James Jason Valdés, Ph.D.

Job Position: Research Scientist - Laboratory of Arbovirology

Contact details

Phone: +420 387775458
E-mail: valdjj@gmail.com
Room: 614

Curriculum vitae

James J. Valdés, Ph.D. in Biology (2009)
Research ID: G-9812-2014

Research activities
As a research scientist, my activities have been extensive and diverse drawing from a scientific background in neuroscience, behavioral psychology, histology, parasitology, virology, structural biology and computational biochemistry. My current focus is investigating how to improve antiviral drugs in the form of nucleotide analogs and gene silencers (small interfering RNAs).

Scientific and academic positions

  • 2015-Present: Research Scientist, Department of Virology, Veterinary Research Institute (Brno).
  • 2011-Present: Research Scientist, Biology Centre, Institute of Parasitology (České Budějovice).
  • 2012-Present: Lecturer, Faculty of Science, University of South Bohemia (České Budějovice).
  • 2010-2014: Visiting Scientist, Life Science Department, Barcelona Supercomputing Center (Spain).

Fellowships and Research Grants

  • 2015 MODBIOLIN (grant agreement nº 316304), financed by the European Union Seventh Framework Programme (FP7/2077-2013)
  • 2012-2015 Postdok BIOGLOBE (CZ.1.07/2.3.00/30.0032), co-financed by the European Social Fund and the state budget of the Czech Republic
  • 2010 NSF Cyberinfrastructure-Partnership for International Research and Education (CI-PIRE) Fellowship, Florida International University (Miami, FL)

Publications
Total found: 42 records
Artigas-Jerónimo S., Comín J.J.P., Villar M., Contreras M., Alberdi P., Viera I.L., Soto L., Cordero R., Valdés J. J., Cabezas-Cruz A., Estrada-Peňa A., de la Fuente J. (2020) A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model. Vaccines 8 : 77.
DOI: 10.3390/vaccines8010077
Gobl J., Sinha D., Šíma R., Perner J., Kopáček P., Valdés J. J., Rego R. O. M., Cabezas-Cruz A. (2020) Histone Methyltransferase DOT1L Is Involved in Larval Molting and Second Stage Nymphal Feeding in Ornithodoros moubata Vaccines 8 : 157.
DOI: 10.3390/vaccines8020157
Štefánik M., Valdés J. J., Ezebuo F.C., Haviernik J., Uzochukwu I.C., Fojtikova M., Salát J., Eyer L., Růžek D. (2020) FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells Microorganisms 8 : 599.
DOI: 10.3390/microorganisms8040599
Cabezas-Cruz A., Tonk M. , Bleackley M.R., Valdés J. J., Barrero R.A., Moutailler S., Vilcinskas A., Richard-Forget F., Anderson M.A., Rodriguez-Valle M. (2019) Antibacterial and antifungal activity of defensins from the Australian paralysis tick, Ixodes holocyclus. Ticks and tick-borne diseases. 10 : 101269.
DOI: 10.1016/j.ttbdis.2019.101269
Eyer L., Nougairède A., Uhlířová M., Driouich J.S., Zouharova D., Valdés J. J., Haviernik J., Gould E., De Clercq E., de Lamballerie X., Růžek D. (2019) An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. Journal of Virology 93 : pii: e00367-19.
DOI: 10.1128/JVI.00367-19
Valdés J. J., Miller A. (2019) New opportunities for designing efective small interfering RNAs Scientific Reports 9 : 16146.
DOI: 10.1038/s41598-019-52303-5
Artigas-Jerónimo S., Villar M., Cabezas-Cruz A., Valdés J. J., Estrada-Peňa A., Alberti P., de la Fuente J. (2018) Functional Evolution of Subolesin/Akirin Frontiers in Physiology 9 : 1612.
DOI: 10.3389/fphys.2018.01612
Cabezas-Cruz A., Espinosa P.J., Alberdi P., Šimo L., Valdés J. J., Mateos-Hernández L., Contreras M., Rayo M.V., de la Fuente J. (2018) Tick galactosyltransferases are involved in α-Gal synthesis and play a role during Anaplasma phagocytophilum infection and Ixodes scapularis tick vector development. Scientific Reports 8 : 14224.
DOI: 10.1038/s41598-018-32664-z
Alberdi P., Valdés J. J., Villar J.J., de la Fuente J. (2017) Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum. Frontiers in Bioscience-Landmark 22 : 1830-1844.
Alberdi P., Valdés J. J., Villar M., de la Fuente J. (2017) Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis Frontiers in Cellular and Infection Microbiology 7 : 23.
DOI: 10.3389/fcimb.2017.00023
Contreras M., Alberdi P., Mateos-Hernández L., Fernández de Mera I.G., García-Pérez A., Vancová M., Villar M., Ayllón N., Valdés J. J., Stuen S., Gortazar C., de la Fuente J. (2017) Anaplasma phagocytophilum MSP4 and HSP70 Proteins Are Involved in Interactions with Host Cells during Pathogen Infection. Frontiers in Cellular and Infection Microbiology 7 : 307.
DOI: 10.3389/fcimb.2017.00307
Eyer L., Kondo H., Zouharova D., Hirano M., Valdés J. J., Muto M., Kasti T., Kobayashi S., Haviernik J., Igarashi M., Kariwa H., Vaculovicova M., Černý J., Kizek R., Kröger A., Lienenklaus S., Dejmek M., Nencka R., Palus M., Salát J., De Clercq E., Yoshii K., Růžek D. (2017) Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness Journal of Virology 91 : e01028-17.
DOI: 10.1128/JVI.01028-17
Valdés J. J., Butterill P. T., Růžek D. (2017) Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors. Biochemical and Biophysical Research Communications 492 : 652-658.
DOI: 10.1016/j.bbrc.2017.03.068
Alberdi P., Ayllón N., Valdés J. J., Pierce R., Villar M., de la Fuente J. (2016) Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis Epigenetics 11 : 303-319.
DOI: 10.1080/15592294.2016.1163460
Estrada-Peňa A., Valdés J. J., de la Fuente J. (2016) Be aware of ticks when strolling through the park Frontiers for Young Minds 4 : 24.
DOI: 10.3389/frym.2016.00024
Tellier G., Lenne A., Cailliau-Maggio K., Valdés J. J., Martoriati A., Aliouat E., Gosset P., Delaire B., Fréville A., Pierrot C., Khalife J. (2016) Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1 Frontiers in Microbiology 7 : 777.
DOI: 10.3389/fmicb.2016.00777
Tonk M., Bouchut A., Pierrot C., Pierce R., Kotsyfakis M., Rahnamaeian M., Vilcinskas A., Khalife J., Valdés J. J. (2016) Antiplasmodial activity is an ancient and conserved feature of tick defensins Frontiers in Microbiology 7 : 1682.
DOI: 10.3389/fmicb.2016.01682
Valdés J. J., de la Fuente J. (2016) Control of vector-borne infectious diseases by human immunity against α-Gal Expert review of vaccines 15 : 953-955.
DOI: 10.1080/14760584.2016.1181547
Valdés J. J., Gil V., Butterill P. T., Růžek D. (2016) An all-atom, active site exploration of antiviral drugs that target Flaviviridae polymerases. Journal of General Virology 97 : 2552-2565.
DOI: 10.1099/jgv.0.000569
Valdés J. J., Šíma R., Butterill P. T., Růžek D., Nuttall P. (2016) Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection. Scientific Reports 6 : 32372.
DOI: 10.1038/srep32372

More publications

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

Staff search