologické dny, České Budějovice

2017:

Tick and Tick-borne Pathogens 9 (One Health), Australia, Cairns

2017:

Joint CzechoSlovak Virology Conference 2017, České Budějovice

2015:

International Symposium on Flaviviruses: Structure and Immunity, Austria, Vienna

Selected applied research

0550809 - FZÚ 2022 RIV CZ cze L - Prototyp, funkční vzorek Antifoulingový povrch biočipu s terpolymerní vrstvou postmodifikovanou specifickou protilátkou pro kvantitativní stanovení viru SARS-CoV-2 v klinických vzorcích pomocí metody QCM.

0555327 - BC 2022 RIV cze P1 - Užitný vzor, průmyslový vzor Sada primerů pro amplifikační kontrolu pro detekci koronaviru SARS-CoV-2 metodou izotermické amplifikace LAMP a kit pro detekci koronaviru SARS-CoV-2 metodou izotermické amplifikace LAMP.

0542199 - FZÚ 2022 RIV CZ cze L - Prototyp, funkční vzorek Ultra-rezistentní povrch biočipu s terpolymerní vrstvou postmodifikovanou specifickou protilátkou pro rychlou detekci viru SARS-CoV-2 pomocí metody QCM.

0537039 - FZÚ 2021 RIV CZ cze L - Prototyp, funkční vzorek Funkční biočip s ultra-rezistentní polymerní vrstvou pro rychlou detekci viru SARS-CoV-2 pomocí metody QCM.

O - Ostatní výsledky, 2015, Detection of tick-borne encephalitis virus subtypes by RT-qPCR; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra

O - Ostatní výsledky, 2015, Virus Serotyping by TaqMan and SYTO 9 in Single Reaction; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra

O - Ostatní výsledky, 2014, Flavivirus Detection by Quantitative PCR; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra

Other

Member of the International Brain Barriers Society (IBBS)

Member of the World Society for Virology (WSV)

Member of the Czechoslovak Society for Microbiology

Member of the Scientific Council of Institute of Parasitology, Biology Centre CAS

Certificate for the sex and gender dimension of biomedical research completed Libra course

Certificate for the performance of diagnostic methods and preparation of medications

(Institute for Postgraduate education in Medicine, Prague)

Certificate of competency according to § 15d of the Act No. 246/1992 coll. on Protection Animals against Cruelty in present statues at large. Czech University of Life Sciences in Prague, Central commission for Animal Welfare (CCAW)

Publications
Total found: 43 records
Bianchini F., Crivelli V., Abernathy M.E., Guerra C., Palus M., Muri J., Marcotte H., Piralla A., Pedotti M. , de Gasparo R., Simonelli L., Matkovic M., Toscano C., Biggiogero M., Calvaruso V., Svoboda P., Cervantes Rincón T., Fava T., Podešvová L., Shanbhag A.A., Celoria A., Sgrignani J., Štefánik M., Hönig V., Prančlová V., Michalcikova T., Procházka J., Guerrini G., Mehn D., Ciabattini A., Abolhassani H., Jarrossay D., Uguccioni M., Medaglini D., Pan-Hammarström Q., Calzolai L., Fernandez D. , Baldanti F., Franzetti-Pellanda A., Garzoni C., Sedlacek R., Růžek D., Varani L., Cavalli A., Barnes C.O., Robbiani D.F. (2023) Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein Science Immunology 8 : eade0958.
DOI: 10.1126/sciimmunol.ade0958
Fořtová A., Barkhash A.V., Pýchová M., Krbková L., Palus M., Salát J., Růžek D. (2023) Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis Journal of NeuroVirology 29 : 699–705.
DOI: 10.1007/s13365-023-01182-8
Fořtová A., Hönig V., Salát J., Palus M., Pýchová M., Krbková L., Barkhash A.V., Kříha M.F., Chrdle A., Lipoldová M., Růžek D. (2023) Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients Virus Research 324 : 199020.
DOI: 10.1016/j.virusres.2022.199020
Kevély Á., Prančlová V., Sláviková M., Haviernik J., Hönig V., Nováková E., Palus M., Růžek D., Klempa B., Koči J. (2023) Fitness of mCherry reporter tick-borne encephalitis virus in tick experimental models Viruses-Basel 14 : 2673.
DOI: 10.3390/v14122673
Pilipenco A., Forinová M., Mašková H., Hönig V., Palus M., Scott L.N., Víšová I., Vrabcová M., Houska M., Anthi J., Spasovová M., Mustacová J., Štěrba J., Dostálek J., Tung C.P., Yang A.S., Jack R., Dejneka A., Hajdu J., Vaisocherová-Lísalová H. (2023) Negligible risk of surface transmission of SARS-CoV-2 in public transportation Journal of Travel Medicine 30 : taad065.
DOI: 10.1093/jtm/taad065
Ribeiro J., Hartmann D., Bartošová-Sojková P., Debat H., Moos M., Fara J., Šimek P., Palus M., Kučera M., Hajdušek O., Sojka D., Kopáček P., Perner J. (2023) Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq Communications Biology 6 : 517.
DOI: 10.1038/s42003-023-04907-x
Salát J., Huňady M., Svoboda P., Strelcova L., Straková P., Fořtová A., Palus M., Růžek D. (2023) Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs Vaccine 41 : 6150-6155.
DOI: 10.1016/j.vaccine.2023.09.019
Svoboda P., Haviernik J., Bednar P., Matkovic M., Cervantes Rincón T., Keeffe J., Palus M., Salát J., Agudelo M., Nussenzweig M.C., Cavalli A., Robbiani D.F., Růžek D. (2023) A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody Cell Reports 42 : 113149.
DOI: 10.1016/j.celrep.2023.113149
Fořtová A., Hönig V., Palus M., Salát J., Pýchová M., Krbková L., Vyhlídalová T., Kříha M.F., Chrdle A., Růžek D. (2022) Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis Journal of General Virology 103 : 1743.
DOI: 10.1099/jgv.0.001743
Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B., Eyer L., Hönig V., Palus M., Růžek D., Vyhlídalová T., Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine 76 : 103818.
DOI: 10.1016/j.ebiom.2022.103818
Migné C.V., Hönig V., Bonnet S.I., Palus M., Rakotobe S., Galon C., Heckmann A., Výletová E., Devillers E., Attoui H., Růžek D., Moutailler S. (2022) Evaluation of two artificial infection methods of live ticks as tools for studying interactions between tick-borne viruses and their tick vectors Scientific Reports 12 : 491.
DOI: 10.1038/s41598-021-04498-9
Agudelo M., Palus M., Keeffe J., Bianchini F., Svoboda P., Salát J., Peace A., Gazumyan A., Cipolla M., Kapoor T., Guidetti F., Yao K.H., Elsterová J., Teislerová D., Chrdle A., Hönig V., Oliveira T., West A.P., Lee Y.E., Rice C.M., MacDonald M.R., Bjorkman P.J., Růžek D., Robbiani D.F., Nussenzweig M.C. (2021) Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Journal of Experimental Medicine 218 : e20210236.
DOI: 10.1084/jem.20210236
Beliavskaia A., Hönig V., Erhart J., Vyhlídalová T., Palus M., Černý J., Kozlova I., Růžek D., Palomar A.M., Bell-Sakyi L. (2021) Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks. Frontiers in Veterinary Science 8 : 659786.
DOI: 10.3389/fvets.2021.659786
de Gasparo R., Pedotti M., Simonelli L., Nickl P., Mueckschh F., Cassaniti I., Percivalle E., Lorenzi J.C.C., Mazzola F., Magrì D., Michalcikova T., Haviernik J., Hönig V., Mrazkova B., Polakova N., Fortova A., Tureckova J., Iatsiuk V., Di Girolamoa S., Palus M., Zudova D., Bednar P., Bukova I., Bianchini F., Mehni D., Nencka R., Straková P., Pavlis O., Rozman J., Gioria S., Sammartino J.C., Giardina F., Gaiarsak S., Hammarström Q.P., Barnes C.O., Bjorkmann P.J., Calzola L., Piralla A., Baldanti F., Nussenzweig M.C., Bieniasz P.D., Hatziioannouh T., Procházka J., Sedlacek R., Robbiani D.F., Růžek D., Varani L. (2021) Bispecific antibody neutralizes SARS-CoV-2 variants, protects mice from disease and prevents escape Nature 593 : 424–428.
DOI: 10.1038/s41586-021-03461-y
Forinová M., Pilipenco A., Víšová I., Lynn N.S., Dostálek J., Mašková H., Hönig V., Palus M., Selinger M., Kočová P., Dycka F., Štěrba J., Houska M., Vrabcová M., Horak P., Anthi J., Tung C.P., Yu C.M., Chen C.Y., Huang Y.C., Tsai P.H., Lin S.Y., Hsu H.J., Yang A.S., Dejneka A., Vaisocherová-Lísalová H. (2021) Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples ACS Applied Materials and Interfaces 50 : 60612–60624.
DOI: 10.1021/acsami.1c16930
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185 : 104968.
DOI: 10.1016/j.antiviral.2020.104968
Petry M., Palus M., Leitzen E., Mitterreiter J.G., Huang B., Kröger A., Verjans G.M.G.M., Baumgärtner W., Rimmelzwaan G.F., Růžek D., Osterhaus A., Prajeeth C.K. (2021) Immunity to TBEV related flaviviruses with reduced pathogenicity protects mice from disease but not from TBEV entry into the CNS Vaccines 9 : 196.
DOI: 10.3390/vaccines9030196
Salát J., Huňady M., Schanilec P., Straková P., Štefánik M., Svoboda P., Strelcova L., Bojcukova J., Palus M., Růžek D. (2021) Experimental and natural infections of tick-borne encephalitis virus in dogs Viruses-Basel 13 : 2039.
DOI: 10.3390/v13102039
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2020) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: a new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185 : 104968.
DOI: 10.1016/j.antiviral.2020.104968
Helmová R., Hönig V., Tykalová H., Palus M., Bell-Sakyi L., Grubhoffer L. (2020) Tick-borne encephalitis virus adaptation in different host environments and existence of quasispecies Viruses 12 : 902.
DOI: 10.3390/v12080902

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CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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