RNDr. Alena Panicucci Zíková, Ph.D.

Job Position: Head of Laboratory - Laboratory of Functional Biology of Protists

Contact details

Phone: +420 387775482
E-mail: azikova@paru.cas.cz
Room: PARU II, 2.06


Research interests

  • unique properties of the mitochondrial respiratory complexes in Trypanosoma brucei andLeishmania spp.
  • screening chemical compounds that inhibit enzymes of the purine salvage pathway, thus validating this pathway as a drug target
Curriculum vitae

Professional Experience:

2010 - now     Group leader, Institute of Parasitology, Biology Centre ASCR,  České Budějovice, Czech Republic


2011                 Research stay supported by EMBO short fellowship at the MRC Mitochondrial, Biology Unit, Cambridge, UK;  hosting lab: John E. Walker                                laboratory (6 weeks)

2005 – 2009    Postdoctoral scientist, Seattle Biomedical Research Institute, Seattle, USA

2004 – 2005    Research stay supported by NATO fellowship at the Seattle Biomedical Research Institute, Seattle, USA; hosting lab: prof. Ken Stuart (6 months)

2001                  Research stay, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; hosting lab: prof. Rob Benne  (3 months)


Education and Academic Qualification:

2006               Ph.D. in Molecular Parasitology, Department of Parasitology, University of South Bohemia, Faculty of Biological Sciences, České Budějovice,                          Czech Republic

2002                M.Sc. - Master in Parasitology, University of South Bohemia, Faculty of Biological Sciences, České Budějovice, Czech Republic



Advanced Methods in Molecular Biology
Faculty of Science, University of South Bohemi

Total found: 34 records
Gahura O., Panicucci Zíková A. (2019) Isolation of F1-ATPase from the Parasitic Protist Trypanosoma brucei Journal of visualized experiments : JoVE 22 : e58334.
DOI: 10.3791/58334
Nenarokova A., Záhonová K., Krasilnikova M., Gahura O., McCulloch R., Zíková A., Yurchenko V., Lukeš J. (2019) Causes and effects of loss of classical nonhomologous end joining pathway in parasitic eukaryotes mBio 10 : e01541-19.
DOI: 10.1128/mBio.01541-19
Terán D., Doleželová E., Keough D., Hocková D., Panicucci Zíková A., Guddat L. (2019) Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP FEBS Journal 286 : 4721-4736.
DOI: 10.1017/S0022149X19000737
Doleželová E., Terán D., Gahura O., Kotrbová Z., Procházková M., Keough D., Špaček P., Hocková D., Guddat L., Zíková A. (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery PLOS Neglected Tropical Diseases DOI: 10.1371/journal.pntd.0006301
Gahura O., Panicucci B., Váchová Hana, Walker John E., Zíková A. (2018) Inhibition of F1 -ATPase from Trypanosoma brucei by its regulatory protein inhibitor TbIF1 FEBS Journal DOI: 10.1111/febs.14672
Gahura O., Šubrtová K., Váchová Hana, Panicucci B., Fearnley Ian M., Harbour Michael E., Walker John E., Zíková A. (2018) The F1 -ATPase from Trypanosoma brucei is elaborated by three copies of an additional p18-subunit FEBS Journal 285 : 614-628.
DOI: 10.1111/febs.14364
Montgomery M.G., Gahura O., Leslie A.G., Zíková A., Walker J.E. (2018) ATP synthase from Trypanosoma brucei has an elaborated canonical F1-domain and conventional catalytic sites. Proceedings of the National Academy of Sciences of the United States of America 115 : 2102-2107.
DOI: 10.1073/pnas.1720940115
Procházková M., Panicucci B., Panicucci Zíková A. (2018) Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1 Scientific Reports 8 : 5135.
DOI: 10.1038/s41598-018-23472-6
Panicucci B., Gahura O., Zíková A. (2017) Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite PloS Neglected Tropical Diseases 11 : e0005552.
DOI: 10.1371/journal.pntd.0005552
Zíková A., Verner Z., Nenarokova A., Michels P.A.M., Lukeš J. (2017) A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex PLOS Pathogens 13 : e1006679.
DOI: 10.1371/journal.ppat.1006679

Documents to download:
Zikova et al. 2017 PLOS Pathogens (pdf)
Alkhaldi A., Martinek J., Panicucci B., Dardonville C., Zíková A., de Koning H. (2016) Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei International Journal for Parasitology: Drugs and Drug Resistance 6 : 23-34.
DOI: 10.1016/j.ijpddr.2015.12.002
Hashimi H., Kaltenbrunner S., Zíková A., Lukeš J. (2016) Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet PLoS Pathogens 12 : e1005492.
DOI: 10.1371/journal.ppat.1005492

Documents to download:
Hashimi et al. 2016 PLoS Pathog (pdf)
Terán D., Hocková D., Česnek M., Zíková A., Naesens L., Keough D., Guddat L. (2016) Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase Scientific Reports 6 : 35894.
DOI: 10.1038/srep35894
Zíková A., Hampl V., Paris Z., Týč J., Lukeš J. (2016) Aerobic mitochondria of parasitic protists: diverse genomes and complex functions. Molecular and Biochemical Parasitology 209 : 46-57.
DOI: 10.1016/j.molbiopara.2016.02.007

Documents to download:
Zikova et al. 2016 MBP (pdf)
Gnipová A., Šubrtová K., Panicucci B., Horváth A., Lukeš J., Zíková A. (2015) The ADP/ATP carrier and its relationship to OXPHOS in an ancestral protist, Trypanosoma brucei. Eukaryotic Cells 14 : 297-310.
DOI: 10.1128/EC.00238-14

Documents to download:
Gnipova et al. 2015 ECell (pdf)
Šubrtová K., Panicucci B., Zíková A. (2015) ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes Plos Pathogens 10 : e1004660.
DOI: 10.1371/journal.ppat.1004660
Verner Z., Basu S., Benz C., Dixit S., Dobáková E., Faktorová D., Hashimi H., Horáková E., Huang Z., Paris Z., Pena P., Ridlon L., Týč J., Wildridge D., Zíková A., Lukeš J. (2015) The malleable mitochondrion of Trypanosoma brucei Internation Review of Cell and Molecular Biology 315 : 73-151.
DOI: 10.1016/bs.ircmb.2014.11.001

Documents to download:
Verner-IRCMB-2015 (pdf)
Zíková A., Oborník M., Lukeš J. (2015) Fancy a gene? A surprisingly complex evolutionary history of peroxiredoxins. Microbial Cell 2 : 5-13.
DOI: 10.15698/mic2015.02.189

Documents to download:
Zikova et al. 2015 (pdf)
Gnipová A., Panicucci B., Paris Z., Verner Z., Horváth A., Lukeš J., Zíková A. (2012) Disparate phenotypic effects from the knockdown of various Trypanosoma brucei cytochrome c oxidase subunits. Molecular and Biochemical Parasitology 184 : 90-98.
DOI: 10.1016/j.molbiopara.2012.04.013

Documents to download:
2012_Gnipova_MBP_90 (pdf)
Acestor N., Zíková A., Dalley R., Anupama A., Panigrahi A., Stuart K. (2011) Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form. Molecular & Cellular Proteomics 10 : 9.
DOI: 10.1074/mcp.M110.006908

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Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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