Publications

Total found: 80 records
Sakhon O., Severo M., Kotsyfakis M., Pedra J. (2013) A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva Frontiers in Microbiology 4: article 308.
DOI: 10.3389/fmicb.2013.00308
Schwarz A., Von Reumont B., Erhart J., Chagas A., Ribeiro J., Kotsyfakis M. (2013) De novo Ixodes ricinus salivary gland transcriptome analysis using two next-generation sequencing methodologies FASEB JOURNAL 27: 4745-4756.
DOI: 10.1096/fj.13-232140
Valdés J. J., Schwarz A., Cabeza De Vaca I., Calvo E., Pedra J., Guallar V., Kotsyfakis M. (2013) Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder PloS ONE 8: e62562.
DOI: 10.1371/journal.pone.0062562
Chen G., Severo M., Sakhon O., Choy A., Herron M., Felsheim R., Wiryawan H., Liao J., Johns J., Munderloh U., Sutterwala F., Kotsyfakis M., Pedra J. (2012) Anaplasma phagocytophilum dihydrolipoamide dehydrogenase 1 affects host-derived immunopathology during microbial colonization. Infection and Immunity 80: 3194–3205.
DOI: 10.1128/​IAI.00532-12
Chen G., Severo M., Sohail M., Sakhon O., Wikel S., Kotsyfakis M., Pedra J. (2012) Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells. Parasites & Vectors 5: 229.
DOI: 10.1186/1756-3305-5-229
Chmelař J., Calvo E., Pedra J., Francischetti I., Kotsyfakis M. (2012) Tick salivary secretion as a source of antihemostatics. Journal of Proteomics 75: 3842–3854.
DOI: 10.1016/j.jprot.2012.04.026
Collin N., Assumpçăo T., Mizurini D., Gilmore D., Dutra-Oliveira A., Kotsyfakis M., Sá-Nunes A., Teixeira C., Ribeiro J., Monteiro R., Valenzuela J., Francischetti I. (2012) Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis, blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo. Arteriosclerosis Thrombosis and Vascular Biology 32: 2185–2198.
DOI: 10.1161/ATVBAHA.112.253906
Francischetti I., Oliveira C., Ostera G., Yager S., Debierre-Grockiego F., Carregaro V., Jaramillo-Gutierrez G., Hume J., Jiang L., Moretz S., Lin C., Ribeiro J., Long C., Vickers B., Schwarz R., Seydel K., Iacobelli M., Ackerman H., Srinivasan P., Gomes R., Wang X., Monteiro R., Kotsyfakis M., Sá-Nunes A., Waisberg M. (2012) Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria. Arteriosclerosis, Thrombosis, and Vascular Biology 32: 786–798.
DOI: 10.1161/ATVBAHA.111.240291
Rodrigues J., Oliveira G., Kotsyfakis M., Dixit R., Molina-Cruz A., Jochim R., Barillas-Mury C. (2012) An epithelial serine protease, AgESP, is required for Plasmodium invasion in the mosquito Anopheles gambiae. PLoS ONE 7: e35210.
DOI: 10.1371/journal.pone.0035210
Ronca R., Kotsyfakis M., Lombardo F., Rizzo C., Curra C., Ponzi M., Fiorentino G., Ribeiro J., Arca B. (2012) The Anopheles gambiae cE5, a tight- and fast-binding thrombin inhibitor with post-transcriptionally regulated salivary-restricted expression. Insect Biochemistry and Molecular Biology 42: 610–620.
DOI: 10.1016/j.ibmb.2012.04.008
Schwarz A., Valdés J. J., Kotsyfakis M. (2012) The role of cystatins in tick physiology and blood feeding. Ticks and Tick-borne Diseases 3: 117-127.
DOI: 10.1016/j.ttbdis.2012.03.004
Severo M., Stephens K., Kotsyfakis M., Pedra J. (2012) Anaplasma phagocytophilum: deceptively simple or simply deceptive? Future Microbiology 7: 719-731.
DOI: 10.2217/FMB.12.45
Horká , Staudt V., Klein M., Taube C., Reuter S., Dehzad N., Andersen J., Kopecký J., Schild H., Kotsyfakis M., Hoffmann M., Gerlitzki B., Stassen M., Bopp T., Schmitt E. (2012) The tick salivary protein Sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. Journal of Immunology 188: 2669–2676.
DOI: 10.4049/​jimmunol.1100529
Tsujimoto H., Kotsyfakis M., Francischetti I., Eum J., Strand M., Champagne D. (2012) Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses. PLoS ONE 7: e29964.
DOI: 10.1371/journal.pone.0029964
Calvo E., Mizurini D., Sá-Nunes A., Ribeiro J., Andersen J., Mans B., Monteiro R., Kotsyfakis M., Francischetti I. (2011) Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity. Journal of Biological Chemistry 286: 27998–28010.
DOI: 10.1074/jbc.M111.247924
Chmelař J., Oliveira C., Řezáčová P., Francischetti I., Kovářová Z., Pejler G., Kopáček P., Ribeiro J., Mareš M., Kopecký J., Kotsyfakis M. (2011) A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood 117: 736–744.
DOI: 10.1182/blood-2010-06-293241
Sojka D., Francischetti I., Calvo E., Kotsyfakis M. (2011) Cysteine proteases from bloodfeeding arthropod ectoparasites. Advances in experimental medicine and biology 712: 177–191.
DOI: 10.1007/978-1-4419-8414-2_11
Francischetti I., Kotsyfakis M., Andersen J., Lukszo J. (2010) Cyr61/CCN1 Displays High-Affinity Binding to the Somatomedin B (1-44) Domain of Vitronectin. PLoS ONE 5: e9356.
DOI: 10.1371/journal.pone.0009356
Kotsyfakis M., Horká , Salát J., Andersen J. (2010) The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model. Molecular Microbiology 77: 456–470.
DOI: 10.1111/j.1365-2958.2010.07220.x
Salát J., Paesen G., Řezáčová P., Kotsyfakis M., Kovářová Z., Šanda M., Majtán J., Grunclová L., Horká , Andersen J., Brynda J., Horn M., Nunn M., Kopáček P., Kopecký J., Mareš M. (2010) Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata. Biochemical Journal 429: 103–112.
DOI: 10.1042/BJ20100280

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Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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