RNDr. Ondřej Hajdušek, Ph.D.

Job Position: Research Scientist - Laboratory of Molecular Biology of Ticks

Contact details

Phone: +420 387775496
E-mail: hajdus@paru.cas.cz
Room: 337

Description

Research interests

  • Vaccines against ticks and tick-transmitted diseases
  • Tick innate immunity

Key words: tick, Ixodes, Borrelia, Babesia, Anaplasma, iron, ferritin, innate immunity

Curriculum vitae

Education:    

  • Bachelor program - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic (Biology; Biomedicine laboratory technique)
  • Masters program  - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic (Parasitology)
  • Ph.D. program (graduated 2009) - University of South Bohemia in České Budějovice, Faculty of Science, Czech Republic (Parasitology)
  • Postdoctoral research - Institut de Biologie Moléculaire et Cellulaire (IBMC), CNRS UPR 9022 (Réponse immunitaire et développement chez les Insectes), Strasbourg, France (3 years)

Science visits:

  • 1998 -    PHLS London (UK) - science visit  (1 week)
  • 2001 -    University of Glasgow (UK) - Socrates Erasmus program (4 months)
  • 2005 -    National Research Council of Canada, Ottawa (CAN) - science visit (3 months)
  • 2006 -    Centre National de la Recherche Scientifique, Strasbourg (FRA) - science visit (2 months)

Awards:

  • 2009 -    Dean´s award - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic
  • 2009 -    Rector´s award - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic
  • 2009 -    Scopus Young Researcher Award, Czech Republic

Grants:

  • 2010-2012 -   EMBO Long Term Fellowship
  • 2013-2015 -   Grant agency of the Czech republic (GACR) - 13-27630P
  • 2013-2015 -   MODBIOLIN, 7FP, GA No. 316304
  • 2014-2018 -    ANTIDotE, 7FP EU
  • 2016-2019 -   Grant agency of the Czech republic (GACR) - 17-27386S

Publications
Total found: 47 records
Matoušková Z., Orsághová K., Srb P., Pytelková J., Kukačka Z., Buša M., Hajdušek O., Šíma R., Fábry M., Novák P., Horn M., Kopáček P., Mareš M. (2024) An unusual two-domain thyropin from tick saliva: NMR solution structure and highly selective inhibition of cysteine cathepsins modulated by glycosaminoglycans International Journal of Molecular Sciences 25 : 2240.
DOI: 10.3390/ijms25042240
Urbanová V., Lu S., Kalinová E., Martins L., Kozelková T., Dycka F., Ribeiro J., Hajdušek O., Perner J., Kopáček P. (2024) From the fat body to the hemolymph: Profiling tick immune and storage proteins through transcriptomics and proteomics Insect Biochemistry and Molecular Biology 5 : 104072.
DOI: 10.1016/j.ibmb.2024.104072
Guerrib F., Ning C., Mateos-Hernández L., Rakotobe S., Park Y., Hajdušek O., Perner J., Vancová M., Valdés J. J., Šimo L. (2023) Dual SIFamide receptors in Ixodes salivary glands Insect Biochemistry and Molecular Biology 158 : 103963.
DOI: 10.1016/j.ibmb.2023.103963
Hajdušek O., Kopáček P., Perner J. (2023) Experimental platforms for functional genomics in ticks Current Opinion in Insect Science 59 : 101102.
DOI: 10.1016/j.cois.2023.101102
Hajdušek O., Perner J. (2023) VLA15, a new global Lyme disease vaccine undergoes clinical trials Lancet Infectious Diseases 23 : 1105–1106.
DOI: 10.1016/S1473-3099(23)00312-2
Klouwens M.J., Trentelman J.J.A., Barriales D., Ersoz J.I., Azkargorta M., Elortza F., Šíma R., Hajdušek O., Lavin J.L., Tomás-Cortázar J., Escobes Corcuera I., Colstrup E., Nayak A., Ruíz M.I., Rodriguez H., Nijhof A., Anguita J., Hovius J.W.R. (2023) The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine Vaccine 41 : 1951–1960.
DOI: 10.1016/j.vaccine.2023.02.003
Ribeiro J., Hartmann D., Bartošová-Sojková P., Debat H., Moos M., Fara J., Šimek P., Palus M., Kučera M., Hajdušek O., Sojka D., Kopáček P., Perner J. (2023) Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq Communications Biology 6 : 517.
DOI: 10.1038/s42003-023-04907-x
Perner J., Hajdušek O., Kopáček P. (2022) Independent somatic distribution of heme and iron in ticks Current Opinion in Insect Science 51 : 100916.
DOI: 10.1016/j.cois.2022.100916
Trentelman J.J.A., de Vogel F.A., Colstrup E., Šíma R., Coumou J., Koetsveld J., Klouwens M.J., Nayak A., Ersoz J., Barriales D., Tomás-Cortázar J., Narasimhan S., Hajdušek O., Anguita J., Hovius J. (2022) Identification of novel conserved Ixodes vaccine candidates; a promising role for non-secreted salivary gland proteins Vaccine 40 : 7593–7603.
DOI: 10.1016/j.vaccine.2022.10.032
Klouwens M.J., Trentelman J.J., Ersoz J.I., Nieves Marques Porto F., Šíma R., Hajdušek O., Thakur M., Hovius J. (2021) Investigating BB0405 as a novel Borrelia afzelii vaccination candidate in Lyme borreliosis Scientific Reports 11 : 4775.
DOI: 10.1038/s41598-021-84130-y
Kotál J., Polderdijk S.G.I., Langhansová H., Ederová M., Martins L., Beránková Z., Chlastáková A., Hajdušek O., Kotsyfakis M., Huntington J.A., Chmelař J. (2021) Ixodes ricinus salivary serpin iripin-8 inhibits the intrinsic pathway of coagulation and complement International Journal of Molecular Sciences 22 : 9480.
DOI: 10.3390/ijms22179480
Mahmood S., Šíma R., Urbanová V., Trentelman J.J., Krezdorn N., Winter P., Kopáček P., Hovius J., Hajdušek O. (2021) Identification of Tick Ixodes ricinus Midgut Genes Differentially Expressed During the Transmission of Borrelia afzelii Spirochetes Using a Transcriptomic Approach Frontiers in Immunology 11 : 612412.
DOI: 10.3389/fimmu.2020.612412
Trentelman J., Tomás-Cortázar J., Knorr S. , Barriales D., Hajdušek O., Šíma R., Ersoz J.I., Narasimhan S., Fikrig E., Nijhof A., Anguita J., Hovius J. (2021) Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine Scientific Reports 11 : 15745.
DOI: 10.1038/s41598-021-92538-9
Kamp H.D., Swanson K.A., Wei R.R., Dhal P.K., Dharanipragada R., Kern A., Sharma B., Šíma R., Hajdušek O., Hu L.T., Wei Ch.-J., Nabel G.J. (2020) Design of a broadly reactive Lyme disease vaccine npj Vaccines 5 : 33.
DOI: 10.1038/s41541-020-0183-8
Mateos-Hernández L., Defaye B., Vancová M., Hajdušek O., Šíma R., Park Y., Attoui H., Šimo L. (2020) Cholinergic axons regulate type I acini in salivary glands of Ixodes ricinus and Ixodes scapularis ticks Scientific Reports 10 : 16054.
DOI: 10.1038/s41598-020-73077-1
Trentelman J.J., Šíma R., Krezdorn N., Tomás-Cortázar J., Barriales D., Takumi K., Butler J.M., Sprong H., Klouwens M.J., Urbanová V., Mahmood S., Winter P., Kopáček P., Anguita J., Hajdušek O., Hovius J. (2020) A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission Scientific Reports 10 : 20061.
DOI: 10.1038/s41598-020-76268-y
Pospíšilová Pospíšilová, Urbanová V., Hes O., Kopáček P., Hajdušek O., Šíma R. (2019) Tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs to mice Infection and Immunity 87 : e00896-18.
DOI: 10.1128/IAI.00896-18
Rego R. O. M., Trentelman J.J., Anguita J., Nijhof A., Sprong H., Klempa B., Hajdušek O., Tomás-Corázar J., Azagi T., Strnad M., Knorr S. , Šíma R., Jalovecká M., Havlíková S., Ličková M., Sláviková M., Kopáček P., Grubhoffer L., Hovius J. (2019) Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission Parasites & Vectors 12 : 229.
DOI: 10.1186/s13071-019-3468-x
Jalovecká M., Hajdušek O., Sojka D., Kopáček P., Malandrin L. (2018) The Complexity of Piroplasms Life Cycles Frontiers in Cellular and Infection Microbiology 8 : 248.
DOI: 10.3389/fcimb.2018.00248
Jalovecká M., Hartmann D., Miyamoto Y., Eckmann L. , Hajdušek O., O´Donoghue A.J. , Sojka D. (2018) Validation of Babesia proteasome as a drug target International Journal for Parasitology-Drugs and Drug Resistance 8 : 394–402.
DOI: 10.1016/j.ijpddr.2018.08.001

More publications

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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