HR Excellence in Science

Mgr. Jan Perner, Ph.D.

Job Position: Head of Laboratory - Laboratory of Molecular Biology of Ticks

Contact details

Phone: +420 38777 5489
E-mail: perner@paru.cas.cz
Room: 337

Curriculum vitae

PERSONAL INFORMATION
Family name, First name: Perner, Jan
Researcher unique identifier(s) (such as ORCID, Research ID, etc. ...): 0000-0001-7719-4251
Date of birth: 20/08/1986
Nationality: Czech
Email: perner@paru.cas.cz
Phone: +420 387775489 / +420 606629139
Room: 337
 
CURRENT POSITIONS
  • 2019 – now Principal Investigator 
    Institute of Parasitology, Biology Centre, Czech Republic
  • 2017 – now Post - doc 
    Institute of Parasitology, Biology Centre, Czech Republic
 
Current grants 
  • Testing of new acaricide for elimination of red poultry mite infestation in farming - Technology Agency of the Czech Republic. Principal Investigator
  • Nutritional factors essential for tick development and reproduction - Czech Science Foundation. Post-doc Team Member
  • Midgut microbial ecology, epithelial immunity, and vector competence of Ixodes ricinus and Amblyomma americanum Czech Science Foundation. Post-doc Team Member
  • Centre for research of pathogenicity and virulence of parasites. European Regional Development Fund and Ministry of Education, Youth and Sport. Post-doc Team Member
 
PUBLICATION LIST
Original Research:
  • Perner J, Kropáčková S, Kopáček P, Ribeiro JMC (2018) Sialome diversity of ticks revealed by RNAseq of single tick salivary glands; PLoS Neglected Tropical Diseases 12:e0006410.
  • Perner J, Kotál J, Hatalová T, Urbanová V, Bartošová-Sojková P, Brophy PM, Kopáček P (2018) Inducible glutathione S-transferase (IrGST1) from the tick Ixodes ricinus is a haem-binding protein; Insect Biochemistry and Molecular Biology 95, 44–54.
  • Hartmann D, Šíma R, Konvičková J, Perner J, Kopáček P, Sojka D (2018) Multiple legumain isoenzymes in ticks; International Journal for Parasitology 48, 167–178.
  • Palus M, Vancová M, Širmarová J, Elsterová J, Perner J, Růžek D (2017) Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity; Virology 507, 110–122.
  • Perner J, Sobotka R, Šíma R, Konvičková J, Sojka D, Oliveira PL, Hajdušek O, Kopáček P (2016) Acquisition of exogenous haem is essential for tick reproduction; eLife 5:e12318.
  • Perner J, Provazník J, Schrenková J, Urbanová V, Ribeiro JMC, Kopáček P (2016) RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks; Scientific Reports 6, 36695.
  • Hajdušek O, Šíma R, Perner J, Loosová G, Harcubová A, Kopáček P (2016) Tick iron and heme metabolism - New target for an anti-tick intervention; Ticks and Tick Borne Diseases 7, 565–572.
  • Sojka D, Pytelková J, Perner J, Horn M, Konvičková J, Schrenková J, Mareš M, Kopáček P (2016) Multienzyme degradation of host serum albumin in ticks; Ticks and Tick Borne Diseases 7, 604–613.
  • Storm J, Perner J, Aparicio I, Patzewitz EM, Olszewski K, Llinas M, Engel PC, Müller S (2011) Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development; Malaria Journal 10:193.

Reviews:
  • Perner J, Gasser RB, Oliveira PL, Kopáček P (2019) Haem Biology in Metazoan Parasites - 'The Bright Side of Haem'; Trends in Parasitology 35, 213–225
  • Hajdušek O, Síma R, Ayllón N, Jalovecká M, Perner J, de la Fuente J, Kopáček P (2013) Interaction of the tick immune system with transmitted pathogens; Frontiers in Cellular and Infection Microbiology 3:26;
  • Commentary:
  • Kopáček P, Perner J (2016) Vector Biology: Tyrosine Degradation Protects Blood Feeders from Death via La Grande Bouffe; Current Biology 26, R763–R765.
 
Book Chapter:
  • Kopáček P, Perner J, Sojka D, Šíma R, Hajdušek O (2018) Molecular Targets to Impair Blood Meal Processing in Ticks. Meng ChQ, Sluder AE, and Selzer PM (Eds). Ectoparasites: Drug Discovery Against Moving Targets; Wiley 139–165.
 
INTELLECTUAL PROPERTY 
  • Utility model (2017-34038): A membrane-based device for breeding and testing adult ticks
  • Utility model (2018-35307): A feeder for breeding and testing ticks in the larval and nymphal stage
 
POPULARISATION OF SCIENCE 
Print media:
2015 –Academic bulletin CAS: Membrane feeding of ticks;

Internet Media:
2016 – Spectrum.de;
2019 – idnes.cz;
2019 – aktualne.cz;
2019 – SME.sk;

Radio:
 

Publications
Total found: 21 records
Perner J., Hajdušek O., Kopáček P. (2022) Independent somatic distribution of heme and iron in ticks Current Opinion in Insect Science 51 : 100916.
DOI: 10.1016/j.cois.2022.100916
Perner J., Kučera M., Frantová H., Urbanová V., Kopáček P., Šíma R. (2022) Lyme disease transmission by severely impaired ticks Open Biology 12 : 210244.
DOI: 10.1098/rsob.210244
Kopáček P., Šíma R., Perner J. (2021) An mRNA-based anti-tick vaccine catches ticks red-handed Science Translational Medicine 13eabm2504 : eabm2504.
DOI: 10.1126/scitranslmed.abm2504
Kozelková T., Doležel D., Grunclová L., Kučera M., Perner J., Kopáček P. (2021) Functional characterization of the insulin signaling pathway in the hard tick Ixodes ricinus Ticks and Tick-borne Diseases 12 : 101694.
DOI: 10.1016/j.ttbdis.2021.101694
Perner J., Hatalová T., Cabello-Donayre M., Urbanová V., Sojka D., Frantová H., Hartmann D., Jirsová D., Pérez-Victoria J.M., Kopáček P. (2021) Haem-responsive gene transporter enables mobilization of host haem in ticks Open Biology 11 : 210048.
DOI: 10.1098/rsob.210048
Garcia Guizzo M., Neupane S., Kučera M., Perner J., Frantová H., da Silva V.T., de Oliveira P.L., Kopáček P., Zurek L. (2020) Poor unstable midgut microbiome of hard ticks contrasts with abundant and stable monospecific microbiome in ovaries Frontiers in Cellular and Infection Microbiology 10 : 211.
DOI: 10.3389/fcimb.2020.00211
Gobl J., Sinha D., Šíma R., Perner J., Kopáček P., Valdés J. J., Rego R. O. M., Cabezas-Cruz A. (2020) Histone Methyltransferase DOT1L Is Involved in Larval Molting and Second Stage Nymphal Feeding in Ornithodoros moubata Vaccines 8 : 157.
DOI: 10.3390/vaccines8020157
Perner J., Helm D., Haberkant P., Hatalová T., Kropáčková S., Ribeiro J., Kopáček P. (2020) The central role of salivary metalloproteases in host acquired resistance to tick feeding Frontiers in Cellular and Infection Microbiology 10 : 563349.
DOI: 10.3389/fcimb.2020.563349
Perner J., Gasser R.B., Oliveira P.L., Kopáček P. (2019) Haem Biology in Metazoan Parasites – ‘The Bright Side of Haem’ Trends in Parasitology 35 : 213–225.
DOI: 10.1016/j.pt.2019.01.001
Hartmann D., Šíma R., Konvičková J., Perner J., Kopáček P., Sojka D. (2018) Multiple legumain isoenzymes in ticks International Journal for Parasitology 48 : 167-178.
DOI: 10.1016/j.ijpara.2017.08.011
Kopáček P., Perner J., Sojka D., Šíma R., Hajdušek O. (2018) Molecular Targets to Impair Blood Meal Processing in Ticks. In: Ch. Q. Meng, A. E. Sluder and P.M Selzer (Eds.), Ectoparasites: Drug Discovery Against Moving Targets Wiley 139–165.
DOI: 10.1002/9783527802883
Perner J., Kotál J., Hatalová T., Urbanová V., Bartošová-Sojková P., Brophy P.M., Kopáček P. (2018) Inducible glutathione S-transferase (IrGST1) from the tick Ixodes ricinus is a haem-binding protein Insect Biochemistry and Molecular Biology DOI: 10.1016/j.ibmb.2018.02.002
Perner J., Kropáčková S., Kopáček P., Ribeiro J. (2018) Sialome diversity of ticks revealed by RNAseq single tick salivary glands PLOS Neglected Tropical Diseases 12 : e0006410.
DOI: 10.1371/journal.pntd.0006410
Palus M., Vancová M., Širmarová J., Elsterová J., Perner J., Růžek D. (2017) Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity. Virology 507 : 110-122.
DOI: 10.1016/j.virol.2017.04.012
Hajdušek O., Šíma R., Perner J., Loosová G., Harcubová A., Kopáček P. (2016) Tick iron and heme metabolism - New target for an anti-tick intervention Ticks and tick-borne diseases 7 : 565-572.
DOI: 10.1016/j.ttbdis.2016.01.006
Kopáček P., Perner J. (2016) Vector Biology: Tyrosine Degradation Protects Blood Feeders from Death via La Grande Bouffe Current Biology 26 : R763-R765.
DOI: 10.1016/j.cub.2016.06.068
Perner J., Provazník J., Schrenková J., Urbanová V., Ribeiro J., Kopáček P. (2016) RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks. Scientific Reports 6 : 36695.
DOI: 10.1038/srep36695
Perner J., Sobotka R., Šíma R., Konvičková J., Sojka D., Lagerblad de Oliveira P., Hajdušek O., Kopáček P. (2016) Acquisition of exogenous haem is essential for tick reproduction eLife 5 : e12318.
DOI: 10.7554/eLife.12318
Sojka D., Pytelková J., Perner J., Horn M., Konvičková J., Schrenková J., Mareš M., Kopáček P. (2016) Multienzyme degradation of host serum albumin in ticks Ticks and Tick-borne Diseases 7 : 603-613.
DOI: 10.1016/j.ttbdis.2015.12.014
Hajdušek O., Šíma R., Ayllón N., Jalovecká M., Perner J., de la Fuente J., Kopáček P. (2013) Interaction of the tick immune system with transmitted pathogens Frontiers in Cellular and Infection Microbiology 3 : 26.
DOI: 10.3389/fcimb.2013.00026

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Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

 

Phone: +420 385 310 351
Fax: +420 387 775 980
E-mail: paru@paru.cas.cz

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