James Jason Valdés, Ph.D.

Job Position: PostDoc - Laboratory of Arbovirology

Contact details

Phone: +420 387775458
E-mail: valdjj@gmail.com
Room: 614

Curriculum vitae

Education

  • 2004-2009 Ph.D. Florida International University (Biology) Doctoral thesis: “Estrogen and Lithium: Facilitating Factors Involved in Brain Cell Signaling Pathways”, Doctoral Advisor: Dr. Ophelia I. Weeks
  • 1998-2001 B.A. Florida International University (Psychology)
  • 1996-1998 A.A. Miami-Dade Community College (Psychology)

Academic Positions

  • Spring 2010 Supervisor for the Minority Access to Research Careers (MARC) Fellow Peer-to-Peer Workshops, Florida International University, Department of Biological Sciences, Miami, FL
  • 2004 - 2005 Teaching Assistant, Florida International University, Department of Biological Sciences, Miami, FL
  • 2003 – 2010 Minority Undergraduate Mentor in Biological Research, Florida International University, Department of Biological Sciences, Miami, FL

Positions and Employment

  • 2011-Present Junior Research Scientist, Laboratory of Genomics and Proteomics of Disease Vectors Biology centre of ASCR, Institute of Parasitology (České Budějovice, Czech Republic)
  • Summer 2011 Visiting Scientist, Center for Tropical Plant Conservation, Fairchild Tropical Botanic Garden (Coral Gables, FL)
  • Summer 2010 Postdoctoral Fellow, ICREA Life Science Department at the Barcelona Supercomputing Center (Barcelona, Spain)
  • Spring 2010 Neurobiology consultant for 3-D medical animation to depict protein-signaling cascades, Miami, FL (for the proprietor My3DMed; http://my3dmed.com/)
  • 2003 - 2010 Laboratory Manager, Florida International University, Department of Biological Sciences, Miami, FL
  • 2000 - 2003 Assistant Coordinator, Roots in the City and Black Florida Exhibit, Florida International University, Department of Psychology, Miami, FL

Academic, Scientific and Professional Memberships

  • 2006 – 2007 Secretary, Molecular and Cellular Biology Club, Florida International University (Miami, FL)
  • 2006 Member, Society for Neuroscience
  • 2005 – 2006 President, Molecular and Cellular Biology Club, Florida International University (Miami, FL)
  • 2005 Member, American Association of Anatomists
  • 2004 – 2005 Graduate Student Organization Representative, Molecular and Cellular Biology Club, Florida International University (Miami, FL)

Fellowships

  • Summer 2010 NSF Cyberinfrastructure-Partnership for International Research and Education (CI-PIRE) Fellowship, Florida International University (Miami, FL)
  • 09/2009 Carl Storm Underrepresented Minority Fellowship, Gordon Research Conferences (West Kingston, RI)
  • 2005 – 2009 NIH/NIGMS Minority Biomedical Research Support/Research Initiative for Scientific Enhancement Graduate Student Fellowship, Florida International University (Miami, FL)

Awards and Certificates

  • 2010 Certified, Global Scholar, Florida International University (Miami, FL)
  • 2009 Travel Award, College of Arts and Sciences, Florida International University (Miami, FL)
  • 2009 Travel Award, Department of Biological Sciences, Florida International University (Miami, FL)
  • 2009 Biomedical Research Initiative Summer Award, Florida International University (Miami, FL)
  • 2008 Graduate Student Association Travel Award, Florida International University (Miami, FL)
  • 2007 Short Course Certified, Applications Of Unbiased Stereology To Neural Systems, Gainesville, Florida
  • 2007 Biomedical Research Initiative Summer Award, Florida International University (Miami, FL)
  • 2005 Certified, Howard Hughes Medical Institute New Generation Program for Scientific Teaching, Florida International University (Miami, FL)
  • 2005 Graduate Student Association Travel Award, Florida International University (Miami, FL)
  • 2005 Certified, Responsible Conduct of Research Program, Florida International University (Miami, FL)
  • 2004 Biomedical Research Initiative Summer Award, Florida International University (Miami, FL)
  • 2004 Workshop Certified, University Teaching, Florida International University (Miami, FL)

Publications

  • 1. Valdés, J.J., Ramirez, F.M., Juarez, B., Weeks, O.I. (2010). Lithium Enhances Cortical mRNA Expression in Ovariectomized C57BL/6J Mice. Acta Neurobiologiae Experimentalis. 70(3): 288-296.
  • 2. Valdés, J.J., Weeks, O.I. (2010). Combined Estradiol and Lithium Increase ER-a mRNA in Embryonic C57BL/6J Primary Hippocampal Cultures. Acta Neurobiologiae Experimentalis. 70(3): 297-302.
  • 3. Lahiri, D., Rouzaud, F., Namin, S., Keshri, A., Valdés, J.J., Kos, L., Tsoukias, N., Agarwal, A., (2009). Carbon Nanotube Reinforced Polylactide-Caprolactone Copolymer: Mechanical Strengthening and Interaction with Human Osteoblasts in vitro". ACS Applied Materials & Interfaces. 1(11): 2470-2476.
  • 4. Valdés, J.J., Weeks, O.I. (2009). Lithium: A Potential Estrogen Signaling Modulator. Journal of Applied Biomedicine. 7(4): 175-188.
  • 5. Valdés, J.J., Weeks, O.I. (2009). Estradiol and Lithium Chloride Specifically Alter NMDA Receptor Subunit NR1 mRNA and Excitotoxicity in Primary Cultures. Brain Research. 1268:1-12.

Presentations

  • 2008 Estrogen and Lithium Alter NMDAR subunit NR1 mRNA and Cell Viability in Cortical and Hippocampal Brain Cell Cultures. Minority Biomedical Research Support Annual symposium (Florida International University, Miami, FL)
  • 2008 Exposure of cultured murine brain cells to both lithium and estrogen results in altered NR1 and GSK-3 beta mRNA expression. Platform presentation at the American Association of Anatomists (Federation of American Societies for Experimental Biology (FASEB)) annual meeting (San Diego, CA)
  • 2007 Observations of Lithium’s and Estrogen’s Effect on Gene Expression Involved in Learning, Memory and Neuroprotection. Minority Biomedical Research Support Annual symposium (Florida International University, Miami, FL)
  • 2007 An Odyssey to Better Understand Morphological and Molecular Processes Involved in Learning and Memory. Comparative Immunology 8th Annual Symposium (Florida International University, Miami, FL)
  • 2007 From Behavior to Molecules: Preliminary Observation on Lithium’s effect on Learning, Memory and Neuroprotection. Department of Biological Sciences Annual Symposium (Florida International University, Miami, FL)
  • 2004 Lithium: A Memory Enhancer? Comparative Immunology 5th Annual Symposium (Florida International University, Miami, FL)
  • 2004 Lithium and Estrogen: A Synergistic Relationship? Minority Biomedical Research Support Annual symposium (Florida International University, Miami, FL)

Posters

  • 1. Valdés, J.J., Juarez, B., Ramirez, F.M., Ophelia I. Weeks. (2009). Lithium Chloride Enhances Episodic Memory and the Expression of Factors Involved in Learning, Memory and Anti-Apoptosis in Estrogen-Deficient Mice. Gordon Research Conference (Les Diablerets, Switzerland)
  • 2. Valdés, J.J., Weeks, O.I. (2009). Viability of estrogen and lithium-treated primary brain cell cultures following glutamate insult and NR1 mRNA expression of pretreated cultures. Poster Presentation at the American Association of Anatomists (Federation of American Societies for Experimental Biology (FASEB)) annual meeting (New Orleans, LA)
  • 3. Valdés, J.J., Weeks, O.I. (2006). Lithium Chloride Upregulates Bcl-2 Protein Expression in the Frontal Cortex, Hippocampus and Amygdala of C57BL/6J mice. Poster Presentation at the 36th Annual Society for Neuroscience meeting (Atlanta, GA)
  • 4. Valdés, J.J., Volmar, C.-H., Valiente, J., Penaloza, P., Weeks, O.I. (2005). Lithium: A Memory Enhancer. Poster Presentation at the American Association of Anatomists (Federation of American Societies for Experimental Biology (FASEB)) annual meeting (San Diego, CA)

Publications
Total found: 32 records
Cabezas-Cruz A., Alberdi P., Valdés J. J., Villar J.J., de la Fuente J. (2017) Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum. Frontiers in Bioscience-Landmark 22 : 1830-1844.
Cabezas-Cruz A., Alberdi P., Valdés J. J., Villar M., de la Fuente J. (2017) Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis Frontiers in Cellular and Infection Microbiology 7 : 23.
DOI: 10.3389/fcimb.2017.00023
Contreras M., Alberdi P., Mateos-Hernández L., Fernández de Mera I.G., García-Pérez A., Vancová M., Villar M., Ayllón N., Cabezas-Cruz A., Valdés J. J., Stuen S., Gortazar C., de la Fuente J. (2017) Anaplasma phagocytophilum MSP4 and HSP70 Proteins Are Involved in Interactions with Host Cells during Pathogen Infection. Frontiers in Cellular and Infection Microbiology 7 : 307.
DOI: 10.3389/fcimb.2017.00307
Cabezas-Cruz A., Alberdi P., Ayllón N., Valdés J. J., Pierce R., Villar M., de la Fuente J. (2016) Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis Epigenetics 11 : 303-319.
DOI: 10.1080/15592294.2016.1163460
Cabezas-Cruz A., Estrada-Peňa A., Valdés J. J., de la Fuente J. (2016) Be aware of ticks when strolling through the park Frontiers for Young Minds 4 : 24.
DOI: 10.3389/frym.2016.00024
Cabezas-Cruz A., Tonk M., Bouchut A., Pierrot C., Pierce R., Kotsyfakis M., Rahnamaeian M., Vilcinskas A., Khalife J., Valdés J. J. (2016) Antiplasmodial activity is an ancient and conserved feature of tick defensins Frontiers in Microbiology 7 : 1682.
DOI: 10.3389/fmicb.2016.01682
Cabezas-Cruz A., Valdés J. J., de la Fuente J. (2016) Control of vector-borne infectious diseases by human immunity against α-Gal Expert review of vaccines 15 : 953-955.
DOI: 10.1080/14760584.2016.1181547
Tellier G., Lenne A., Cailliau-Maggio K., Cabezas-Cruz A., Valdés J. J., Martoriati A., Aliouat E., Gosset P., Delaire B., Fréville A., Pierrot C., Khalife J. (2016) Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1 Frontiers in Microbiology 7 : 777.
DOI: 10.3389/fmicb.2016.00777
Valdés J. J., Cabezas-Cruz A., Šíma R., Butterill P. T., Růžek D., Nuttall P. (2016) Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection. Scientific Reports 6 : 32372.
DOI: 10.1038/srep32372
Valdés J. J., Gil V., Butterill P. T., Růžek D. (2016) An all-atom, active site exploration of antiviral drugs that target Flaviviridae polymerases. Journal of General Virology 97 : 2552-2565.
DOI: 10.1099/jgv.0.000569
Cabezas-Cruz A., Mateos-Hernández L., Pérez-Cruz M., Valdés J. J., Mera I., Villar M., de la Fuente J. (2015) Regulation of the Immune Response to α-Gal and Vector-borne Diseases Trends in Parasitology 31 : 470-476.
DOI: 10.1016/j.pt.2015.06.016
Cabezas-Cruz A., Valdés J. J., Lancelot J., Pierce R. (2015) Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni BMC Genomics 16 : 980.
DOI: 10.1186/s12864-015-2144-6
Eyer L., Valdés J. J., Gil V., Nencka R., Hřebabecký H., Šála M., Salát J., Černý J., Palus M., De Clercq E., Růžek D. (2015) Nucleoside inhibitors of tick-borne encephalitis virus Antimicrobial Agents and Chemotherapy 59 : 5483-5493.
DOI: 10.1128/AAC.00807-15
Formanová P., Černý J., Bolfíková B., Valdés J. J., Kozlova I., Dzhioev Y., Růžek D. (2015) Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients Ticks and Tick-borne Diseases 6 : 38-46.
DOI: 10.1016/j.ttbdis.2014.09.002
Pinheiro-Silva R., Borges L., Coelho L., Cabezas-Cruz A., Valdés J. J., Do Rosário V., de la Fuente J., Domingos A. (2015) Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection Parasites & Vectors 8 : 485.
DOI: 10.1186/s13071-015-1079-8
Tonk M., Cabezas-Cruz A., Valdés J. J., Grubhoffer L., Rego R. O. M., Estrada-Peňa A., Vilcinskas A., Kotsyfakis M., Rahnamaeian M. (2015) Ixodes ricinus defensins attack distantly-related pathogens Developmental & Comparative Immunology 53 : 358-365.
DOI: 10.1016/j.dci.2015.08.001
Tonk M., Knorr E., Cabezas-Cruz A., Valdés J. J., Kollewe C., Vilcinskas A. (2015) Tribolium castaneum defensins are primarily active against Gram-positive bacteria Journal of Invertebrate Pathology 132 : 208-215.
DOI: 10.1016/j.jip.2015.10.009
Cabezas-Cruz A., Valdés J. J. (2014) Are ticks venomous animals? Frontiers in Zoology 11 : 47.
DOI: 10.1186/1742-9994-11-47
Cabezas-Cruz A., Valdés J. J., de la Fuente J. (2014) Cancer research meets tick vectors for infectious diseases Lancet Infectious Diseases 14 : 916-917.
DOI: 10.1016/S1473-3099(14)70902-8
Cabezas-Cruz A., Valdés J. J., de la Fuente J. (2014) The glycoprotein TRP36 of Ehrlichia sp. UFMG-EV and related cattle pathogen Ehrlichia sp. UFMT-BV evolved from a highly variable clade of E. canis under adaptive diversifying selection Parasites & Vectors 7 : 584.
DOI: 10.1186/s13071-014-0584-5

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CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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