HR Excellence in Science

Mgr. Hana Tykalová

Job Position: PhD student - Laboratory of Molecular Ecology of Vectors and Pathogens

Contact details

Phone: +420 38 777 6220
E-mail: htykalova@prf.jcu.cz
Room: C01 008

Curriculum vitae

Date and place of birth: January 22, 1985, Chomutov, Česká republika.

Education:

  • 2004-2007 – BSc. thesis: The influence of salivary gland extracts (SGE) and saliva of the tick Ixodes ricinus on the replication of tick-borne encephalitis virus under in vitro conditions. Supervisor: Doc. RNDr. Jan Kopecký, CSc. Faculty of Biology, University of South Bohemia.
  • 2007-2009 – MSc thesis: Changes in global gene expression in human neural cells following tick-borne encephalitis virus infection. Supervisor: RNDr. Daniel Růžek, PhD. Faculty of Biology, University of South Bohemia.
  • 2009-now– PhD. thesis: Imunologické aspekty infekce neurálních buněk virem klíšťové encefalitidy. Supervisor: Prof. RNDr. Libor Grubhoffer, CSc. Faculty of Science, University of South Bohemia.

Employment:

  • 2008-now – Institute of Parasitology, Biological Centre of the AS CR, České Budějovice.

Practical skills:

  • 2009 - Communication skills in science - The regional unit South Bohemia (the process of communication, the basic rules of presenatation of the scientific work, the rhetoric)
  • 2009 - Workshop “The use of microarrays in biomedicine” - KRD (microchips).

The most important publications:

  • Růžek D., Šťastná H., Kopecký J., Grubhoffer L.: Multiplex RT-PCR for detection and subtyping of tick-borne encephalitis virus. J. Clin. Virol. 36 (Suppl. 2):S32. 2006.
  • Růžek D., Šťastná H., Kopecký J., Golovjova I., Grubhoffer L.: Rapid subtyping of tick-borne encephalitis virus-isolates using multiplex RT-PCR. J. Virol. Meth. 144:133-137. 2007.
  • Ahantarig A., Růžek D., Vancová M., Janowitz A., Šťastná H., Tesařová M., Grubhoffer L.: Tick-borne encephalitis virus infection of cultured mouse macrophages. Intervirology 52:283-290.2009

Presentations:

  • 2010: “Changes in global gene expression in human neural cells following tick-borne encephalitis virus infection (Šťastná H., Růžek D., Grubhoffer L.); EMBO Workshop - Viruses and Innate Immunity, Dublin, Ireland.
  • 2009: “Molecular interaction of tick-borne encephalitis virus with cells of neural origin” (Šťastná H., Růžek D., Kopecký J., Grubhoffer L.); Labudove dni, Bratislava, Slovak Rebublic.
  • 2008: “Molecular interaction of tick-borne encephalitis virus with cells of neural origin” (Šťastná H., Růžek D., Kopecký J., Grubhoffer L.); XIV. Ingternational Congress of Virology. Istanbul, Turkey.
  • 2008: “The neuropathogenesis of tick-borne encephalitis” (Růžek D., Vancová M., Šťastná H., Štěrba J., Kopecký J., Grubhoffer L.); XIV. Ingternational Congress of Virology. Istanbul, Turkey.
  • 2007: “The influnce of tick saliva on the replication of tick-borne encephalitis virus” (Šťastná H., Růžek D., Grubhoffer L., Kopecký J.); Third European Congress of Virology, Nurnberg, Germany.
  • 2007: “Vliv klíštěcích slin na replikaci viru klíšťové encefalitidy v podmínkách in vitro” (Šťastná H., R§žek D., Grubhoffer L., Kopecký J.); 24. kongres Ěskoslovenské společnosti mirkobiologické. Liberec, Czech Republic.

Publications
Total found: 7 records
Selinger M., Věchtová P., Tykalová H., Ošlejšková P., Rumlová M., Štěrba J., Grubhoffer L. (2022) Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors Computational and Structural Biotechnology Journal 20 : 2759-2777.
DOI: 10.1016/j.csbj.2022.05.052
Helmová R., Hönig V., Tykalová H., Palus M., Bell-Sakyi L., Grubhoffer L. (2020) Tick-borne encephalitis virus adaptation in different host environments and existence of quasispecies Viruses 12 : 902.
DOI: 10.3390/v12080902
Selinger M., Tykalová H., Štěrba J., Věchtová P., Vavrušková Z., Lieskovská J., Kohl A., Schnettler E., Grubhoffer L. (2019) Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin. Plos Neglected Tropical Diseases 27 : e0007745.
DOI: 10.1371/journal.pntd.0007745
Černý J., Selinger M., Palus M., Vavrušková Z., Tykalová H., Bell-Sakyi L., Štěrba J., Grubhoffer L., Růžek D. (2016) Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells Virus Genes 52 : 309-316.
DOI: 10.1007/s11262-015-1273-y
Hönig V., Švec P., Halas P., Vavrušková Z., Šťastná H., Kilian P., Vrtišková V., Dorňáková V., Dupejová J., Simonová Z., Mondeková H., Erhart J., Štěrba J., Golovchenko M., Grubhoffer L., Rudenko N. (2015) Ticks and tick-borne pathogens in South Bohemia (Czech Republic) - spatial variability in Ixodes ricinus abundance, Borrelia burgdorferi and tick-borne encephalitis virus prevalence Ticks and Tick-borne diseases 6 : 559-567.
DOI: 10.1016/j.ttbdis.2015.04.010
Weisheit S., Villar M., Tykalová H., Popara M., Loecherbach J., Watson M., Růžek D., Grubhoffer L., de la , Fazakerley J., Bell-Sakyi L. (2015) Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis Parasites & Vectors 8 : 599.
DOI: 10.1186/s13071-015-1210-x
Schnettler E., Šťastná H., Watson M., Sharma M., Sterken M., Obbard D., Lewis S., Mcfarlane M., Bell-Sakyi L., Barry G., Weisheit S., Best S., Kuhn R., Pijlman G., Chase-Topping M., Gould E., Grubhoffer L., Fazakerley J., Kohl A. (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses Nucleic Acids Research 42 : 14.
DOI: 10.1093/nar/gku657

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

 

Phone: +420 385 310 351
Fax: +420 387 775 980
E-mail: paru@paru.cas.cz

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