Laboratory of Molecular Ecology of Vectors and Pathogens (Ryan O.M. Rego)

Mission Statement: Vector-borne diseases particularly those caused by tick-transmitted pathogens including spirochetes are damaging for animal and human health. The laboratory is primarily focused on two research prerogatives, an understanding of the biological drivers associated with vector competence of the tick and pathogen variation at the species and strain level. Our goal is at adapting and harnessing molecular, biochemical and bioinformatic tools that will help us understand such differences in aspects associated with tick physiology, pathogen phenotypes and host susceptibility.  We want to collaborate with important stakeholders in the public/private sector and to utilize our data for diagnostics, treatment or prediction of the future spread of ticks/diseases.

Selected publications:
Strnad M., Koizumi N., Nakamura S., Vancová M., Rego R. O. M. (2024) It’s not all about flagella – sticky invasion by pathogenic spirochetes Trends in Parasitology 40: 378-385.
DOI: 10.1016/j.pt.2024.03.004
Strnad M., Rudenko N., Rego R. O. M. (2023) Pathogenicity and Virulence of Borrelia burgdorferi Virulence 14: 2265015.
DOI: 10.1080/21505594.2023.2265015
Golovchenko M., Opelka J., Vancová M., Sehadová H., Králíková V., Dobias M., Raska M., Krupka M., Sloupenská K., Rudenko N. (2023) Concurrent infection of the human brain with multiple species of Lyme disease spirochetes International Journal of Molecular Sciences 24: 16906.
DOI: 10.3390/ijms242316906
Rudenko N., Golovchenko M., Horák A., Grubhoffer L., Mongodin E.F., Fraser C.M., Qiu W., Luft B., Morgan R.G., Casjens S.R., Schutzer S. (2023) Genomic confirmation of Borrelia garinii in the USA Emerging Infectious Diseases 29: 1.
DOI: 10.3201/eid2901.220930
Strnad M., Oh Y.J., Vancová M., Hain L., Salo J., Grubhoffer L., Nebesářová J., Hytönen J., Hinterdorfer P., Rego R. O. M. (2021) Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix Communications Biology 4: 268 .
DOI: 10.1038/s42003-021-01783-1

All publications (206)

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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