doc. RNDr. Daniel Růžek, Ph.D.

Job Position: Head of Laboratory - Laboratory of Arbovirology

Contact details

Phone: +420 387775458
E-mail: ruzekd@paru.cas.cz
Room: 316

Description

Research interests

  • virology: arboviruses, zoonoses, neurovirology
Curriculum vitae
born 30. 4. 1981 in Jindřichův Hradec, Czechoslovakia

Education

  • 2013: Associate Professor (docent) in the field of Medical Microbiology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic
  • 2005-2008: Ph.D.(Molecular and Cellular Biology and Genetics) Academy of Sciences of the Czech Republic, Institute of Parasitology, and University of South Bohemia, Faculty of Science
  • 2007: RNDr.(Advanced Master’s degree: “Rerum Naturalium Doctor” = Doctor of Natural Sciences; Clinical Biology) University of South Bohemia, Faculty of Biological Sciences
  • 2003-2005: MSc.(Clinical Biology; graduated with the highest honours), University of South Bohemia, Faculty of Biological Sciences
  • 2000-2003: BSc.(Biology – Biomedical Laboratory Techniques) University of South Bohemia, Faculty of Biological Sciences
  • 2000: High School graduation (Czech language and literature, German language, Biology, Chemistry; graduated with the highest honours), High School in Český Krumlov

Postgraduate Courses

  • 2013: Mendel University in Brno: Basic pedagogical skills in university education (qualification course)
  • 2012: Institute of Postgraduate Education in Medicine in Prague: Methods in Laboratory Medicine (accredited qualification course)
  • 2011: British Society for Immunology Summer School 2011, Atlantic College, St. Donat’s Castle, Wales, United Kingdom (postgraduate course)
  • 2011: Société de Pathologie Infectieuse de Langue Française, Grenoble, France: “Acute Infectious Encephalitis” (postgraduate course)
  • 2010: Rollins School of Public Health, Emory University, Atlanta, USA: “BSL-4 Science and Safety” (qualification course)

Employment

  • 2014-present: Associate Professor, Faculty of Science, Masaryk University in Brno, Czech Republic
  • 2013-present: Associate Professor, Department of Medical Biology, Faculty of Science, Universtity of South Bohemia, České Budějovice, Czech Republic
  • 2012-present: Head of the Department of Virology, Head of the Research Group on Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic
  • 2011-present: Research Scientist, Institute of Parasitology, Academy of Sciences of the Czech Republic
  • 2009-2011: Postdoctoral Scientist, Institute of Parasitology, Academy of Sciences of the Czech Republic
  • 2008-2009: Postdoctoral Scientist, Texas Biomedical Research Institute, Department of Virology and Immunology, San Antonio, Texas, USA
  • 2008-2013: Assistant Professor (Medical Virology), University of South Bohemia, Faculty of Science, Department of Medical Biology
  • 2005-2009: Research Assistant, Institute of Parasitology, Academy of Sciences of the Czech Republic
  • 2004-2008: Assistant, University of South Bohemia, Faculty of Biological Sciences, Department of Medical Biology

Research Internships

  • 2011 (2 weeks): Laboratory of Neurovirology and Inflammation Biology, Centre for Cellular and Molecular Biology, Hyderabad, India
  • 2008-2009 (1 year): Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, USA
  • 2008 (2 weeks): Laboratoire de Physiopathologie de la Barriere Hemato-Encephalique, Faculté des Sciences Jean Perrin, Université d’Artois, Lens, France
  • 2006 (2 weeks): Royal (Dick) School of Veterinary Studies, Centre for Tropical Veterinary Medicine, University of Edinburgh, United Kingdom

Professional Associations

  • Member of the World Academy of Science, Engineering, and Technology, WASET 
  • Member of the International Scientific Working Group on Tick-borne Encephalitis
  • Member of the Czechoslovak Society for Microbiology
  • Editorial Board Member: World Journal of Virology (since 2010), American Journal of Infectious Diseases and Microbiology (since 2012), The Scientific World Journal (since 2013), Medical Virology (Russia) (Медицинская вирусология) (since 2013), Epidemioogy and Vaccinal Prevention Scientific and Practical Journal (since 2014)
  • Chairman of the Ethical Committee of the Institute of Parasitology (since 2011)
  • Member of the Expert Committee for Biological Sciences of the Research, Development and Innovation Council, Office of the Government of the Czech Republic
  • Peer-reviewer for the scientific journals (Virology, Vector-Borne and Zoonotic Diseases, Expert Reviews on Antimicrobial Therapy, Journal of Virological Methods, Current Microbiology, European Journal of Neurology, Journal of Clinical Virology, Viral Immunology, Intervirology, World Journal of Pediatrics, Journal of Internal Medicine, The Scientific World Journal, World Journal of Virology, Vaccine, World Journal of Gastenterology, PLoS One, PLoS Neglected Tropical Diseases, American Journal of Infectious Diseases and Microbiology, Journal of Medical Virology, Folia Parasitologica, Advances in Virus Research, Infection, Genetics and Evolution, African Journal of Microbiology Research, BMC Infectious Diseases, BMC Veterinary Research, Pathogens, Ticks and Tick-borne Diseases, Future Virology, Scientific Reports, Virus Research, Journal of General Virology, International Journal of Infectious Diseases, Journal of Infection and others)
  • Reviewer of the book: Singh, S.K. Viral infections and global health. Wiley Blackwell, New Jersey (2014); review published in Microbiology Today (2014), 41:141.
  • member of the International Conference Committee: ICVID 2014: International Conference on Virology and Infectious Diseases, London, UK
  • national representative at the International Committee for Taxonomy of Viruses (ICTV)

Certificates

  • Certificate for the performance of diagnostic methods and preparation of medications (Institute for Postgraduate education in Medicine, Prague) 
  • Certificate of competency according to § 17 of the Act No. 246/1992 coll. on Protection Animals against Cruelty in present statues at large. University of Veterinary and Pharmaceutical Sciences Brno and Central commission for Animal Welfare (CCAW) (licence č. V/5/2005/24)
  • Certificate of Completion “real-time PCR” (Applied Biosystems, Prague 2010)

Honors

  • 2000: 1st Prize, Student Scientific Work 2000, South Bohemia Region, Czech Republic
  • 2000: Special Award, Czech National Round of the Student Scientific Work 2000, Rožnov pod Radhoštem, Czech Republic
  • 2006: 1st Prize, Student Scientific Work 2006, Student Grant Agency of the Faculty of Biological Sciences, University of South Bohemia
  • 2006: Travel Grant for young researches, European Society for Clinical Virology (Birmingham, UK)
  • 2009: Extraordinary Prize by the Dean for Excellent Scientific Results during Ph.D. Studies. Faculty of Science, University of South Bohemia
  • 2009: Sinnecker-Kunz Award for young researchers in the field of tick-borne pathogens (Weimar, Germany)
  • 2009: Memory Medal of the city Vyšší Brod (Czech Republic)
  • 2011: Travel Grant, Société de Pathologie Infectieuse de Langue Française, France

Teaching Medical Virology
Faculty of Science University of South Bohemia




Publications
Total found: 76 records
Eyer L., Nencka R., De Clercq E., Seley-Radtke K., Růžek D. (2018) Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses. vAntiviral Chemistry and Chemotherapy 26 : 1-28.
DOI: 10.1177/2040206618761299
Füzik T., Formanová P., Růžek D., Yoshii K., Niedrig M., Plevka P. (2018) Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody Nature Communications 9 : 436.
DOI: 10.1038/s41467-018-02882-0
Haviernik J., Štefánik M., Fojtikova M., Kali S., Noël T., Rudolf I., Hubálek Z., Růžek D., Eyer L. (2018) Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses. Viruses 10 : 184.
DOI: 10.3390/v10040184
Müllerová J., Elsterová J., Černý J., Ditrich O., Žárský J., Culler L.E., Kampen H., Walther D., Coulson S., Růžek D., Grubhoffer L. (2018) No indication of arthropod-vectored viruses in mosquitoes (Diptera: Culicidae) collected on Greenland and Svalbard Polar Biology 11 : 1581–1586.
DOI: 10.1007/s00300-017-2242-9
Palus M., Sohrabi Y., Broman K.W., Strnad H., Šíma M., Růžek D., Volkova V., Slapničková M., Vojtíšková J. , Mrázková L., Salát J., Lipoldová M. (2018) A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus. BMC Neuroscience 19 : 39.
DOI: 10.1186/s12868-018-0438-8
Růžek D., Yoshii K., Bloom M.E., Gould E. (2018) Tick-borne encephalitis virus - Virology. In: G. Dobler, W. Erber and H.-J. Schmitt (Eds.), Tick-Borne Encephalitis (TBE) Springer 12–26.
Salát J., Formanová P., Huňady M., Eyer L., Palus M., Růžek D. (2018) Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use Vaccine 36 : 7257–7261.
DOI: 10.1016/j.vaccine.2018.10.034
Šebera J., Dubánková A., Sychrovský V., Růžek D., Boura E., Nencka R. (2018) The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors Scientific Reports 8 : 11132.
DOI: 10.1038/s41598-018-29459-7
Širmarová J., Salát J., Palus M., Hönig V., Langhansová H., Holbrook M., Růžek D. (2018) Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells Emerging Microbes & Infections 7 : 175.
DOI: 10.1038/s41426-018-0177-z
Štefánik M., Formanová P., Bílý T., Vancová M., Eyer L., Palus M., Salát J., Braconi C. T. , Zanotto De A. P., Gould E., Růžek D. (2018) Characterisation of Zika virus infection in primary human astrocytes. BMC Neuroscience BMC Neuroscience 18 : 1136.
DOI: 10.1186/s12868-018-0407-2
Bukin Y.S., Dzhioev Y.S., Tkachev S., Kozlova I., Paramonov A.I., Růžek D., Qu Z., Zlobin V.I. (2017) A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties Virus Research 238 : 124-132.
DOI: 10.1016/j.virusres.2017.06.006
Demina T.V., Tkachev S., Kozlova L., Doroshenko K., Lisak O.V., Suntsova O.V., Verkhozina M.M., Dzhioev Y., Paramonov A.I., Tikunov A.Y., Tikunova N.V., Zlobin V.I., Růžek D. (2017) Comparative analysis of complete genome sequences of European subtype tick-borne encephalitis virus strains isolated from Ixodes persulcatus ticks, long-tailed ground squirrel (Spermophilus undulatus), and human blood in the Asian part of Russia Ticks and Tick-borne Diseases 8 : 547-553.
DOI: 10.1016/j.ttbdis.2017.03.002
Elsterová J., Palus M., Širmarová J., Kopecký J., Niller H., Růžek D. (2017) Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin Ticks and Tick-borne Diseases 8 : 253-258.
DOI: 10.1016/j.ttbdis.2016.11.007
Eyer L., Kondo H., Zouharova D., Hirano M., Valdés J. J., Muto M., Kasti T., Kobayashi S., Haviernik J., Igarashi M., Kariwa H., Vaculovicova M., Černý J., Kizek R., Kröger A., Lienenklaus S., Dejmek M., Nencka R., Palus M., Salát J., De Clercq E., Yoshii K., Růžek D. (2017) Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness Journal of Virology 91 : e01028-17.
DOI: 10.1128/JVI.01028-17
Eyer L., Zouharova D., Širmarová J., Fojtikova M., Štefánik M., Haviernik J., Nencka R., De Clercq E., Růžek D. (2017) Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses Antiviral Research 142 : 63-67.
DOI: 10.1016/j.antiviral.2017.03.012
Hercík K., Kozák J., Šála M., Dejmek M., Hřebabecký H., Zborníková E., Smola M., Růžek D., Nencka R., Boura E. (2017) Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase. Antiviral Research 137 : 131-133.
DOI: 10.1016/j.antiviral.2016.11.020
Hönig V., Carolan H., Vavrušková Z., Massire C., Mosel M.R., Crowder C., Rounds M., Ecker D., Růžek D., Grubhoffer L., Luft B., Eshoo M. (2017) Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic FEMS Microbiology Ecology 93 : fix129.
DOI: 10.1093/femsec/fix129
Palus M., Vancová M., Širmarová J., Elsterová J., Perner J., Růžek D. (2017) Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity. Virology 507 : 110-122.
DOI: 10.1016/j.virol.2017.04.012
Salát J., Mihalca A., Mihaiu M., Modrý D., Růžek D. (2017) Tick-borne encephalitis in sheep, Romania Emerging Infectious Diseases 23 : 2065-2067.
DOI: 10.3201/eid2312.170166
Straková P., Dufkova L., Širmarová J., Salát J., Bartonička T., Klempa B., Pfaff F., Höper D., Hoffmann B., Ulrich R., Růžek D. (2017) Novel hantavirus identified in European bat species Nyctalus noctula Infection, Genetics and Evolution 48 : 127-130.
DOI: 10.1016/j.meegid.2016.12.025

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CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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